Atypicalities in Cortical Structure, Handedness, and Functional Lateralization for Language in Autism Spectrum Disorders

Lindell, Annukka K.; Hudry, Kristelle

doi:10.1007/s11065-013-9234-5

Cited by 167 publications

(126 citation statements)

References 99 publications

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“…Research from the human literature suggests that people with pervasive developmental disorders (e.g., Autism Spectrum Disorder), veer more towards left-than right-handedness (for review, Lindell & Hudry, 2013). There is a tendency for such individuals to be relatively 'rigid' in their outlook, finding it challenging to overlook minute details.…”

Section: Discussionmentioning

confidence: 99%

Cognitive bias and paw preference in the domestic dog (Canis familiaris).

Wells¹,

Hepper²,

Milligan³

et al. 2017

Journal of Comparative Psychology

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Limb use, an indicator of hemispheric functioning, may be a useful predictor of cognitive bias and hence vulnerability to welfare risk. The relationship between cognitive bias and motor asymmetry, however, has been subject to little investigation. This study explored the association between motor asymmetry and cognitive bias in the domestic dog, a species that displays lateral bias in the form of paw preferences and exhibits positive and negative affective states. Thirty pet dogs had their paw preferences assessed using the Kong ball test. The subjects' affective state was assessed using a cognitive bias test in which the animals' latency to approach a bowl placed in 1 of 3 ambiguous positions was recorded. Animals veering more toward a left-paw preference were found to be significantly slower to approach the bowl placed in 1 of the ambiguous positions than ambilateral or right-pawed dogs. Left-pawed subjects approached the bowl located at the 3 ambiguous positions at roughly the same speed, while ambilateral and right-pawed animals became increasingly slower to approach the bowl the further it was located from the baited food bowl. The study points to a possible relationship between cognitive bias and paw preference in the dog, with left-pawed animals being more negative or "pessimistic" in their cognitive outlook than right-pawed or ambilateral individuals. It is proposed that limb preference testing might offer a more practical and straightforward way of identifying individuals at risk from poor welfare by virtue of how they perceive the world than more time-consuming cognitive bias tests.

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Section: Discussionmentioning

confidence: 99%

Cognitive bias and paw preference in the domestic dog (Canis familiaris).

Wells¹,

Hepper²,

Milligan³

et al. 2017

Journal of Comparative Psychology

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“…While mixed-handedness makes up approximately 3-4% of the general population [e.g. 42], populations with ASD reveal mixed-handedness at proportions of between 17% and 47% [for a review see 43]. However, it has been reported that children with ASD who possess either left or right hand dominance, generally tend to have stronger language capabilities, compared with mixed-handed children with ASD.…”

Section: Introductionmentioning

confidence: 99%

Handedness as a marker of cerebral lateralization in children with and without autism

Forrester

Pegler

Thomas

et al. 2014

Behavioural Brain Research

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h i g h l i g h t s• We report on a detailed set of hand actions from two populations of right-handed boys.• Typically developing boys demonstrated a right hand bias for actions to objects.• Typically developing boys also demonstrated a left hand bias for actions to the self.• Boys with autism revealed mixed-handedness for actions to objects and to the self.• Handedness reveals a dissociation for functional specialization of the hemispheres. a r t i c l e i n f o b s t r a c tWe employed a multiple case studies approach to investigate lateralization of hand actions in typically and atypically developing children between 4 and 5 years of age. We report on a detailed set of over 1200 hand actions made by four typically developing boys and four boys with autism. Participants were assessed for unimanual hand actions to both objects and the self (self-directed behaviors). Individual and group analyses suggest that typically developing children have a right hand dominance for hand actions to objects and a left hand dominance for hand actions for self-directed behaviors, revealing a possible dissociation for functional specialization of the left and right hemispheres respectively. Children with autism demonstrated mixed-handedness for both target conditions, consistent with the hypothesis that there is reduced cerebral specialization in these children. The findings are consistent with the view that observed lateralized motor action can serve as an indirect behavioral marker for evidence of cerebral lateralization.

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“…The most documented risk is for autism 24 . With relevance to the present study, theories have linked the communication difficulties in autism with atypical lateralisation 25 and left hemisphere dysfunction 26 . In addition, the 47,XXX and 47,XXY karyotypes have been explored as genetic models for schizophrenia 5 , although an increased risk for schizophrenia is not well established 27 .…”

Section: Cc-by-nc-ndmentioning

confidence: 84%

Sex chromosome trisomies are not associated with atypical lateralisation for language

Wilson

Bishop

2018

Preprint

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AimIndividuals with a sex chromosome trisomy (SCT) have disproportionate problems with language compared to nonverbal skills. This may result from disruption to the typical left hemisphere bias for language processing. We tested the hypothesis that SCTs would be associated with reduced left lateralisation for language.MethodIn a cross-sectional design, language laterality was measured during an animation description task using functional transcranial Doppler ultrasonography (fTCD). Data were available for 75 children with an SCT (26 47,XXX girls, 25 47,XXY boys, and 24 47,XYY boys; mean age was 11;4 years, SD = 3;10 years), and 132 comparison children with typical karyotypes (69 boys; mean age was 9;1 years, SD = 1;7 years).ResultsLateralisation for language did not differ between the SCT and comparison groups, either in mean laterality index or relative frequency of each laterality category (left, bilateral and right). There were no differences when splitting the SCT group by trisomy. Handedness also showed no group effects.InterpretationOur data provide no evidence for disrupted lateralisation for language in SCTs. The brain basis of the cognitive phenotype in SCTs is unlikely to be a failure of the left hemisphere to specialise for language, as previously suggested.What this paper addsChildren with a sex chromosome trisomy (SCT) have typically lateralised language.This disconfirms theories linking language problems to hemispheric specialization in SCTs

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Atypicalities in Cortical Structure, Handedness, and Functional Lateralization for Language in Autism Spectrum Disorders

Cited by 167 publications

References 99 publications

Cognitive bias and paw preference in the domestic dog (Canis familiaris).

Cognitive bias and paw preference in the domestic dog (Canis familiaris).

Handedness as a marker of cerebral lateralization in children with and without autism

Sex chromosome trisomies are not associated with atypical lateralisation for language

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