Atypical β2-Microglobulin Amyloidosis Following Short-Term Hemodialysis

Albers, Sharon E.; Fenske, N; Glass, L. Frank; Brozena, S J; Szakacs, Jeno E.

doi:10.1097/00000372-199404000-00014

Cited by 23 publications

(7 citation statements)

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“…However, patients with AGel amyloidosis can show hernias 2 and lax obstructing pharyngeal soft tissues, 31 suggesting that noncutaneous tissues may be affected by elastolysis. Apart from cutis laxa, the present patients had various other cutaneous manifestations, which are summarized and compared with other amyloidoses in Table 3 16,18 , 24–28 . Our patients showed slowly healing fissures, possibly related to AGel neuropathy, 33 in line with transthyretin amyloid neuropathy 27 .…”

Section: Discussionsupporting

confidence: 56%

“…Cutaneous manifestations have been considered rare in systemic amyloidoses with the exception of primary and myeloma‐associated amyloidosis (AL amyloidosis) 18 . However, skin involvement was recently found to be principal in apolipoprotein A1 amyloidosis, 24 and it may also occur in systemic amyloid A (AA), 25 β 2 ‐microglobulin 26 and transthyretin amyloidoses 27 . Cutaneous cystatin C amyloid deposits in hereditary cerebral haemorrhage with amyloidosis are asymptomatic 28 .…”

Section: Discussionmentioning

confidence: 99%

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Cutis laxa in hereditary gelsolin amyloidosis

Kiuru-Enari¹,

Keski‐Oja

Haltia³

2005

Br J Dermatol

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Widespread skin involvement with AGel deposition and elastic fibre involvement are essential pathological features in AGel amyloidosis, and contribute to the characteristic cutis laxa, dramatic in old age. Codistribution of AGel and AP, with demonstrated specific binding affinity for amyloid fibrils, suggests that elastic fibre-associated AP acts as a matrix for cutaneous amyloid deposition in AGel amyloidosis.

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Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Cutis laxa in hereditary gelsolin amyloidosis

Kiuru-Enari¹,

Keski‐Oja

Haltia³

2005

Br J Dermatol

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“…130,131 It has mainly been reported in long-term hemodialysis patients, 130,132 but cases after short-term dialysis have also been described. 133 Although this type of amyloidosis uncommonly involves the skin, some cases have been reported with lichenoid plaque type of skin eruptions, 130 papules on arms and trunk, 132 or flaccid plaques. 134 It can also appear as subcutaneous nodules, mainly on the buttocks.…”

Section: Changes In the Skin In Systemic Amyloidosismentioning

confidence: 99%

Cutaneous Amyloidosis: A Concept Review

Fernández-Flores

2012

The American Journal of Dermatopathology

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Concepts and semantics are crucial for good communication between clinicians and pathologists. Amyloidosis was described more than 150 years ago. Therefore, the terminology related to it is abundant, varied, and sometimes complex. In this report, we intend to discuss several terms related to the disease, with special emphasis on cutaneous amyloidosis. We present a review, from Virchow to present, of the concepts related to amyloidosis: its nature, the classification of cutaneous forms of the disease, and the techniques used in its diagnosis.

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“…The hair follicle, for example, is both target for and source of immunomodulatory stress mediators, similar to the hypothalamus–pituitary–adrenal axis (66,68,74). It is also well known that certain proteins are altered by inflammation, thus leading to the formation of amyloid deposits (75–79) in brain, skin and other organs (38,80). In skin, this type of amyloid is most often referred to as AA‐amyloid, because serum amyloid A (SAA) acts as the precursor protein (11).…”

Section: Brain–skin Axismentioning

confidence: 99%

Amyloid in skin and brain: What′s the link?

Schreml

Kaiser

Landthaler

et al. 2010

Experimental Dermatology

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For too long, amyloids have been under general suspicion to merely cause diseases. In recent years, we have learned that these interesting proteins may also fulfill important biological tasks. Moreover, recent publications show emerging evidence for a so-called brain-skin axis. This viewpoint paper aims to address the question what is known about the link between brain and skin based on the literature available for two diseases caused by amyloid formation: Alzheimer¢s disease (AD) and cutaneous amyloidoses. In addition, we acquaint the reader with a different perspective on the role of amyloid in skin and brain.

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Atypical β2-Microglobulin Amyloidosis Following Short-Term Hemodialysis

Cited by 23 publications

References 0 publications

Cutis laxa in hereditary gelsolin amyloidosis

Cutis laxa in hereditary gelsolin amyloidosis

Cutaneous Amyloidosis: A Concept Review

Amyloid in skin and brain: What′s the link?

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