Atypical spindle cell/pleomorphic lipomatous tumor of the stomach: A case report

When is a lipoma not a lipoma? Case report presenting a lipoblastoma-like tumor of the gluteal cleft in an older gentleman with literature review

“…Given the findings on imaging, the differential is broad but from a clinical, pathologic, and molecular standpoint, LLTs have similarities to low-grade myxofibrosarcoma (similar morphological appearance, but intact Rb expression and lack of SMA expression argues against this) [15] , cellular angiofibroma (similar morphological appearance, both desmin − CD34 + , but intact Rb and S100 expression argues against this) [14] , [16] , atypical spindle cell lipomatous tumor (both are negative for MDM2 amplification, CD34 + S100 + , but Rb is typically lost in this tumor) [7] , myxoid liposarcoma (both negative for MDM2 amplification and S100 + , although the absence of DDIT3 translocation argues against this) [3] , [9] , [17] , and spindle cell tumors (both SOX10 − CD34 + S100 + , but lacking NTRK expression/gene fusion commonly found in spindle cell tumors makes it unlikely) [18] .…”

“…There is even less of a consensus on CD34 and S100 expression in LLTs. LLTs have been reported to be CD34 + S100 + [5] , S100 − and occasionally CD34 + [4] , and CD34 − , without reporting S100 expression [1] , [4] , [5] , [6] , making them share similarities with atypical spindle cell lipomatous tumors, atypical pleomorphic lipomatous tumors, and spindle cell tumors, which are all variably CD34 + S100 + [3] , [7] , or myxoid liposarcomas, which are CD34 − and variably S100 + [8] , [9] . The difficulty with these molecular discrepancies is that it does not allow diagnostic differentiation between LLTs and other lipomatous tumors such as atypical spindle cell lipomatous tumors, atypical pleomorphic lipomatous tumors, and spindle cell tumors and thus clinicians should be familiar with this entity.…”

Esophageal spindle cell lipoma

“…Dedifferentiation or metastases has not been reported. No case of ASCLT has been described in the esophagus; however, a case has recently been documented in gastric cardia [ 25 ].…”

A case report on atypical spindle cell lipomatous tumor: A rare entity

“…Myofibroblastoma of soft tissue is a benign neoplasm, occurring most often in the inguinal/groin areas [ 8 ] and Cellular angiofibroma is a benign, fibroblastic and vascular-rich neoplasm, arising in the superficial soft tissues of the vulvovaginal and the inguinoscrotal or para-testicular areas [ 9 ]. However, both these two entities can be differentiated from ASPLT as both show less-prominent fat component and CAF showing prominent hyalinized vessels [ 5 ].…”