Atypical Presentation and Dermoscopic Evaluation of Cutaneous Rosai-Dorfman Disease

Rodríguez-Blanco, Isabel; Suárez‐Peñaranda, José Manuel; Toribio, Jaime

doi:10.2340/00015555-0629

Cited by 11 publications

(6 citation statements)

References 14 publications

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“…The efficacy of treatment is not clear. Various treatment modalities exist, including steroid therapy, chemotherapeutic regimens, radiotherapy, surgery, and combinations of the above (3,5). The choice of glucocorticoid treatment in the current case showed good results in long-term follow-up.…”

Section: Discussionmentioning

confidence: 56%

“…Histiocytes, occasionally undergoing mitosis, appeared large and foamy, containing abundant cytoplasm, either granular or vacuolated, with vesicular nuclei round-to-oval in shape. Significantly, large histiocytes with emperipolesis and positive staining for S-100 and CD68, but negative staining for CD1a, were observed (5,6). Clinically, the typical symptoms of RDD are painless enlargement of bilateral cervical lymph nodes with fever, elevated neutrophils, increased ESR, and hyperglobulinaemia (7).…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Rosai-Dorfman Disease with Systemic Multiple Involvement: A Case Report

Tang²,

Shi³

et al. 2019

Acta Derm Venereol

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Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 98%

Rosai-Dorfman Disease with Systemic Multiple Involvement: A Case Report

Tang²,

Shi³

et al. 2019

Acta Derm Venereol

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“…The phenomenon of emperipolesis, which represents the presence of intact lymphocytes within histiocytes, is frequently observed. Rosai-Dorfman disease stains positively for S100 protein and CD68, but negatively for CD1a [4]. The treatment of this entity is difficult, surgical excision of the lesions has been helpful in certain cases, which is the case for our patient.…”

Section: What Is Your Diagnosis?mentioning

confidence: 51%

Firm Yellowish Nodule on the Face of a 7-year-Old Child: What is Your Diagnosis?

Dahhouki¹,

Mounia²,

Douhi³

et al. 2020

JDR

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“…[ 12 ] On dermoscopy, lesions classically resemble ovoid structures on an erythematous base with multiple yellowish structures in the periphery. [ 13 14 ]…”

Section: Discussionmentioning

confidence: 99%

Purely cutaneous rosai-dorfman disease with immunohistochemistry

et al. 2013

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Background:The cutaneous form of Rosai-Dorfman disease (RDD) is a rare entity that manifests solely with skin papules or nodules and does not present with the usual myriad of symptoms of classical RDD.Aims:To analyze the most recent publications regarding cutaneous RDD to point out updated, relevant aspects regarding future directions for clinical recognition and management. To identify histopathologic and immunohistochemical findings in skin lesions that permit diagnosis.Materials and Methods:We present a case of a gentleman with a history of multiple lipomas with a new solitary nodule on physical exam; microscopic examination shows the typical findings of RDD with the associated diagnostic immunohistochemical profile, as well as the expected finding of histiocytes engulfing other intact inflammatory cells.Results:Our patient was managed with surgical excision of the entire lesion, one of the several available treatment options. Long-term follow-up 2 years later did not reveal any complications, recurrences, or new lesions.Conclusion:The diagnosis of cutaneous RDD is differentiated from other histiocytic conditions by the combination of clinical findings accompanied by histopathologic and immunohistochemical confirmation.

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Atypical Presentation and Dermoscopic Evaluation of Cutaneous Rosai-Dorfman Disease

Cited by 11 publications

References 14 publications

Rosai-Dorfman Disease with Systemic Multiple Involvement: A Case Report

Rosai-Dorfman Disease with Systemic Multiple Involvement: A Case Report

Firm Yellowish Nodule on the Face of a 7-year-Old Child: What is Your Diagnosis?

Purely cutaneous rosai-dorfman disease with immunohistochemistry

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