Purely cutaneous rosai-dorfman disease with immunohistochemistry

Farooq, Uzma; Chacon, Anna; Vincek, Vladimir; Elgart, George W.

doi:10.4103/0019-5154.119953

Cited by 13 publications

(7 citation statements)

References 21 publications

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“…Treatment options for localized cutaneous LCH and RDD include surgical excision, cryotherapy, intralesional corticosteroid injection, radiotherapy, dapsone, acitretin, pulsed-dye laser, and close clinical monitoring. 8 , 12 , 20 …”

Section: Discussionmentioning

confidence: 99%

Combined Cutaneous Rosai-Dorfman Disease and Localized Cutaneous Langerhans Cell Histiocytosis Within a Single Subcutaneous Nodule

Litzner

Subtil

Vidal

2015

The American Journal of Dermatopathology

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Rosai-Dorfman disease (RDD) is a reactive multisystem histiocytosis that typically presents with cervical lymphadenopathy and systemic symptoms. Cutaneous involvement occurs in approximately 10% of cases, and 3% of cases are limited to the skin without nodal or other extranodal involvement. Langerhans cell histiocytosis (LCH) is a clonal histiocytosis with a wide spectrum of presentations ranging from isolated skin or bone disease to multisystem involvement. Rare case reports have identified concomitant presentation of RDD and LCH; however, most of these reports have involved LCH and RDD occurring concurrently but at separate sites. We present a rare case of concurrent RDD and LCH presenting within a single skin nodule. The patient did not have any evidence of systemic involvement and has remained stable without additional treatment. We also review the literature on this unusual co-presentation and suggest possible underlying mechanisms. Finally, we recommend baseline laboratory and imaging studies and discuss treatment options based on the available evidence.

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Section: Discussionmentioning

confidence: 99%

Combined Cutaneous Rosai-Dorfman Disease and Localized Cutaneous Langerhans Cell Histiocytosis Within a Single Subcutaneous Nodule

Litzner

Subtil

Vidal

2015

The American Journal of Dermatopathology

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“…1 One study reported a predilection for the extremities. 2 Although very rare in children, CRDD including multifocal forms 3 has been described in pediatric patients. 4,5 Histopathology revealing histiocytic infiltration with emperipolesis is a useful non-pathognomonic clue for the diagnosis of RDD.…”

Section: Diagnosis: Cutaneous Rosai-dorfman Diseasementioning

confidence: 99%

“…Lorena Alexandra Mija MD 1 Nelson Piche MD 2 Viktor Kokta MD 3 Josee Dubois MD 4 Jerome Coulombe MD 5 1…”

Section: Conflict Of Interest Statementmentioning

confidence: 99%

“…However multiple, papulonodular, tumor‐like (more than 1.5‐cm‐diameter size), indurated, eruptive xanthoma‐like, and acneiform presentations have been described 1 . One study reported a predilection for the extremities 2 . Although very rare in children, CRDD including multifocal forms 3 has been described in pediatric patients 4,5 …”

Section: What Is the Diagnosis?mentioning

confidence: 99%

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Bruised nodule on the leg of a teen

Mija,

Piche,

Kokta

et al. 2023

Pediatric Dermatology

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Bruised nodule on the leg of a teen CASE PRESENTATIONA 17-year-old healthy, overweight girl presented with a two-year history of a single 5-cm non-healing, tender ecchymotic nodule with ill-defined margins on the posterolateral aspect of her left thigh (Figure 1). No history of trauma or medication intake was noted.Complete skin exam was negative for other lesions and there was no lymphadenopathy. Ultrasound revealed a nonspecific 4 x 2 cm subcutaneous heterogeneous mass without peripheral edema. A complete surgical excision of the nodule was performed. Histopathology is shown (Figures 2, 3, safranin stain).

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“…Rosai-Dorfman disease (RDD) which is also known as sinus histiocytosis with massive lymphadenopathy is an uncommon benign non-Langerhans cell histiocytic proliferative disorder of unknown aetiology 1 . It commonly affects lymph nodes with or without extra nodal involvement and massive painless cervical lymphadenopathy is the usual presentation.…”

Section: Introductionmentioning

confidence: 99%

A rare case of pure cutaneous Rosai-Dorfman disease

Marcellin,

Prashanthi,

Dinupa

et al. 2021

tsljd

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Rosai-Dorfman disease (RDD) is a rare but usually benign non-Langerhans cell histiocytic disorder which commonly affects lymph nodes and frequently present with bilateral painless enlarged cervical lymph nodes with systemic symptoms. Although extra nodal tissue involvement is seen in considerable proportion, purely cutaneous involvement without affecting lymph nodes is very rare and forms a diverse clinical entity. Histopathology with immunohistochemical staining remains gold standard in diagnosing this rare entity. Different treatment modalities have been tried in case reports and treatment response is variable. Here we report a case of pure cutaneous RDD in a 21-yearold young female who was referred for staged excision.

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Purely cutaneous rosai-dorfman disease with immunohistochemistry

Cited by 13 publications

References 21 publications

Combined Cutaneous Rosai-Dorfman Disease and Localized Cutaneous Langerhans Cell Histiocytosis Within a Single Subcutaneous Nodule

Combined Cutaneous Rosai-Dorfman Disease and Localized Cutaneous Langerhans Cell Histiocytosis Within a Single Subcutaneous Nodule

Bruised nodule on the leg of a teen

A rare case of pure cutaneous Rosai-Dorfman disease

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