Atypical Phimosis Secondary to a Preputial Metastasis from Rectal Carcinoma

Gbenou, Maximilien C. Goris; Wahidy, Tawfik; Llinares, Karine; Cracco, D; Perrot, Alain; Riquet, D

doi:10.1159/000334747

Cited by 11 publications

(2 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Metastasis is unilateral in only 15% of cases, whereas the corpus spongiosum and glans penis (with skin ulcerative lesions) 71 are each involved in 10% of patients and the prepuce in approximately 5%. 27 , 92 , 99 Exclusive skin lesions are extremely rare according to the most frequent route of dissemination. The high incidence of bilateral involvement is due to the fact that the corpora cavernosa communicate freely through an incomplete midline septum.…”

Section: Discussionmentioning

confidence: 99%

A review of penile metastasis

et al. 2012

View full text Add to dashboard Cite

Penile cancer as primary disease is relatively rare in developed countries. The penis is a rare site of metastases in spite of its rich vascularization. Approximately 500 cases have been reported in the literature; almost 70% of primary lesions are of pelvic origin (from genitourinary or recto-sigmoid primary tumors). We describe a case of penile metastasis from lung cancer. The rarity of the event prompted us to also explore related reviews and discuss the incidence, physiopathology, diagnosis and therapy of penile secondary cancer.

show abstract

Section: Discussionmentioning

confidence: 99%

A review of penile metastasis

et al. 2012

View full text Add to dashboard Cite

show abstract

“…The most common primary malignancies with penis metastases are urogenital cancers (69%); gastrointestinal origin accounts for 19%, with the sigmoid colon and rectum accounting for 12% of all such cases ( 69 ). Although rectal adenocarcinoma is a common malignant tumor of the digestive system, which usually metastasizes to local lymph nodes, the lung, the liver, and bone, penile metastasis from rectal cancer is rare, and these lesions can occur without any liver or lung involvement ( 16 ). Perineal pain, induration, urethral obstruction, priapism, and hematuria are the most common associated symptoms.…”

Section: Discussionmentioning

confidence: 99%

Surgery, radiotherapy, chemotherapy, targeted therapy, and immunotherapy of rectal adenocarcinoma with penile metastasis: a case report

Wang¹,

Shan²,

Zhou³

et al. 2023

J Gastrointest Oncol

View full text Add to dashboard Cite

Background Despite the rich proximity and vascularization to the pelvic organs, metastatic lesions to the penis are incredibly uncommon. Most primary tumors are genitourinary cancers, and rectal origins are rare. Only 56 cases of metastatic penile tumors have been reported since 1870. Several palliative or curative methods, such as chemotherapy, total penectomy, and radiotherapy, have been applied to treat this condition in previous cases; however, the patient prognosis is poor. Immunotherapy is a beneficial treatment approach for multiple cancers, and recent investigations have shown that it may be beneficial for patients with advanced penile cancer. Case Description Herein, we report the case of a 59-year-old Chinese man who had metastatic adenocarcinoma in the penile tissue 3 years after rectal cancer resection. The patient presented with penile pain and dysuria for 6 months when he was 54 years old, and Immunohistochemical staining showed that the origin was the rectum after total penectomy. The patient received surgery, chemotherapy, radiotherapy, targeted therapy and immunotherapy positively and still survived for a further 4 years and 6 months following penectomy despite the late metastasis of rectal cancer. There are two major changes and progress after penectomy, all of which have undergone surgical treatment during continuous treatment and follow-up, the patient completed right inguinal lymphadenectomy when his right regional nodes metastasis was found 23 months after penectomy. While the patient suffered from radiation injury after 47 months after penectomy, which led to radiation necrosis and hip soft tissue infection, and the patient tended to lay prone instead of lying on the back because of the hip pain. The patient ultimately died of multiple organ failure. Conclusions All of the previously reported cases of penile metastasis from rectal cancer since 1870 have been reviewed. Yet, the metastatic prognosis remains poor regardless of the treatment options, except for lesions where metastasis is only limited to the penis. We found that the patient may derive more benefit from strategic therapies including surgery, radiotherapy, chemotherapy, targeted therapy, and immunotherapy.

show abstract