Atypical Mycobacteria Isolated From Clinical Material in South-Eastern Queensland

Dawson, David J.; Reznikov, M.; Blacklock, Zeta M.; Leggo, Janet H.

doi:10.3109/00313027409068979

Cited by 17 publications

(4 citation statements)

References 14 publications

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“…Annual rates of infection in the general population have been in the range of 0.5 to 1 per 100,000; however, significant geographical variability is observed. While in certain areas of the world (Australia, Japan, and southern California, and Virginia in the United States) M. kansasii constitutes a rare isolate (7,12,20,42), regions such as Louisiana in the United States and North Moravia in the Czech Republic report annual rates as high as 2.4 and 17.6 per 100,000 population, respectively (18,43). Since the start of the AIDS epidemic, an increase in M. kansasii disease has been observed (15).…”

Section: The Reservoir and Transmission Route Of Mycobacterium Kansasmentioning

confidence: 99%

Heterogeneity and clonality among isolates of Mycobacterium kansasii: implications for epidemiological and pathogenicity studies

et al. 1997

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The reservoir and transmission route of Mycobacterium kansasii are largely unknown. In addition, culturing of M. kansasii from human sources is not proof of disease because it may represent colonization rather than infection. Unfortunately, investigation of the epidemiology and pathogenicity of M. kansasii is complicated by evidence of heterogeneity within the species. A comprehensive study by detailed genotypic analysis of a large collection of M. kansasii isolates (n = 276) from various geographical sources within Europe was conducted. Five defined subtypes of M. kansasii were identified; of these subtypes, type I represents the most common isolate from humans. Although phylogenetic analysis confirmed its relationship to the other M. kansasii types, significant sequence divergence was found at the 16S-23S intergenic spacer. Analysis of the chromosomal polymorphism of type I demonstrated a marked clonal structure for this particular organism. Because M. kansasii is becoming a significant pathogen among immunodeficient hosts, future epidemiological and pathogenicity studies should take into consideration both the heterogeneity within the species and the apparent clonality of the most prevalent M. kansasii isolates infecting humans.

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Section: The Reservoir and Transmission Route Of Mycobacterium Kansasmentioning

confidence: 99%

Heterogeneity and clonality among isolates of Mycobacterium kansasii: implications for epidemiological and pathogenicity studies

et al. 1997

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“…The number of pulmonary infections caused by M. kansasii also rose during those periods (501). M. kansasii infections are rare in Australia (123). In British Columbia, the number of M. avium complex infections far exceeds the number due to M. kansasii (246).…”

Section: Epidemiology Of M Kansasii Infectionmentioning

confidence: 99%

Epidemiology of Infection by Nontuberculous Mycobacteria

Martin

Parker²,

Falkinham

1987

Am Rev Respir Dis

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“…Methods for decontamination, microscopy, and culture have been described elsewhere (Dawson et al, 1974). Acid-fast isolates were identified as belonging to a species or a species complex with the aid of a panel of standard tests, i.e., growth rates at 25,32,37 and 43 T; pigment production in light and dark conditions at 37 C: production of niacin; hydrolysis of 'Tween 80' at 5 and 10 d; reduction of nitrate; hydrolysis of urea, nicotinamide, and pyrazinamide; sensitivity to anti-mycobacterial agents, including thiophen-2-carboxylic acid hydrazide; hydrolysis of phenolphthalein sulphate at 3 and 14 d; and reduction of ferric ammonium citrate.…”

Section: Methodsmentioning

confidence: 99%