Atypical Manifestations of Chronic Q Fever

Hatchette, Todd F.; Marrie, Thomas J.

doi:10.1086/323031

Cited by 25 publications

(20 citation statements)

References 37 publications

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“…Q fever has reportedly been associated with abdominal aortic aneurysm, aortoenteric fistula, lower limb fistula, vascular graft infection, vertebral body erosions, CNS infection, fever of unknown origin, and possible pancreatitis [3,4,[7][8][9][10]. Mass lesions are one of the rarest presentations of Q fever.…”

Section: Discussionmentioning

confidence: 99%

“…Common manifestations of persistent localized Q fever infection include endocarditis, infectious thoracoabdominal aortic aneurysm, vascular graft infection, bone lesions, pulmonary infection, and granulomatous hepatitis. Encephalitis, pericarditis, and myocarditis have also been reported [3,4]. In addition, there are rare reports of Coxiella burnetii infection presenting as mass lesions in the lung, mimicking malignant tumors radiographically [5,6].…”

Section: Introductionmentioning

confidence: 99%

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321 Q Fever Presented as a Large Retroperitoneal Pseudotumoral Mass

Nowroozizadeh

Mehmandari

Gallegos

et al. 2018

American Journal of Clinical Pathology

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Background. Q fever is an infection caused by Coxiella burnetii, an intracellular organism. Acute infection is most often a benign and asymptomatic process; however, some individuals may go on to develop subacute and persistent localized symptomatic Q fever. As such, the clinical and histopathologic findings of Q fever are widely variable and may be missed if clinical suspicion is not high. Case Presentation. Herein we report the first case of C. burnetii infection presenting as an isolated retroperitoneal mass. A 61-year-old male underwent axillary-bifemoral bypass surgery. His postoperative course was complicated by the discovery of a large retroperitoneal mass. Conclusion. Clinical and histopathologic findings of Coxiella burnetii infection are variable and can be deceiving. These are often nonspecific, especially in its persistent localized infectious stages.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

321 Q Fever Presented as a Large Retroperitoneal Pseudotumoral Mass

Nowroozizadeh

Mehmandari

Gallegos

et al. 2018

American Journal of Clinical Pathology

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“…Chronic Q fever is associated with high levels of specific antibodies to C. burnetii phase I, whereas acute Q fever is characterized by a predominance of antibodies to C. burnetii phase II [4,5]. Most cases of chronic Q fever are diagnosed by detection of specific antibodies, with the microimmunofluorescence test being the reference technique [4,6].…”

Section: Discussionmentioning

confidence: 99%

Coxiella burnetii infection of an aortic graft: surgical view and a word of caution

Georghiou

Hirsch

Vidne

et al. 2004

Interactive Cardiovascular and Thoracic Surgery

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A 30-year-old-man presented with an aortic graft infection. Polymerase chain reaction study identified the infectious organism as Coxiella burnetii, a strictly intracellular pathogen that causes Q fever in humans. The patient was successfully treated by removal of the infected graft, implantation of homograft aortic tube, and specific antibiotic therapy. He is doing well after 6 months, with no evidence of recurrent homograft infection on transthoracic echocardiography. C. burnetii vascular graft infections may be underdiagnosed because of lack of recognition. We suggest that serologic tests for C. burnetii be routinely performed in the presence of unexplained febrile illness or pain in patients with a history of underlying vascular disease.

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“…In nature, C. burnetii expresses phase I antigen. After many passages through tissue culture, the microorganism undergoes a phase variation and expresses phase II antigen (Hatchette and Marrie 2001;Hussein et al 2001;Toman et al 2003). Acute Q fever is characterized by high levels of anti-phase II Ab(s) whereas chronic Q fever is characterized by increasing titers of both anti-phase I and anti-phase II Ab(s) (Musso and Raoult 1995).…”

Section: Ab(s) Antibody(ies) Igg Immunoglobulin Gmentioning

confidence: 99%

Seroprevalence of Coxiella burnetii antibodies among students of the Faculty of Medicine in Košice (Slovakia)

2008

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Titers of immunoglobulin IgG against phases I and II of Coxiella burnetii were determined in 241 students of the Faculty of Medicine by ELISA method and the respective risk factors were evaluated, e.g., rural and urban life, consumption of milk, contact with animals and gender, which may be associated with exposure to C. burnetii. Phase I antibodies (Abs) were detected in 59 serum samples (24.4 %) at antibody level of 1: 100-1: 400. Phase II Abs were found in 179 persons (74.2 %). The titers were in the range of 1: 100-1: 1600. The titer > or =1: 800 of IgG was used as a cut-off level, and was detected only in 20 students (8.2 %). No significant difference in the prevalence of Abs was detected either between the students living in rural and urban environment (78.8 and 73.2 %, respectively) or between males and females (74.0 and 74.7 %, respectively). Abs were detected more frequently in raw milk consumers (68.1 %) and in students who kept some animals (73.7 %).

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Atypical Manifestations of Chronic Q Fever

Cited by 25 publications

References 37 publications

321 Q Fever Presented as a Large Retroperitoneal Pseudotumoral Mass

321 Q Fever Presented as a Large Retroperitoneal Pseudotumoral Mass

Coxiella burnetii infection of an aortic graft: surgical view and a word of caution

Seroprevalence of Coxiella burnetii antibodies among students of the Faculty of Medicine in Košice (Slovakia)

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