Seroprevalence of Coxiella burnetii antibodies among students of the Faculty of Medicine in Košice (Slovakia)

Dorko, Erik; Kalinová, Z.; Pilipčinec, E.

doi:10.1007/s12223-008-0090-2

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…Human infections with C. burnetii have been reported in many European countries (Pascual-Velasco et al 1998, Cisak et al 2003, Cardenosa et al 2006, Dorko et al 2008, McCaughey et al 2008, Hamzic et al 2008, Monno et al 2009), including Croatia. In Croatia, Q fever was first described in 1950 (Mihaljevic 1950).…”

Section: Introductionmentioning

confidence: 99%

Prevalence ofCoxiella burnetiiAntibodies Among Febrile Patients in Croatia, 2008–2010

Vilibić-Čavlek

Kučinar

Ljubin‐Sternak

et al. 2012

Vector-Borne and Zoonotic Diseases

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Despite the widespread distribution of Q fever, the prevalence in humans is not accurately known, because many infected people seroconvert without symptoms or with a mild febrile disease. The aim of this study was to determine the seroprevalence of Q fever in different regions of Croatia. During a 2-year period (2008-2010), serum samples from 552 febrile patients with prolonged cough aged 1-88 were tested for the presence of Coxiella burnetii antibodies by using indirect immunofluorescent assay. Sera from 27.5% patients showed IgG antibodies. Serological evidence of C. burnetii infection was found in patients from all parts of Croatia. Seroprevalence rates significantly differed among regions from 21.5% to 41.2% (p=0.001). Men were more often seropositive (31.6%) than women (22.2%; p=0.016). According to age, a progressive increase in the IgG seropositivity rates was observed as ranging from 6.7% in children less than 10 years of age to 39.2% in patients aged 40-49 (p=0.001). Above the age of 50, the IgG seroprevalence remained stable. Patients from rural areas were more often seropositive than patients from urban areas (40.8% vs. 19%), p<0.001). Acute Q fever was confirmed in 5.8% of patients. Cases occurred throughout the year. A majority of cases were reported during summer months.

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Section: Introductionmentioning

confidence: 99%

Prevalence ofCoxiella burnetiiAntibodies Among Febrile Patients in Croatia, 2008–2010

Vilibić-Čavlek

Kučinar

Ljubin‐Sternak

et al. 2012

Vector-Borne and Zoonotic Diseases

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“…This is a younger demographic than a recent study of notified Q fever cases in NSW conducted from 2001 to 2010 that found the majority of (75.0% of all notifications) cases were men, aged between 40 and 59 years (Lowbridge et al 2012). That study showed similar risks associated with adults and occupational contact with livestock as a wide range of studies around the world (these includes farmers, veterinarians, abattoirs, school students and teachers, inseminators and hoof trimmers) (Abe et al 2001;Alkan et al 1973;Amitai et al 2010;Berktaş et al 2011;Bernard et al 2012;Bosnjak et al 2010;Cetinkaya et al 2000;Dal Pozzo et al 2016;de Rooij et al 2012;Dorko, Kalinova & Pilipcinec 2008;Dorko et al 2011;Fenga et al 2015;Valencia et al 2000;Van den Brom et al 2013;Whitney et al 2009).…”

Section: Discussionmentioning

confidence: 74%

The epidemiology of Q fever in Queensland, Australia and effectiveness of vaccination for prevention

Woldeyohannes¹

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Q fever, caused by the small obligate intracellular, gram-negative pathogenic bacterium Coxiella burnetii, is primarily an occupationally-acquired zoonotic disease most commonly reported in people working in the livestock and meat industries who have direct or indirect contact with infected animals. The main preventive tool for Q fever is a vaccine (Q-VAX ® , Seqirus, Australia) that is recognised to be highly effective and providing long lasting protection. Its implementation requires pre-vaccination screening tests using serology and skin tests conducted in parallel. This is because the vaccine has more side effects in persons who have already had the disease Q fever, so testing for prior immunity is necessary before vaccination to avoid unwanted vaccine side effects. However, outbreaks of Q fever continue to be recorded in abattoirs and Q fever continues to be an important public health issue in Australia. The incidence of Q fever remains high especially in Queensland and New South Wales (NSW) though there is good evidence of improved Q fever control as a result of the implementation of the Q fever vaccination program. There is evidence that the Q fever vaccination has not been fully implemented because of the high incidence of Q fever among individuals targeted by past vaccination program.Therefore, this PhD thesis was mainly intended to assess the overall effectiveness of the Q fever vaccination program, and the associated Q fever notification and hospital admission rates, and the most risky exposures for the occurrence of Q fever in Queensland, Australia. Chapter 1 presents a literature review on Q fever at global and Australia levels. In chapter 2, I conducted a systematic review and meta-analysis on the seroprevalence of Q fever. Chapter 3 addresses estimation of vaccine failure rate and duration of immunity for Q fever using Cox proportional hazard model. I then explicitly addressed the accuracy of the Q fever pre-screening test using Bayesian latent class analysis in chapter 4. In chapter 5, I assessed the demographic and vaccination status factors associated with the incidence of Q fever infection using a case control design. In chapter 6, I modelled the rate of Q fever notification and hospitalization, and identified the associated factors using Poisson and Negative Binomial regression models. In chapter 7, I conducted a risk assessment using the enhanced Q fever exposure surveillance data using multiple correspondence analysis (MCA) technique. Finally, chapter eight highlight key findings, discuss them, and summarize the thesis.In summary, the results presented in this Thesis, address the knowledge gap regarding the incidence of Q fever in vaccinated individuals and the duration of immunity of the Q fever vaccine and the accuracy of the prescreening tests thereby addressing the overall effectiveness of the Q fever vaccination program and the resulting Q fever notification and admission rates in the Queensland. It presents evidence of the protective effect of being vaccinated using the Q fever vaccine...

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Q Fever: Current State of Knowledge and Perspectives of Research of a Neglected Zoonosis

Porter

Czaplicki²,

Mainil

et al. 2011

International Journal of Microbiology

179

195

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Q fever is an ubiquitous zoonosis caused by an resistant intracellular bacterium, Coxiella burnetii. In certain areas, Q fever can be a severe public health problem, and awareness of the disease must be promoted worldwide. Nevertheless, knowledge of Coxiella burnetii remains limited to this day. Its resistant (intracellular and environmental) and infectious properties have been poorly investigated. Further understanding of the interactions between the infected host and the bacteria is necessary. Domestic ruminants are considered as the main reservoir of bacteria. Infected animals shed highly infectious organisms in milk, feces, urine, vaginal mucus, and, very importantly, birth products. Inhalation is the main route of infection. Frequently asymptomatic in humans and animals, Q fever can cause acute or chronic infections. Financial consequences of infection can be dramatic at herd level. Vaccination with inactive whole-cell bacteria has been performed and proved effective in humans and animals. However, inactive whole-cell vaccines present several defects. Recombinant vaccines have been developed in experimental conditions and have great potential for the future. Q fever is a challenging disease for scientists as significant further investigations are necessary. Great research opportunities are available to reach a better understanding and thus a better prevention and control of the infection.

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Seroprevalence of Coxiella burnetii antibodies among students of the Faculty of Medicine in Košice (Slovakia)

Cited by 3 publications

References 18 publications

Prevalence ofCoxiella burnetiiAntibodies Among Febrile Patients in Croatia, 2008–2010

Prevalence ofCoxiella burnetiiAntibodies Among Febrile Patients in Croatia, 2008–2010

The epidemiology of Q fever in Queensland, Australia and effectiveness of vaccination for prevention

Q Fever: Current State of Knowledge and Perspectives of Research of a Neglected Zoonosis

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