Atypical indocyanine green angiography findings after indocyanine green-assisted internal limiting membrane peeling

Triazole-derivatized near-infrared cyanine dyes enable local functional fluorescent imaging of ocular inflammation

“…The lens capsule is rich in hydrophobic collagen type IV and sulphated glycosaminoglycan and the iris contains high levels of melanin, which has been shown to bind several drugs including ephedrine (Danysh and Duncan, 2009;Agrahari et al, 2016). ICG has high affinity for extracellular matrix components (e.g., collagen) and has been used in the past during ophthalmic surgery to stain the transparent, acellular internal limiting membrane at the interface between the vitreous and retina (Mavrofrides et al, 2006;Noguchi et al, 2018). We have shown that very small amounts of TNC dyes relocate in the vitreous, which suggests that they can penetrate both the anterior and posterior portion of the eye but at very small amounts and thus would likely require tweaks to the structure or an additional agent for optimal delivery to some specific regions of the eye (Pescina et al, 2018).…”