Atypical immunoproliferative disorders: When of age?

Frizzerà, Glauco

doi:10.1007/bf01608333

Cited by 6 publications

(3 citation statements)

References 34 publications

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“…Nodal atypical lymphoproliferation with diffuse pseudoobliterative pattern (13,14), but not a lymphoma, was concomitantly observed in the sample from patient 1 (31). Pseudoobliteration of the lymph node architecture was present, with partially discernible compartments showing some preserved germinal centers and diffuse lymphoplasmacytoid and immunoblastic infiltration, associated with clusters of epithelioid cells and occasional CCL cells.…”

Section: Resultsmentioning

confidence: 84%

“…A more or less pronounced lymphoepithelial aggressiveness is present in MALT sites, without definite evidence of B cell malignancy. With reference to the parotid, gastric, and nodal microenvironments, we used the more specific terms, myoepithelial sialadenitis (MESA) (3,4,16,17), grade 3 or grade 4 gastric lymphoid infiltrates (18), and atypical lymphoproliferative disorder (13,14), respectively. Patients defined as having an SS-associated lymphoproliferative disorder had to show pathologic evidence of a lymphoproliferative lesion.…”

Section: Methodsmentioning

confidence: 99%

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Characterization of prelymphomatous stages of B cell lymphoproliferation in Sjögren's syndrome

Vita

Boiocchi

Sorrentino

et al. 1997

Arthritis & Rheumatism

105

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Objective. To determine whether the prelymphomatous stages of B cell lymphoproliferation in Sjögren's syndrome (SS) may be better characterized by the integration of clinical, pathologic, and molecular data, the latter focusing on the expansion, persistence, and dissemination of clonal B cells in the course of the disease. Methods. Multiple tissue lesions (synchronous from different tissues and metachronous from the same tissue) were evaluated in biopsy specimens obtained from 6 consecutive patients with SS who had an associated lymphoproliferative disorder. Fully benign gastric lesions were evaluated in tissue from an additional 11 patients with SS who had no associated lymphoproliferative disorder. Multiple and complementary molecular analyses of B cell clonality were used: Southern blot, polymerase chain reaction, single‐strand conformation polymorphism, DNA sequencing, and hybridization with clonospecific oligoprobes. All the patients were then strictly followed up for the appearance of lymphoma. Results. Different scenarios of SS‐associated B cell lymphoproliferation were identified: 1) the ongoing expansion of the same dominant clone, localized or disseminated, in tissue from 2 patients, 1 of whom later developed an overt B cell lymphoma; 2) different dominant clones in different synchronous or metachronous tissues from the remaining 4 patients with an associated lymphoproliferative disorder; and 3) small oligoclonal expansions in 7 of the 11 benign gastric lymphoid infiltrates. Conclusion. Prelymphomatous B cell lymphoproliferation in SS was better characterized following integration of the findings. The different types of B cell clonal expansion (oligoclonal or monoclonal, smaller or larger in size, fluctuating or established, localized or disseminated) may imply a different risk of lymphoma progression. An accurate clinical, histopathologic, and molecular characterization may therefore be crucial in future studies aimed at clarifying the pathobiology of SS‐associated lymphoproliferation.

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Section: Resultsmentioning

confidence: 84%

Section: Methodsmentioning

confidence: 99%

Characterization of prelymphomatous stages of B cell lymphoproliferation in Sjögren's syndrome

Vita

Boiocchi

Sorrentino

et al. 1997

Arthritis & Rheumatism

105

View full text Add to dashboard Cite

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“…HIV with HHV-8 leads to aggressive and often fatal cases of MCD in western countries [ 17 – 19 ], and is believed to do so by producing a homolog to IL-6, whereas MCD is seen in patients free of HIV and HHV-8 in Japan [ 5 , 11 ].…”

Section: Discussionmentioning

confidence: 99%

Castleman's disease with TAFRO syndrome: a case report from Syria

Alhoulaiby

Ahmad

Alrstom

et al. 2017

Oxford Medical Case Reports

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Castleman's disease is a rare disorder, yet a rarer newly described syndrome called TAFRO syndrome was discovered to accompany it. TAFRO represents the constellation of symptoms (Thrombocytopenia, Anasarca, MyeloFibrosis, Renal failure, Organomegaly). Most cases were described in Japan. We present the first case of TAFRO syndrome in Syria. A 58-year-old Caucasian male with no relevant history presented with fatigue, oliguria, decreased platelets, increased creatinine level, hepatosplenomegaly, ascites, pitting edema and lymph node enlargement. Possible differential diagnoses were excluded by laboratory, radiologic and cytologic tests including TB, malignancy and autoimmune diseases. A biopsy of a supraclavicular lymph node confirmed Castleman disease. Our patient had Catleman's disease, and presented with only four diagnostic criteria for TAFRO syndrome (Myelofibrosis was absent) in addition to other minor characteristics (microcytic anemia, negative HIV and HHV-8 infections.) which make the presentation consistent with TAFRO syndrome described in the Japanese cases. The criteria for diagnosing TAFRO syndrome are still changing, and the pathophysiology behind it is unclear. We recommend further research to understand this syndrome taking into account that its prevalence might be worldwide.

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Sialadenitis

Seifert

1996

Oralpathologie I

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Atypical immunoproliferative disorders: When of age?

Cited by 6 publications

References 34 publications

Characterization of prelymphomatous stages of B cell lymphoproliferation in Sjögren's syndrome

Characterization of prelymphomatous stages of B cell lymphoproliferation in Sjögren's syndrome

Castleman's disease with TAFRO syndrome: a case report from Syria

Sialadenitis

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