Atypical Herpes Simplex Presenting Necrotizing Granulomas in an Immunocompromised Patient

Sarcoidosis is a systemic granulomatous disease of unknown cause characterized by a wide variety of presentations. Its diagnosis is based on three major criteria: a clinical presentation compatible with sarcoidosis, the presence of non-necrotizing granulomatous inflammation in one or more tissue samples, and the exclusion of alternative causes of granulomatous disease. Many conditions may mimic a sarcoid-like granulomatous reaction. These conditions include infections, neoplasms, immunodeficiencies, and drug-induced diseases. Moreover, patients with sarcoidosis are at risk of developing opportunistic infections or lymphoma. Reliably confirming the diagnosis of sarcoidosis and better identifying new events are major clinical problems in daily practice. To address such issues, we present seven emblematic cases, seen in our department, over a ten-year period along with a literature review about case reports of conditions misdiagnosed as sarcoidosis.

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Atypical Herpes Simplex Presenting Necrotizing Granulomas in an Immunocompromised Patient

Cited by 3 publications

References 9 publications

Update in Infectious Disease Diagnosis in Anatomic Pathology

Update in Infectious Disease Diagnosis in Anatomic Pathology

Cutaneous granulomas associated with rubella virus: A clinical review

Challenging Mimickers in the Diagnosis of Sarcoidosis: A Case Study

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