Cutaneous granulomas associated with rubella virus: A clinical review

Surveillance for rubella virus in samples obtained from non‐immunodeficient individuals

“…5,8 One hypothesis regarding the role of RuV in chronic inflammation is that it enters into a silent reservoir shortly after immunization/infection and emerges under illdefined circumstances where it causes or contributes to chronic inflammation. 6,9 Over 100 cases of vaccine strain RuV (referred to as vaccine-derived rubella virus (VDRV))-associated inflammation have been identified through a combination of fluorescent immunohistochemistry (fIHC), reverse-transcriptase polymerase chain reaction (RT-PCR), sequencing, and culture of VDRV from fresh tissue. 5 This phenomenon was originally described in cutaneous granulomas in people with recognized inborn errors of immunity, and the majority of samples submitted for analysis come from patients with known inborn errors of immunity and cutaneous granulomas.…”