Atypical fibroxanthomas of the skin

Kempson, Richard L.; McGavran, Malcolm H.

doi:10.1002/1097-0142(196411)17:11<1463::aid-cncr2820171114>3.0.co;2-e

Cited by 138 publications

(57 citation statements)

References 8 publications

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“…In 1963, the term, 'atypical fibroxanthoma (AFX, pseudosarcoma of the skin, paradoxical fibrosarcoma, pseudosarcomatous dermatofibroma, pseudosarcomatous xanthofibroma and pseudosarcomatous reticulohistiocytoma)' was proposed by Helwig for a lesion that was initially viewed as a reactive process [1][2][3]. In 1973, AFX was established as a distinct clinicopathologic entity [3].…”

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confidence: 99%

Atypical fibroxanthoma: new insights

Hussein

2014

Expert Review of Anticancer Therapy

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Atypical fibroxanthoma (AFX) is an ultraviolet radiation-associated dermal neoplasm. To address the clinicopathologic and molecular features of this particular neoplasm. The author conducted a literature review using PubMed searching for articles relating to AFX. AFX usually appears as a rapidly growing nodular or nodulo-ulcerative lesion. It occurs on sun-exposed skin of elderly peoples. AFX may be composed predominantly of pleomorphic, spindle, epithelioid cells, or admixture of these cells. The differential diagnosis of AFX includes pleomorphic dermal sarcoma, squamous cell carcinoma, malignant melanoma and leiomyosarcoma. Several observations favor a mesenchymal origin for AFX. These reviews address the clinicopathologic features, molecular pathology, prognosis and treatment of this neoplasm.

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confidence: 99%

Atypical fibroxanthoma: new insights

Hussein

2014

Expert Review of Anticancer Therapy

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“…AFX typically has no clinical features that distinguish it from other primary cutaneous neoplasms such as squamous and basal cell carcinomata and malignant melanoma (Fretzin and Helwig, 1973;Helwig and May, 1986;Kempson and McGavran, 1964;Rice et al, 1991). It usually presents as a firm, sometimes ulcerated nodule on actinically damaged skin of the head and neck in the elderly (Fretzin and Helwig, 1973;Kempson and McGavran, 1964).…”

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confidence: 99%

“…It usually presents as a firm, sometimes ulcerated nodule on actinically damaged skin of the head and neck in the elderly (Fretzin and Helwig, 1973;Kempson and McGavran, 1964). Ears, cheeks and nose are the most common sites (Fretzin and Helwig, 1973).…”

Section: Commentmentioning

confidence: 99%

“…Ears, cheeks and nose are the most common sites (Fretzin and Helwig, 1973). The tumour characteristically follows a benign clinical path (Fretzin and Helwig; Helwig and May, 1986; Kempson and McGavran, 1964) but recurrences (Fretzin and Helwig;Helwig and May, 1986) at and metastases (Fretzin and Helwig; Helwig and May, 1986) from the above sites have been reported. Metastases mostly involved the structures in the region of the parotid gland (Helwig and May, 1986).…”

Section: Commentmentioning

confidence: 99%

“…Metastases mostly involved the structures in the region of the parotid gland (Helwig and May, 1986). Postulated predisposing factors to the development of AFX are solar damage to the skin (Fretzin and Helwig, 1973;Kempson and McGavran, 1964), antecedent trauma to the area and previous irradiation (Fretzin and Helwig, 1973;Kempson and McGavran, 1964).…”

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confidence: 99%

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Paraffin Histology Sections and Delayed Repair in Recurrent Atypical Fibroxanthoma of the Eyelid

Paramanathan¹,

Gal²,

Benger³

2009

Orbit

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We present a report of a recurrent atypical fibroxanthoma (AFX), a tumour known rarely to involve the eyelid. A 61 year-old male was referred after reappearance of a lower eyelid AFX within two months of resection. The neoplastic spindle cells at the periphery of an AFX may be difficult to differentiate from dermal fibroblasts in frozen sections. Paraffin sections provide better histological definition and thus greater accuracy in determining completeness of excision. The patient's recurrent tumour was surgically excised and overnight paraffin sections were used to obtain margin clearance, before secondary reconstruction. The tumour required re-excision on three occasions before clearance was achieved. The patient remains tumour free at 12 months' follow-up.

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Intravenous atypical vascular proliferation. A cutaneous lesion simulating a malignant blood vessel tumor

Rosaí¹,

Akerman²

1974

Archives of Dermatology

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Atypical fibroxanthomas of the skin

Cited by 138 publications

References 8 publications

Atypical fibroxanthoma: new insights

Atypical fibroxanthoma: new insights

Paraffin Histology Sections and Delayed Repair in Recurrent Atypical Fibroxanthoma of the Eyelid

Intravenous atypical vascular proliferation. A cutaneous lesion simulating a malignant blood vessel tumor

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