Atypical fibroxanthoma with prominent sclerosis

Bruecks, Andrea K.; Medlicott, Shaun; Trotter, Martin J.

doi:10.1034/j.1600-0560.2003.00077.x

Cited by 29 publications

(15 citation statements)

References 23 publications

(26 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, regression was described in 7 AFX in abstract form 47 but was alluded to earlier in a single case of highly sclerotic AFX. 48 The concept of regression in AFX deserves further attention and may partly explain the generally small size and indolent behavior of these tumors, despite their alarming histological appearances. Perineural or intraneural invasion appear to be rare events in AFX, if indeed they occur at all.…”

Section: Discussionmentioning

confidence: 98%

Atypical Fibroxanthoma: A Histological and Immunohistochemical Review of 171 Cases

Beer¹,

Drury²,

Heenan³

2010

The American Journal of Dermatopathology

121

140

View full text Add to dashboard Cite

The clinical and histological features of 171 atypical fibroxanthomas (AFX) from a single institution in Western Australia are outlined. This area experiences high levels of solar radiation, and all assessable biopsies showed solar elastosis. Patients were aged between 41 and 97 years (median age 74), with 76% of tumors occurring in men (male to female ratio approximately 3 to 1). Most tumors were small, with a median diameter of 10 mm and a range of 4-35 mm. Only 5% exceeded 20 mm in diameter. Most AFX were well-circumscribed dermal lesions, with limited invasion of subcutis in a minority. Histological variants identified included keloidal (n = 8), clear cell (n = 3), and granular cell (n = 3), plaque like (n = 4), and myxoid (n = 1). Bland cytological appearances (spindle cell nonpleomorphic AFX) were noted in 5 tumors, with osteoclast-like giant cells in 2. Features suggesting regression were present in 22 cases. Two cases recurred locally, none metastasized. No tumors expressed melanocytic or epithelial markers. Seventy-four percent of cases expressed smooth muscle actin, typically strongly and diffusely. No AFX stained with desmin. Only 1 of 50 cases was CD117 positive. In conclusion, AFX may show a wide range of histological appearances, and a panel of immunohistochemical markers is essential to make the correct diagnosis. Histological mimics, such as poorly differentiated squamous cell carcinoma, must be carefully excluded. Specific diagnosis is important because there seems to be a very low risk of recurrence or metastasis despite the frequently alarming histology.

show abstract

Section: Discussionmentioning

confidence: 98%

Atypical Fibroxanthoma: A Histological and Immunohistochemical Review of 171 Cases

Beer¹,

Drury²,

Heenan³

2010

The American Journal of Dermatopathology

121

140

View full text Add to dashboard Cite

show abstract

“…Many histological variants of AFX have been described, including clear cell, 10–12 granular cell, 13–15 chondroid, 16 pigmented 17 and AFX with osteoclast‐like giant cells 18,19 . A single case with prominent sclerosis has been described in AFX with acellular hyalinization replacing large areas of the tumor 20 . In this study, we report a series of AFXs with keloidal‐type collagen admixed with the pleomorphic tumor cells.…”

mentioning

confidence: 85%

Keloidal atypical fibroxanthoma: a case series

Kim¹,

McNiff

2009

J Cutan Pathol

View full text Add to dashboard Cite

show abstract

“…Secondary changes are quite uncommon and they include the presence of clear, granular, pigmented and osteoclast-like giant cells [16]. The stroma may have focal osteoid, chondroid, myxoid [17], hemosiderotic, hemorrhagic, desmoplastic, hyalinized, sclerotic, keloidal and pseudoangiomatous changes [3,13,15,[18][19][20][21][22]. Representative examples of AFX are shown in FIGURES 1-4.…”

Section: Clinical Features Of Afxmentioning

confidence: 97%

Atypical fibroxanthoma: new insights

Hussein

2014

Expert Review of Anticancer Therapy

View full text Add to dashboard Cite

Atypical fibroxanthoma (AFX) is an ultraviolet radiation-associated dermal neoplasm. To address the clinicopathologic and molecular features of this particular neoplasm. The author conducted a literature review using PubMed searching for articles relating to AFX. AFX usually appears as a rapidly growing nodular or nodulo-ulcerative lesion. It occurs on sun-exposed skin of elderly peoples. AFX may be composed predominantly of pleomorphic, spindle, epithelioid cells, or admixture of these cells. The differential diagnosis of AFX includes pleomorphic dermal sarcoma, squamous cell carcinoma, malignant melanoma and leiomyosarcoma. Several observations favor a mesenchymal origin for AFX. These reviews address the clinicopathologic features, molecular pathology, prognosis and treatment of this neoplasm.

show abstract

Atypical fibroxanthoma with prominent sclerosis

Abstract: Rarely, AFX may exhibit marked sclerosis with areas of complete replacement of tumor by hyalinized collagen. In a small biopsy, such hyalinization may be a diagnostic pitfall leading to an erroneous diagnosis.

Cited by 29 publications

References 23 publications

Atypical Fibroxanthoma: A Histological and Immunohistochemical Review of 171 Cases

Atypical Fibroxanthoma: A Histological and Immunohistochemical Review of 171 Cases

Keloidal atypical fibroxanthoma: a case series

Atypical fibroxanthoma: new insights

Contact Info

Product

Resources

About