2013
DOI: 10.1590/s2237-60892013000300002
|View full text |Cite
|
Sign up to set email alerts
|

Atypical antipsychotics in the treatment of pathological aggression in children and adolescents: literature review and clinical recommendations

Abstract: Objective: To review the literature about the use of atypical antipsychotics in the treatment of pathological aggression in children and adolescents. Method: The databases MEDLINE, SciELO, and LILACS were searched for publications in Portuguese or English from 1992 to August 2011 using the following keywords: mental disease, child, adolescent, treatment, atypical antipsychotic, aggressive behavior, aggression, and violent behavior. Results: Sixty-seven studies of good methodological quality and clinical intere… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

1
6
0
2

Year Published

2017
2017
2020
2020

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 10 publications
(9 citation statements)
references
References 60 publications
(88 reference statements)
1
6
0
2
Order By: Relevance
“…Risperidone, a benzisoxazole derivative, is one of the SGAs with selective antagonistic properties at 5‐HT2c receptors . Over the past two decades, risperidone has been used to effectively treat a broad spectrum of psychiatric disorders . Indeed, risperidone is the most commonly prescribed antipsychotic medication among children and adolescents with bipolar disorder, schizophrenia, and attention‐deficit/hyperactivity disorder (ADHD)…”
Section: Introductionmentioning
confidence: 99%
“…Risperidone, a benzisoxazole derivative, is one of the SGAs with selective antagonistic properties at 5‐HT2c receptors . Over the past two decades, risperidone has been used to effectively treat a broad spectrum of psychiatric disorders . Indeed, risperidone is the most commonly prescribed antipsychotic medication among children and adolescents with bipolar disorder, schizophrenia, and attention‐deficit/hyperactivity disorder (ADHD)…”
Section: Introductionmentioning
confidence: 99%
“…Reviewing a meta‐analysis that evaluates the research findings on different psychotropic medications is useful for gaining an overview of the various classes of medications. Teixeira, Jacintho, Celeri and Dalgalarrondo (), who review research on each atypical antipsychotic medication, provide one such resource. In addition, in their respective works, Whitaker (), Gottstein, Olfman and Robbins (), and Olfman and Robbins () discuss the negative effects of antipsychotics and other psychotropics on children and adults.…”
Section: Practice Guidelinesmentioning
confidence: 99%
“…Although there is evidence that antipsychotics and anticonvulsants reduce maladaptive aggression in children and adolescents [13], recent studies have called for more extensive preclinical investigation to address whether these medications specifically lessen maladaptive aggression in youth, and how aggressive behaviors are modulated by these substances [21]. Existing data is often complicated by factors such as polypharmacy, concurrent treatments, variations in psychiatric presentation and diagnoses, as well as social dynamics [50]. From a preclinical perspective, our adolescent animal model of maladaptive aggression can inform clinical practice by isolating reactive aggressive phenotypes from confounding variables that complicate human research.…”
Section: Introductionmentioning
confidence: 99%