Atypical and Malignant Neoplasms Showing Lipomatous Differentiation

Azumi, Norio; Curtis, Jeffrey L.; Kempson, Richard L.; Hendrickson, Michael

doi:10.1097/00000478-198703000-00001

Cited by 175 publications

(74 citation statements)

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“…We summarized the results of several studies that investigated dedifferentiation and found that only 1% (8 of 258) of ALTs of the extremities underwent dedifferentiation, whereas 26% (22 of 86) of well differentiated liposarcomas of the retroperitoneum underwent dedifferentiation. 2,6,19,[22][23][24][25] In the current study, we identified a single case (2%) that underwent dedifferentiation. Therefore, our results are in line with the results from other studies.…”

Section: Discussionmentioning

confidence: 98%

“…The reported rates of local disease recurrence in other studies ranges from 5% to 52%. 19,[21][22][23] The median follow-up period in our series was 51 months of patients with ALT, whereas the median time to local disease recurrence was 48 months. Therefore, the estimate of local disease recurrence in our series likely underestimates the true rate of local disease recurrence, which will likely increase over time.…”

Section: Discussionmentioning

confidence: 99%

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Deep‐seated, well differentiated lipomatous tumors of the chest wall and extremities

Bassett

Schuetze

Distèche

et al. 2005

Cancer

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BACKGROUND Intramuscular lipomas and atypical lipomatous tumors (ALT) are common deep‐seated lipomatous tumors of the chest wall and extremities. Distinguishing between these two entities can be difficult based on histologic analysis alone. However, the cytogenetic profiles of ALT and intramuscular lipomas are distinct. Correct classification is important, because aggressive local disease recurrence occurs more frequently in patients with ALT than in patients with intramuscular lipoma. The authors examined their single institutional experience and correlated their classification with clinical features and outcome. METHODS In the current study, 106 patients with deep‐seated, well differentiated adipose tumors of the chest wall and extremities were classified as having ALT or intramuscular lipoma using a combined approach of histology and cytogenetics, if available. The classification was correlated with clinicopathologic features and follow‐up data. RESULTS Fifty‐five patients were classified as having intramuscular lipoma and 51 were classified as having ALT. Classification did not correlate with age and gender (P = 0.28 and P = 0.96, respectively). Intramuscular lipomas were smaller than ALTs (P < 0.0001), but there was significant overlap between the 2 groups. ALT occurred preferentially in the lower extremity (P < 0.0009). Four percent of patients with intramuscular lipomas and 27% of patients with ALTs developed local disease recurrence (P = 0.0006). Disease recurrence did not correlate with patient age at diagnosis, patient gender, tumor size, and tumor location (P = 0.45, P = 0.26, P = 0.49, and P = 0.28, respectively). Within the subset of patients with ALTs, disease recurrence did not correlate with patient age at diagnosis, patient gender, or tumor location (P = 0.38, P = 0.54, and P = 0.86, respectively). CONCLUSIONS Classification of deep‐seated, well differentiated lipomatous tumors of the extremities and chest wall using a combined approach of histology and cytogenetics correlated well with biologic behavior/disease recurrence. This combined approach is advocated to better stratify patients for treatment purposes and follow‐up. Cancer 2005. © 2004 American Cancer Society.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Deep‐seated, well differentiated lipomatous tumors of the chest wall and extremities

Bassett

Schuetze

Distèche

et al. 2005

Cancer

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“…Pleomorphic liposarcoma is the rarest type of liposarcoma, accounting for less than 5% of cases (27). It occurs in older adults (peak incidence in the 7th decade), with a male predominance (28).…”

Section: Most Common Sarcomas Of the Abdomen And Pelvis Liposarcomamentioning

confidence: 99%

Soft-Tissue Sarcomas of the Abdomen and Pelvis: Radiologic-Pathologic Features, Part 1—Common Sarcomas:From the Radiologic Pathology Archives

et al. 2017

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“…8,9 They represent a relatively well-differentiated liposarcoma, while a minority of retroperitoneal liposarcomas are DLs. [3][4][5][6][7] Morphologically, the clinical behavior of this histologic subtype of liposarcoma is expected to be more aggressive, which has been well documented.…”

Section: Discussionmentioning

confidence: 99%

Retroperitoneal Liposarcoma With Leiomyosarcomatous Differentiation

Suzuki

Fukuchi

Sakurai

et al. 2014

International Surgery

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We herein describe a 60-year-old Japanese man with a giant retroperitoneal liposarcoma undergoing leiomyosarcomatous differentiation. He was admitted to our hospital because of a 5-month history of dysphagia and abdominal distention. Abdominal computed tomography showed a giant tumor that occupied the entire retroperitoneal space. The majority of the mass was lipomatous and low density; both a heterogenous and solid mass were also present. A giant retroperitoneal liposarcoma was diagnosed, and tumor resection was performed. At surgery, the tumor was mostly isolated from the retroperitoneum and other organs. Histopathologically, the tumor comprised welldifferentiated and dedifferentiated liposarcoma with heterologous differentiation of the leiomyosarcomatous components, which is a rare phenomenon in liposarcoma. The patient was alive 3 years after the first treatment, although he has had 3 local recurrences (approximately one recurrence yearly) and has been treated by repeated resection and radiotherapy.

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Atypical and Malignant Neoplasms Showing Lipomatous Differentiation

Cited by 175 publications

References 0 publications

Deep‐seated, well differentiated lipomatous tumors of the chest wall and extremities

Deep‐seated, well differentiated lipomatous tumors of the chest wall and extremities

Soft-Tissue Sarcomas of the Abdomen and Pelvis: Radiologic-Pathologic Features, Part 1—Common Sarcomas:From the Radiologic Pathology Archives

Retroperitoneal Liposarcoma With Leiomyosarcomatous Differentiation

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