Soft-Tissue Sarcomas of the Abdomen and Pelvis: Radiologic-Pathologic Features, Part 1—Common Sarcomas:<i>From the Radiologic Pathology Archives</i>

Levy, Angela D.; Manning, Maria A.; Al‐Refaie, Waddah B.; Miettinen, Markku

doi:10.1148/rg.2017160157

Cited by 77 publications

(70 citation statements)

References 52 publications

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“…When present, imaging findings of a fatty component could be helpful in diagnosis of a liposarcoma. Although rare, osseous differentiation in soft tissue sarcomas and colorectal carcinomas have been reported [6–8]. In the current case, histologic findings and immunohistochemical studies excluded carcinoma, leiomyosarcoma, gastrointestinal stromal tumor, and nerve sheath tumors.…”

Section: Discussionmentioning

confidence: 59%

Osteosarcomatous Divergence in Dedifferentiated Liposarcoma Presenting as a Colonic Mass

Gordhandas

Lin

Tipps

et al. 2019

Case Reports in Pathology

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Dedifferentiated liposarcomas most commonly arise in the retroperitoneum, accounting for 10% of liposarcomas. Heterologous differentiation occurs in 5-10% of dedifferentiated liposarcomas; however, divergent osteosarcomatous differentiation is rare. We report a rare case of initial presentation of dedifferentiated liposarcoma with osteosarcomatous component as a colonic mass in a 72-year-old man. The tumor is mainly composed of bony trabeculae with intervening highly atypical cells and adjacent high-grade mesenchymal nonlipogenic tumor, as well as areas of well-differentiated liposarcoma. Immunohistochemical studies showed diffuse positivity for SATB2 in the atypical cells and fluorescence in situ hybridization revealed high-level amplification of MDM2 gene, supporting the diagnosis of well-differentiated and dedifferentiated liposarcoma with heterologous osteosarcomatous differentiation.

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Section: Discussionmentioning

confidence: 59%

Osteosarcomatous Divergence in Dedifferentiated Liposarcoma Presenting as a Colonic Mass

Gordhandas

Lin

Tipps

et al. 2019

Case Reports in Pathology

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“…Small GISTs form intramural or serosal nodules and, as they grow and expand, may develop intraluminal, intramural, and extraluminal components to varying degrees. The extraluminal component of a malignant GIST may be so large that it is difficult to determine the site of origin [24,25].…”

Section: Discussionmentioning

confidence: 99%

A Huge Pelvic-Abdominal Malignant GIST Tumour in a Patient with Neurofibromatosis Type 1: Case Report and Literature Review

Omar

Alsaati

Waris

2020

Case Reports in Oncological Medicine

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Gastrointestinal stromal tumours are rare tumours of the gastrointestinal tract (GIT) accounting for 0.1%–3% of all gastrointestinal tumours. The most common location is the stomach (55%) followed by the small bowel (31.8%), colon (6%), other various locations (5.5%), and the oesophagus (0.7%). They may also occur in extraintestinal locations. The signs and symptoms of GIST depend on the tumour’s location and size. Gastrointestinal bleeding is one of the most common symptoms. Other signs and symptoms include abdominal discomfort, pain or distention; intestinal obstruction, and weight loss. The association between the development of GISTs and neurofibromatosis 1 (NF1) has been established. NF1-associated GISTs tend to have a distinct phenotype, and the absence of KIT/PDGRFα mutations in turn has implications on further management when they do not respond well to imatinib treatment. Here, we present one of the largest GISTs reported in the literature with a total volume of 25.3×20×14 cm+27.9×23×8 cm and an overall weight of 7.3 kg, which developed in a 43-year-old female patient with NF1 and was resected on an emergency basis due to the rapid deterioration and development of abdominal compartment syndrome. Pathology assessment showed a malignant GIST composed of spindle cells with elongated nuclei with necrosis, marked pleomorphism and numerous giant cell. The mitotic count was >15/50 HPF, Ki 67 was 80%, and the lymphovascular invasion was clear. Immunohistochemistry investigations showed that Vimentin, CD117, and DOG1 were positive, while BCL-2 and CD99 were focal positives. Pan-CK, S-100, CD34, Desmin, SMA, and HMB-45 were negatives.

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“…Die häufigsten intraabdominellen Subtypen stellen das Liposarkom und das Leiomyaosarkom mit Bevorzugung des Retroperitoneums dar. Gastrointestinale Stromatumoren sind die häufigsten intraperitoneal und größtenteils in viszeraler Lokalisation gelegenen mesenchymalen Neoplasien [12]. Weniger häufig, jedoch nicht weniger differenzialdiagnostisch interessant finden sich Entitäten wie das peritoneale Mesotheliom oder Primäre pleomorphe und myxoide Liposarkome finden sich fast ausschließlich an den Extremitäten und stellen im Retroperitoneum eine Rarität dar [12].…”

Section: Hintergrundunclassified

“…Obwohl keine eindeutigen CT-und MRT-spezifischen Charakteristika, bestehen kann der fehlende Fettgehalt als diagnostisches Merkmal herangezogen werden [12].…”

Section: Leiomyosarkomunclassified

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Borderline- und maligne mesenchymale Tumoren des Abdomens

Berzaczy

2017

Radiologe

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Soft-Tissue Sarcomas of the Abdomen and Pelvis: Radiologic-Pathologic Features, Part 1—Common Sarcomas:From the Radiologic Pathology Archives

Cited by 77 publications

References 52 publications

Osteosarcomatous Divergence in Dedifferentiated Liposarcoma Presenting as a Colonic Mass

Osteosarcomatous Divergence in Dedifferentiated Liposarcoma Presenting as a Colonic Mass

A Huge Pelvic-Abdominal Malignant GIST Tumour in a Patient with Neurofibromatosis Type 1: Case Report and Literature Review

Borderline- und maligne mesenchymale Tumoren des Abdomens

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