Atualização em epilepsia

Costa, Lílian Lúcia de Oliveira; Brandão, Erlayne Camapum; Segundo, Luiz Márcio de Brito Marinho

doi:10.11606/issn.1679-9836.v99i2p170-181

Cited by 6 publications

(3 citation statements)

References 43 publications

(72 reference statements)

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“…As crises epiléticas podem ter origem num ponto de um ou ambos os hemisférios cerebrais, sendo denominadas de crises parciais, ou originar-se em uma parte que abrange os dois hemisférios do cérebro, nomeadas de crises generalizadas. As crises parciais iniciam em um foco com as descargas neuronais excessivas e podem partir para ambos os hemisférios, evoluindo para crises generalizadas (Costa, et al, 2020).…”

Section: Introductionunclassified

“…O tratamento medicamentoso tem por finalidade interromper as crises epiléticas através da administração de fármacos anticonvulsivantes (Belgo et al, 2021). A escolha adequada dessas drogas antiepiléticas é baseada nas informações colhidas sobre o tipo de crise e ou síndrome epilética, idade,tolerabilidade, segurança e eficácia desses medicamentos (Costa, et al, 2020).…”

Section: Introductionunclassified

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A eficácia do canabidiol no tratamento da Epilepsia

Omena

Cavalcante

Gusmão

et al. 2022

RSD

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1 Graduação em Farmácia. Centro Universitário Fametro. Manaus, Brasil. 2 Professora Orientadora do Curso de Bacharelado em Farmácia. Centro Universitário Fametro. Manaus, Brasil. Introdução: Epilepsia é uma disfunção cerebral caracterizada pela ocorrência periódica e imprevisível de crises convulsivas, as quais são modificações temporárias do comportamento causadas pela atividade neuronal anormal, desordenada, sincrônica e rítmica. O Canabidiol atua de forma anticonvulsivante através de três mecanismos: neuro protetores, modulação do estresse, ou ainda do balanço excitação/inibição neuronal. Objetivo: Descrever aspectos relacionados ao tratamento da epilepsia com o Canabidiol e derivados. Metodologia: Revisão sistemática seguindo as orientações descritas no método PRISMA. Foi realizada uma busca nas seguintes bases de dados: PUBMED, BVS E SciELO utilizando como descritores os termos: “canabidiol”, “CNB”, “epilepsia”, “epilepsy” e “cannabidiol, os quais foram combinados entre si com o conector “and”. Foram incluídos os estudos primários, na íntegra, publicados durante o período de 2012 a 2022, em português ou inglês, os quais abordaram a temática referente ao uso isolado do Canabidiol no tratamento da Epilepsia. Resultados: 12 artigos foram incluídos para compor esta revisão sistemática, os quais demonstraram uma redução clinicamente significativa nas crises convulsivas mediante o tratamento com o canabidiol. A maioria dos estudos abordou a Lennox-Gastaut ou a síndrome de Dravet, enquanto outros ensaios abordaram epilepsias resistentes ao tratamento de diferentes diagnósticos. A dose mais utilizada foi 20 mg/kg/dia e 10 mg/kg/dia. Conclusão: O canabidiol é eficaz na redução e controle das crises convulsivas de diferentes patologias. É seguro e eficaz para uso adulto e pediátrico. Produz efeito tanto em doses mais altas (20mg/kg/dia) quanto em doses baixas (10mg/kg/dia).

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Section: Introductionunclassified

A eficácia do canabidiol no tratamento da Epilepsia

Omena

Cavalcante

Gusmão

et al. 2022

RSD

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“…Currently, the treatment objective is, in the case of acute seizures, to treat the triggering cause of the seizure, such as fever and infections, reducing the risk of neurological damage. In contrast, chronic seizures treatment aims to provide a good quality of life using antiepileptic drugs [3].…”

Section: Introductionmentioning

confidence: 99%

Concepts, Beliefs, and Traditional Treatment for Childhood Seizures in a Quilombola Community in Northeastern Brazil: Analysis by the Discourse of the Collective Speech

Beltrão

Carneiro

Delmondes

et al. 2021

IJERPH

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Background: Non-pharmacological therapy related to traditional, magical, and/or religious treatments for managing recurrent and non-recurrent seizures in children persists in several traditional communities. The research aims to investigate the concepts, beliefs, and types of traditional treatments used for cases of seizures in children reported by residents of a quilombola community. Methods: The research took place in the quilombo community Sítio Arruda, Ceará, northeastern Brazil. The study population consisted of 19 participants, including healers, prayers, and midwives. Applied a socioeconomic form and a semi-structured interview script. For data analysis, the Discourse of the Collective Speech (DCS) technique was used. Results: For the questions asked, a total of 14 central ideas were found. The most prevalent was seizure is the most common type of disease in children (50.0%); The seizure occurs because of the fever (42.0%); In the community, we treat and prevent seizures with the use of plants (63.2%). Conclusions: The present study’s results addressed relevant issues that include valuing and understanding the traditional knowledge of the community, access to health services, and the need for clarification actions about seizures.

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Judicialización sanitaria y acción de la Defensoría Pública en un caso de insumo no incorporado: la demanda de Cannabidiol en la Defensoría Pública Federal de Salvador/Ba em la última década

Villas-Bôas

2024

Cad. Ibero Am. Direito Sanit.

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Objective: To evaluate the performance of the Federal Public Defender's Office and the effectiveness of the juridification of health, as an instrument to guarantee access to the right, in the case of a non-standardized input (Cannabidiol), in the Salvador/Bahia unit. Methodology: a descriptive study with application of retrospective longitudinal method was carried out on the number of Cannabidiol claims that have reached the unit since the index case admitted in Brazil in 2014, its annual evolution and destination in the institution and in the court, until 2023. Results and discussion: there was a systematic growth in the number of cases, which doubled annually, especially from 2018 onwards, except in 2021. The percentage of judicialized lawsuits was about 59%, and, among those, more than half obtained a favorable decision in some instance, reaching 76% from the merit sentences. The time between the arrival of the applicant, the gathering of documents and the filing of the action was, on average, 2.4 months, and the average interval between the filing of the initial petition and the intimation of the anticipation decision, in the cases where it was granted, was 2 months. On the other hand, the interval between the intimation of the anticipatory decision and the effective compliance oscillated around 9.2 months, only being obtained through judicial blocking in almost 70% of the cases. Conclusion: it was found that the defense was swift, as soon as the necessary documents were gathered, as well as the injunctions granted. On the other hand, the time of compliance after the concession decision showed an alarmingly long interval, resulting in a new form of ineffectiveness of the social right to health, which the judicialization aimed precisely to combat. Submission: 11/30/23| Review: 01/29/24| Approval: 01/30/24

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Atualização em epilepsia

Cited by 6 publications

References 43 publications

A eficácia do canabidiol no tratamento da Epilepsia

A eficácia do canabidiol no tratamento da Epilepsia

Concepts, Beliefs, and Traditional Treatment for Childhood Seizures in a Quilombola Community in Northeastern Brazil: Analysis by the Discourse of the Collective Speech

Judicialización sanitaria y acción de la Defensoría Pública en un caso de insumo no incorporado: la demanda de Cannabidiol en la Defensoría Pública Federal de Salvador/Ba em la última década

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