Attrition of T Cell Memory

Selin, Liisa K.; Lin, Meei-Yun; Kraemer, Kristy A.; Pardoll, Drew M.; Schneck, Jonathan P.; Varga, Steven M.; Santolucito, Paul A.; Pinto, Amelia K.; Welsh, Raymond M.

doi:10.1016/s1074-7613(00)80147-8

Cited by 254 publications

(63 citation statements)

References 35 publications

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“…Mice infected with EV 71 failed to produce type I IFN in response to either poly(I:C) injection or CVB3 infection, both of which are strong inducers of type I IFN [14]. Type I IFNs are produced early in viral infection and are one factor involved in the redistribution of lymphocytes from the peripheral blood into infected tissues [15,16]. …”

Section: Picornaviruses Suppress the Innate Immune Responsementioning

confidence: 99%

Picornavirus Infection Leading to Immunosuppression

2014

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Viruses, such as HIV, hepatitis A, poliovirus, coxsackievirus B3 and foot-and-mouth disease virus, use a variety of mechanisms to suppress the human immune system in order to evade clearance by the host. Therefore, investigating how a few changes in the viral genome of a nonlethal virus can lead to an alteration in disease, from survivable to immunosuppression and death, would provide valuable information into viral pathogenesis. In addition, we propose that gaining a better insight into how these viruses suppress an antiviral immune response could lead to viral-based therapeutics to combat specifc autoimmune diseases such as multiple sclerosis and Type 1 diabetes.

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Section: Picornaviruses Suppress the Innate Immune Responsementioning

confidence: 99%

Picornavirus Infection Leading to Immunosuppression

2014

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“…Supporting the proposition that there are constraints on the number memory T cells in an animal, it has been shown that the size of the pool of LCMV-specific CD8 memory T cells declines when a mouse subsequently develops immunity to other viruses [111, 112]. Although others have reported long-term maintenance of cell numbers in the CD8 memory pool [15, 20, 31], these latter experiments are presumed to have been conducted in the absence of subsequent infections and hence the size of the memory T cell pool in the animals used may be small enough to avoid size constraints.…”

Section: Maintenance Of Memory Cellsmentioning

confidence: 99%

Homeostasis of the Memory T Cell Pool

Marsden

Kappler

Marrack

2006

Int Arch Allergy Immunol

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Memory T cells are critical for the establishment of long-term immunity. The number of memory T cells formed at the conclusion of the primary response is strongly influenced by the number of effector T cells generated in the response, but some factors can additionally enhance the efficiency and quality of memory cell recruitment. Homeostasis of the memory T cell pool depends on cytokine-mediated regulation of cell survival and proliferation. This review discusses factors that influence both the development and the maintenance of the memory T cell pool.

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“…This slow division allows memory CD8ϩ T cells to maintain their numbers despite slow attrition due to cell death. The requirement for IL-15 may be one of the characteristics of CD8ϩ memory T cells, amongst others, which controls their numbers (10,11).…”

mentioning

confidence: 99%