Attributes of Polygonum multiflorum to transfigure red biotechnology

Ho, Thanh-Tam; Murthy, Hosakatte Niranjana; Dalawai, Dayanand; Bhat, Medha A.; Paek, Kee-Yoeup; Park, Soyoung

doi:10.1007/s00253-019-09709-y

Cited by 19 publications

(11 citation statements)

References 44 publications

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“…Then, concentration and exposure time of MJ were determined in the third step, thereafter, scale-up of culture process could be achieved up to pilot-scale. HPLC and Fourier-transform infrared spectroscopy (FT-IR) analysis were applied to investigate the quality of bioactive compounds in the culture [15][16][17]. In this review, the role of MJ on the induction of oxidative stress, antioxidant enzyme activity, signal molecules transduction, and secondary metabolite accumulation in plant cell and organ culture system are introduced and discussed.…”

Section: Introductionmentioning

confidence: 99%

Methyl Jasmonate Induced Oxidative Stress and Accumulation of Secondary Metabolites in Plant Cell and Organ Cultures

Murthy

Park

2020

IJMS

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166

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Recently, plant secondary metabolites are considered as important sources of pharmaceuticals, food additives, flavours, cosmetics, and other industrial products. The accumulation of secondary metabolites in plant cell and organ cultures often occurs when cultures are subjected to varied kinds of stresses including elicitors or signal molecules. Application of exogenous jasmonic acid (JA) and methyl jasmonate (MJ) is responsible for the induction of reactive oxygen species (ROS) and subsequent defence mechanisms in cultured cells and organs. It is also responsible for the induction of signal transduction, the expression of many defence genes followed by the accumulation of secondary metabolites. In this review, the application of exogenous MJ elicitation strategies on the induction of defence mechanism and secondary metabolite accumulation in cell and organ cultures is introduced and discussed. The information presented here is useful for efficient large-scale production of plant secondary metabolites by the plant cell and organ cultures.

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Section: Introductionmentioning

confidence: 99%

Methyl Jasmonate Induced Oxidative Stress and Accumulation of Secondary Metabolites in Plant Cell and Organ Cultures

Murthy

Park

2020

IJMS

Self Cite

166

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“…PMR can moisten intestines and help defecate, remove toxicity, and eliminate carbuncles, while PMRP which is steamed with black soya beans has a large effect including nourishing the liver and kidney, strengthening bones and muscles, and blackening the beard and hair. Modern studies have shown that PMR and PMRP had therapeutic potential for aging, hair loss, hyperlipidemia, inflammation, and cancer [148]. Numerous experimental data indicated the potential of PMR in the treatment of NAFLD.…”

Section: Discussionmentioning

confidence: 99%

A Candidate Drug for Nonalcoholic Fatty Liver Disease: A Review of Pharmacological Activities of Polygoni Multiflori Radix

Zhou

Liu

et al. 2020

BioMed Research International

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Nonalcoholic fatty liver disease, a type of metabolic syndrome, continues to rise globally. Currently, there is no approved drug for its treatment. Improving lifestyle and exercise can alleviate symptoms, but patients’ compliance is poor. More and more studies have shown the potential of Polygoni Multiflori Radix (PMR) in the treatment of NAFLD and metabolic syndrome. Therefore, this paper reviews the pharmacological effects of PMR and its main chemical components (tetrahydroxystilbene glucoside, emodin, and resveratrol) on NAFLD. PMR can inhibit the production of fatty acids and promote the decomposition of triglycerides, reduce inflammation, and inhibit the occurrence of liver fibrosis. At the same time, it maintains an oxidation equilibrium status in the body, to achieve the therapeutic purpose of NAFLD and metabolic syndrome. Although more standardized studies and clinical trials are needed to confirm its efficacy, PMR may be a potential drug for the treatment of NAFLD and its complications. However, the occurrence of adverse reactions of PMR has affected its extensive clinical application. Therefore, it is necessary to further study its toxicity mechanism, enhance efficacy and control toxicity, and even reduce toxicity, which will contribute to the safe clinical use of PMR.

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“…Ho et al (2019) reported [38] that P. multiflorum [Figure 4] is rich in naturally occurring flavonoids, stilbenes, alkaloids, and quinones and is a natural hepato-and nephronprotectant, immunomodulator, as well as exhibits diverse anti-aging/longevity promoting benefits including antialopecia, anti-cancer, antioxidant, anti-bacterial, antihyperlipidemia, and anti-atherosclerosis activities. [38,39] Furthermore, Fo-Ti promotes rejuvenating effects on the nerves, brain cells, and endocrine glands. [40] It supports and promotes competent adrenal function and helps detoxify the body.…”

Section: Water-extract Of Polygonum Multiflorum (Family Asparagaceae) Commonly Known As Fo-ti Root Extractmentioning

confidence: 99%

Design of a Novel Bioflavonoid and Phytonutrient Enriched Formulation in Boosting Immune Competence and Sports Performance: A product Development Investigation

Downs¹,

Banik²,

Bagchi

et al. 2021

AJBPS

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An increase in anaerobic (oxygen-deprived) pathogenesis significantly increases the generation of reactive oxygen species (ROS) inflicting damage on cell membranes and intracellular constituents. Generation of ROS and concomitant inflammatory response is the two hallmarks of cellular damage caused by cellular injury or invasion by pathogens. Oxygen deprivation, as opposed to oxygen deficiency, is a major contributor to oxidative stress and damage, cytokine production, and inflammation. When our cells are unable to efficiently and effectively utilize the oxygen to facilitate aerobic glycolysis and other cellular metabolic events, the oxygen instead oxidizes cell membranes, lipids, neurons, cross-links proteins, damages DNA, and initiates inflammation among other consequences. These anaerobic events are hallmarks of chronic degenerative diseases (CDD). Excessive demands to curtail oxidative damage can overburden endogenous antioxidative capabilities. A key treatment strategy to tackle the adverse effects of inflammation involves the augmentation of the structural integrity and functional competence of cellular materials, reducing the impact and consequences of tissue insult; the generation of ROS; and the cascade of subsequent pathological disorders. Moreover, restoration of cellular aerobic metabolic events, such as aerobic glycolysis and oxidative respiration, is an equally important collateral goal. A healthy diet and supplementation, providing an abundance of exogenous sources of antioxidants and a host of phytochemical dietary components, becomes even more important to restore aerobic metabolism; augment and assist in improving cellular structural integrity, and thereby reducing oxidative stress, damage, and inflammatory sequela. VMP35 MNC, a research-affirmed Prodosomed nutraceutical technology-based phytonutrient formulation, enriched in structurally diverse bioflavonoids, polyphenols, and phenolic saccharides, etc., have been shown to boost cellular structural integrity and physiological functions, and restore aerobic metabolic competence including for athletic performance as well as for general well-being. This review provides a strategic approach for the design of a novel Prodosomed VMP35 Multinutrient/phytoceutical complex and to evaluate its ability to reverse anaerobic pathologies, including inflammation, and restore healthy cellular aerobic glycolysis.

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Attributes of Polygonum multiflorum to transfigure red biotechnology

Cited by 19 publications

References 44 publications

Methyl Jasmonate Induced Oxidative Stress and Accumulation of Secondary Metabolites in Plant Cell and Organ Cultures

Methyl Jasmonate Induced Oxidative Stress and Accumulation of Secondary Metabolites in Plant Cell and Organ Cultures

A Candidate Drug for Nonalcoholic Fatty Liver Disease: A Review of Pharmacological Activities of Polygoni Multiflori Radix

Design of a Novel Bioflavonoid and Phytonutrient Enriched Formulation in Boosting Immune Competence and Sports Performance: A product Development Investigation

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