“…More than one‐third of articles (40%) discussed the impact of treatment cost from a health system perspective, including access to reimbursement. 46 , 48 , 49 , 50 , 51 , 53 , 54 , 56 , 59 , 63 , 66 , 68 , 74 , 75 , 76 , 77 , 81 , 87 , 89 , 91 , 92 , 94 , 100 , 101 , 103 , 106 , 112 , 114 , 115 , 116 , 117 These factors include cost and affordability of treatment, 68 , 87 , 103 , 114 , 118 insurance access, 50 , 59 , 66 , 94 , 115 and a clinic's goal to achieve the best clinical response at the lowest cost. 50 , 91 …”