Attenuation of type 2 diabetes mellitus in the male Zucker diabetic fatty rat: the effects of stress and non-volitional exercise

Király, Michael A.; Bates, Holly E.; Yue, Jessica T.Y.; Goche-Montes, Danitza; Fediuc, Sergiu; Park, Edward; Matthews, Stephen G.; Vranić, Mladen; Riddell, Michael C.

doi:10.1016/j.metabol.2006.12.022

Cited by 70 publications

(83 citation statements)

References 57 publications

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“…32 Kiraly et al (2007) demonstrated that swimming exercise in type 2 diabetic rats elevates β-cell mass by increasing the number of β-cells per. 19 In the present study, β-cell apoptosis through measuring of p53 levels in pancreas tissue of type 2 diabetic rats were decreased by voluntary running. The effects of voluntary exercise on p53 expression level possibility due to the decreasing effect of voluntary exercise on glucose and HbA1clevel.Previous study proved that subjects undergoing exercise training improved many of the abnormalities associated with the type 2 diabetes specially improvement of glycemia control.…”

Section: Discussionsupporting

confidence: 44%

“…18 Kiralyet al exhibited that regular swimming exercise in diabetic rats elevates β-cell mass by increasing the number of β-cells. 19 Comparable results were found by DelghingaroAugusto et al that examined diabetic rats subsequent 6 weeks of voluntary wheel running. 20 Nevertheless, exhaustive exercise may be problematic, as they are stressful through production of reactive oxygen species and can cause damage to muscle tissue and other organs, 21 voluntary exercise may be a better model with more beneficial effects.…”

Section: Introductionmentioning

confidence: 69%

See 1 more Smart Citation

Effect of Crocin and Voluntary Exercise on P53 Protein in Pancreas of Type2 Diabetic Rats

Ghorbanzadeh¹,

Mohammadi²,

Mohaddes³

et al. 2017

Pharm Sci

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Section: Discussionsupporting

confidence: 44%

Section: Introductionmentioning

confidence: 69%

Effect of Crocin and Voluntary Exercise on P53 Protein in Pancreas of Type2 Diabetic Rats

Ghorbanzadeh¹,

Mohammadi²,

Mohaddes³

et al. 2017

Pharm Sci

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“…In rodents, the effect of exercise on diurnal HPA activity and adrenal sensitivity to ACTH is also unclear. For example, compared with S animals, trained animals have increased resting stress hormones (17,25), while others show similar resting concentrations (14,27) or even decreased resting concentrations (4,7,9,19). It is likely that the variety of training protocols and the varying training durations used, as well as the timing of blood sampling in these rodent studies, contributes to the discrepancies in findings.…”

Section: Discussionmentioning

confidence: 97%

Voluntary wheel running initially increases adrenal sensitivity to adrenocorticotrophic hormone, which is attenuated with long-term training

Campbell

Rakhshani²,

Fediuc³

et al. 2009

Journal of Applied Physiology

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Campbell JE, Rakhshani N, Fediuc S, Bruni S, Riddell MC. Voluntary wheel running initially increases adrenal sensitivity to adrenocorticotrophic hormone, which is attenuated with long-term training. J Appl Physiol 106: 66 -72, 2009. First published November 13, 2008 doi:10.1152/japplphysiol.91128.2008.-Although exercise is a common and potent activator of the hypothalamic-pituitary adrenal (HPA) axis, the effects of exercise on the acute stress response are not well understood. Here, we investigated the effects of short-(2 wk) and long-term (8 wk) voluntary wheel running on adrenal sensitivity to ACTH stimulation and the acute stress response to restraint in male rats. Diurnal glucocorticoid patterns were measured on days 7 (all groups) and 35 (8-wk groups). Rats were subjected to 20 min of restraint stress on either week 1 or on week 7 of treatment to assess HPA activation. One week later, exogenous ACTH (75 ng/kg) was administered to assess adrenal sensitivity to ACTH. Following this, adrenals were collected and analyzed for key proteins involved in corticosterone (CORT) synthesis. By the end of week 1, exercising (E) animals had twofold higher peak diurnal CORT levels compared with sedentary (S) animals (P Ͻ 0.01). CORT values were not different between groups at week 8. In response to restraint stress at week 2, CORT values in E were approximately threefold greater than in S (P Ͻ 0.05). No difference was found between E and S rats in the response to, or recovery from, restraint at week 8. During the ACTH challenge at week 2, E demonstrated a ϳ2.5-fold increase in adrenal sensitivity compared with S, while no difference was found between E and S at week 8. The expression of steroidogenic acute regulatory protein was found to be ϳ50% higher in the adrenals in E compared with S at week 2 (P Ͻ 0.05), but no difference existed between groups at week 8. These results show that volitional wheel running initially causes hyperactivation of the HPA axis, due to enhanced adrenal sensitivity to ACTH, but that these alterations in HPA activity are completely restored by 8 wk of training. glucocorticoids; corticosterone; adrenocorticotropic hormone; voluntary exercise; circadian rhythm; restraint stress; adrenocorticotropic hormone challenge; glucocorticoid receptor THE HYPOTHALAMIC-pituitary-adrenal (HPA) axis is a vital component of the body's stress response system. This pathway is activated by a variety of stressors that increase the pituitary release of adrenocorticotropic hormone (ACTH) into the circulation. ACTH stimulates the adrenal release of glucocorticoids (GCs), which, in turn, mobilize energy sources for the increased metabolic demands placed on the body. Acutely, this recruitment of energy sources is essential for events, such as physical exercise; however, restoration of the axis is imperative to prevent overexposure to GCs. It has been well established that chronically elevated levels of plasma GCs can lead to the development of a number of harmful pathologies, including impaired insulin signaling, centr...

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“…The uptake of glucose into muscle is high even after exercise, because the routes which stimulate glucose uptake remain active for hours after exercise (33,34). Due to increased GLUT4 protein, increased displacement, and increased exposure of these transport proteins at the cell surface, the muscle contraction increases membrane permeability to glucose and improves insulin action in glucose metabolism (35). The increased insulin sensitivity after exercise occurs simultaneously with the accumulation of muscle glycogen stores (11).…”

Section: Discussionmentioning

confidence: 99%

The comparison of continuous and intermittent training impact on glucose-4 transporter protein level and insulin sensitivity in diabetic rats

Esmaiel

Reza

Hossein

et al. 2016

JBRMS

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Introduction: Diabetes mellitus (DM) is now seen as a worldwide epidemic disease with high prevalence. Exercise training (ET) is known to promote beneficial changes in diabetic patients. The aim of this study was to compare the impact of continuous and intermittent aerobic training on glucose-4 transporter protein (GLUT-4) levels and insulin sensitivity in diabetic rats. Materials and methods:This research was an experimental and interventional study. A number of 60 male rats weighing 180 to 310 grams and 13 weeks old were divided into six groups: healthy control, healthy continuous, healthy intermittent, diabetic control, diabetic continuous, and diabetic intermittent groups. The exercise protocol in both continuous and intermittent groups was aerobic training for six weeks which was conducted considering overload principle. The data were analyzed using one-way analysis of variance test in P< 0.05 level. Results:The results showed that despite the significant difference between insulin resistance and GLUT4 level among diabetic rats in different groups compared to control group, there was no significant difference between the impact of continuous and intermittent training on these indices (P=1.00). Conclusion: Through increasing the GLUT4 protein content, the continuous and intermittent training improved insulin resistance.

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Attenuation of type 2 diabetes mellitus in the male Zucker diabetic fatty rat: the effects of stress and non-volitional exercise

Cited by 70 publications

References 57 publications

Effect of Crocin and Voluntary Exercise on P53 Protein in Pancreas of Type2 Diabetic Rats

Effect of Crocin and Voluntary Exercise on P53 Protein in Pancreas of Type2 Diabetic Rats

Voluntary wheel running initially increases adrenal sensitivity to adrenocorticotrophic hormone, which is attenuated with long-term training

The comparison of continuous and intermittent training impact on glucose-4 transporter protein level and insulin sensitivity in diabetic rats

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