Attenuation of the reflex responses to muscle contraction by the coadministration of antagonists to substance P and somatostatin into the dorsal horn

Wilson, LB; Pt, Wall; Matsukawa, Kanji

doi:10.1016/s0008-6363(96)88595-6

Cited by 6 publications

(1 citation statement)

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“…Thus, even though poorly understood, the possibility of pain induced muscle ischemia must be kept in mind. Furthermore, nociceptive pain (Lindh et al, 1997) and static contractions (Wilson et al, 1993) cause a release of substance P (SP) in the cerebrospinal fluid (CSF) and SP plays a role in the mediation of cardiovascular and MSNA responses during static exercise (Wilson et al, 1995). The highly elevated concentrations of SP in the CSF of FM patients (Vaeroy et al, 1988;Russell et al, 1994) could interfere with normal regulatory mechanisms during exercise.…”

Section: Pain Related Muscle Ischemiamentioning

confidence: 99%

Decreased muscle blood flow in fibromyalgia patients during standardised muscle exercise: A contrast media enhanced colour doppler study

Elvin

Siösteen

Nilsson

et al. 2006

European Journal of Pain

138

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The aim of the study was to investigate if contrast enhanced ultrasound (US) imaging of muscular blood flow during and following exercise could detect alterations in vascularity in fibromyalgia (FM) patients. Ten FM patients and 10 matched controls were examined with US during standardised static and directly following static and dynamic muscular contractions of the infraspinatus muscle. Doppler ultrasound evaluation was performed before and after the administration of ultrasound contrast media. The FM patients had lower magnitude of muscle vascularity following dynamic (p<0.001) and during (p<0.002) static exercise compared to controls. The immediate flow response to muscular activity was not only of a lower magnitude, but also of a shorter duration in FM patients following dynamic exercise (p<0.001) and during static exercise (p<0.01). There were no statistically significant group differences in blood flow intensity or duration following static contraction. In conclusion, contrast enhanced US was found useful to study real-time muscle blood flow changes during and following standardised, low-intensity exercise in FM patients and healthy controls. Our results support the suggestion that muscle ischemia can contribute to pain in FM, possibly by maintaining the central nervous changes such as central sensitisation/disinhibition. US with contrast can be a new valuable approach to assess muscle perfusion in pain patients during standardised exercise.

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Section: Pain Related Muscle Ischemiamentioning

confidence: 99%

Decreased muscle blood flow in fibromyalgia patients during standardised muscle exercise: A contrast media enhanced colour doppler study

Elvin

Siösteen

Nilsson

et al. 2006

European Journal of Pain

138

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The epidural and intrathecal administration of somatotrophin-release inhibiting factor: Native and synthetic analogues

Beltrutti¹,

Moessinger²,

Varrassi

2000

Current Review of Pain

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It is well-known that morphine is the king of analgesics. It is widely used, and administered in various ways for the control of acute and chronic pain states. There are, however, certain types of pain and certain clinical conditions in which morphine cannot be used due to the risk of possible complications. These are usually pain states associated with intracranial hypertension, the presence of serious respiratory problems, the onset of major opioid tolerance, persistent vomiting, and so on. The search for "alternative analgesics" has been in progress for a decade, alternatives that could be used alone or in combination for spinal administration in the treatment of complex chronic pain states and with a low incidence of secondary effects. Today, research is carefully assessing the clinical effectiveness and the side effects of a series of drugs for spinal administration, that is, epidural or intrathecal, such as the new narcotics, alpha-2 agonists, central muscle relaxants, calcitonin, and local anesthetics. In this alternative analgesic category we have to mention the somatotrophin-release inhibiting factor (SRIF), which is an ubiquitous native hormone with widespread, predominantly inhibitory actions, and octreotide, its synthetic analogue. In this article we review the literature on the natural drug and its synthetic analogue, paying particular attention to the problems connected with intraspinal administration and analgesic properties.

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Anti-somatostatin antisera, but neither a somatostatin agonist (octreotide) nor antagonist (CYCAM), attenuates hyperalgesia in the rat

Traub

Brozoski

1996

Peptides

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Attenuation of the reflex responses to muscle contraction by the coadministration of antagonists to substance P and somatostatin into the dorsal horn

Cited by 6 publications

References 0 publications

Decreased muscle blood flow in fibromyalgia patients during standardised muscle exercise: A contrast media enhanced colour doppler study

Decreased muscle blood flow in fibromyalgia patients during standardised muscle exercise: A contrast media enhanced colour doppler study

The epidural and intrathecal administration of somatotrophin-release inhibiting factor: Native and synthetic analogues

Anti-somatostatin antisera, but neither a somatostatin agonist (octreotide) nor antagonist (CYCAM), attenuates hyperalgesia in the rat

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