Attenuation of the bidirectional effects of chlordiazepoxide and FG 7142 on conditioned response suppression and associated cardiovascular reactivity by loss of cortical cholinergic inputs

Stowell, Jeffrey R.; Berntson, Gary G.; Sarter, Martin

doi:10.1007/s002130000443

Cited by 21 publications

(26 citation statements)

References 47 publications

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“…The reported deficits support the hypothesis of a role of this neural site in general learning and memory mechanisms (Dunnett et al 1985;Casamenti et al 1988;Aaltonen et al 1991;Schauz and Koch 1999;Gonzalez et al 2000;Stowell et al 2000;Moron et al 2002;Power and McGaugh 2002;Vale-Martinez et al 2002;Conner et al 2003;Frick et al 2004;Knox and Berntson 2006). Nevertheless, it must be underlined that these were permanent lesions.…”

supporting

confidence: 70%

“…Although many published reports have analyzed NBM involvement in fear conditioning acquisition (Stowell et al 2000;Conner et al 2003;Frick et al 2004;Knox and Berntson 2006), not much is known about the role played by NBM during fear mnemonic processing that takes place between acquisition and retrieval, i.e., during consolidation, when the mnemonic trace changes from shortterm to long-term to be subsequently stored (Frick et al 2004).…”

mentioning

confidence: 99%

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The role of the nucleus basalis magnocellularis in fear conditioning consolidation in the rat

Baldi¹,

Mariottini²,

Bucherelli³

2007

Learn. Mem.

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The nucleus basalis magnocellularis (NBM) is known to be involved in the memorization of several conditioned responses. To investigate the role of the NBM in fear conditioning memorization, this neural site was subjected to fully reversible tetrodotoxin (TTX) inactivation during consolidation in adult male Wistar rats that had undergone fear training to acoustic conditioned stimulus (CS) and context. TTX was stereotaxically administered to different groups of rats at increasing intervals after the acquisition session. Memory was assessed as the conditioned freezing duration measured during retention testing, always performed 72 and 96 h after TTX administration. In this way, there was no interference with normal NBM function during either acquisition or retrieval phases, allowing any amnesic effect to be due only to consolidation disruption. The results show that for contextual fear response memory consolidation, NBM functional integrity is necessary up to 24 h post-acquisition. On the other hand, NBM functional integrity was shown to be necessary for memory consolidation of the acoustic CS fear response only immediately after acquisition and not 24-h post-acquisition. The present findings help to elucidate the role of the NBM in memory consolidation and better define the neural circuits involved in fear memories.

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supporting

confidence: 70%

mentioning

confidence: 99%

The role of the nucleus basalis magnocellularis in fear conditioning consolidation in the rat

Baldi¹,

Mariottini²,

Bucherelli³

2007

Learn. Mem.

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“…However, with this treatment residual cholinergic input to the mPFC remains and cholinergic input to posterior midline cortical systems (e.g. RSC) is unaffected (Knox and Berntson, 2008; Stowell, Berntson, and Sarter, 2000; Torres, Perry, Blockland, Wilkinson, Wiley, Lappi, and Dunnet, 1994). …”

Section: Bf Cholinergic Neurons In Fear and Extinction Memorymentioning

confidence: 99%

“…NBM corticopetal cholinergic lesions attenuate cued and contextual fear conditioned suppression (Knox and Berntson, 2006; 2008; Stowell et al, 2000), though operant performance is not affected, and animals with NBM corticopetal cholinergic lesions can still display operant suppression to footshocks (Knox and Berntson, 2008; McGaughy et al, 1996; Stowell et al, 2000). These findings strongly suggest that NBM corticopetal cholinergic neurons are critical for fear memory.…”

Section: Bf Cholinergic Neurons In Fear and Extinction Memorymentioning

confidence: 99%

The role of basal forebrain cholinergic neurons in fear and extinction memory

Knox

2016

Neurobiology of Learning and Memory

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Cholinergic input to the neocortex, dorsal hippocampus (dHipp), and basolateral amygdala (BLA) is critical for neural function and synaptic plasticity in these brain regions. Synaptic plasticity in the neocortex, dHipp, ventral Hipp (vHipp), and BLA has also been implicated in fear and extinction memory. This finding raises the possibility that basal forebrain (BF) cholinergic neurons, the predominant source of acetylcholine in these brain regions, have an important role in mediating fear and extinction memory. While empirical studies support this hypothesis, there are interesting inconsistencies among these studies that raise questions about how best to define the role of BF cholinergic neurons in fear and extinction memory. Nucleus basalis magnocellularis (NBM) cholinergic neurons that project to the BLA are critical for fear memory and contextual fear extinction memory. NBM cholinergic neurons that project to the neocortex are critical for cued and contextual fear conditioned suppression, but are not critical for fear memory in other behavioral paradigms and in the inhibitory avoidance paradigm may even inhibit contextual fear memory formation. Medial septum and diagonal band of Broca cholinergic neurons are critical for contextual fear memory and acquisition of cued fear extinction. Thus, even though the results of previous studies suggest BF cholinergic neurons modulate fear and extinction memory, inconsistent findings among these studies necessitates more research to better define the neural circuits and molecular processes through which BF cholinergic neurons modulate fear and extinction memory. Furthermore, studies determining if BF cholinergic neurons can be manipulated in such a manner so as to treat excessive fear in anxiety disorders are needed.

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“…Joel and Doljansky 2003;Pitman 1989), but much less is known about neural correlates of operant extinction following positive reinforcement. However, there is evidence for a role for GABAergic processes (which have also been implicated during extinction of Pavlovian conditioned fear responses, see Harris and Westbrook 1998;Shumyatsky et al 2002;Stowell et al 2000). Williams et al (1990) trained rats to lever press for a food reinforcer on a discretetrial fixed-ratio (FR) schedule and followed this with a number of sessions of extinction in which no food was presented.…”

Section: Introductionmentioning

confidence: 99%

Facilitation of extinction of operant behaviour in mice by d-cycloserine

et al. 2008

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Attenuation of the bidirectional effects of chlordiazepoxide and FG 7142 on conditioned response suppression and associated cardiovascular reactivity by loss of cortical cholinergic inputs

Abstract: The behavioral and autonomic responses to anxiety-related stimuli, as well as the modulatory effects of BZR ligands, are mediated in part via cortical cholinergic inputs.

Cited by 21 publications

References 47 publications

The role of the nucleus basalis magnocellularis in fear conditioning consolidation in the rat

The role of the nucleus basalis magnocellularis in fear conditioning consolidation in the rat

The role of basal forebrain cholinergic neurons in fear and extinction memory

Facilitation of extinction of operant behaviour in mice by d-cycloserine

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