Attenuation of subchronic formaldehyde inhalation toxicity with oral administration of glutamate, glycine and methionine

Katsnelson, Boris A.; Degtyareva, Tamara D.; Privalova, Larisa I.; Minigaliyeva, Ilzira A.; Slyshkina, T. V.; Ryzhov, Vladimir V; Beresneva, Olga Yu

doi:10.1016/j.toxlet.2013.04.024

Cited by 22 publications

(11 citation statements)

References 12 publications

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“…1). It is well known that formaldehyde has high acute toxicity, genotoxicity and carcinogenicity that is pre-determined by its high solubility and reactivity in interactions with nucleophilic groups of protein, DNA and RNA molecules (Katsnelson et al, 2013). Although the previous experimental studies did not detect formaldehyde (Wan et al, 2009), further in vivo or in vitro experiments on biotransformation of MeO-PBDEs should try to identify the metabolite.…”

Section: Toxicology Implicationsmentioning

confidence: 99%

Transformation pathways of MeO-PBDEs catalyzed by active center of P450 enzymes: A DFT investigation employing 6-MeO-BDE-47 as a case

et al. 2015

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Section: Toxicology Implicationsmentioning

confidence: 99%

Transformation pathways of MeO-PBDEs catalyzed by active center of P450 enzymes: A DFT investigation employing 6-MeO-BDE-47 as a case

et al. 2015

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“…The absence of FA-derived DNA adducts in the BM is probably a sign that a generation of leukemia by FA is not biologically probable [23,24]. Nevertheless, recently, there have been several researches that have registered significant augments in toxicity, oxidative damage, and DNA damage in the bone marrow of mice exposed to FA [25,26] (Table 2). In human subjects, FA-exposed employees have been described to present augmented occurrences of DNA-protein crosslinks and structural chromosome mutations in lymphocyte [27].…”

Section: Discussionmentioning

confidence: 99%

Formaldehyde Exposure and Acute Myeloid Leukemia: A Review of the Literature

et al. 2019

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Background and objective: The aim of the present study was to evaluate associations between cumulative and peak formaldehyde exposure and occurrence of acute myeloid leukemia. Material and Methods: A comprehensive search was performed using the PubMed and Embase databases. We included studies presenting information about the role of formaldehyde in leukemic occurrence and mortality risk. Then, full texts of the selected references were assessed, and references of included studies were checked to identify additional articles. Result: The information was then summarized and organized in the present review. A total of 81 articles were obtained from the search. Conclusion: Findings from the review of the literature do not support the hypothesis that formaldehyde is a cause of acute myeloid leukemia.

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“…By reducing the toxicity of a substance and its accumulation in target organs and cells by means of bioprotective agents, it proved possible to lower thereby the mutagenic (genotoxic) action as well if it is inherent in this substance. We showed it first for the action of arsenic and its combination with chromium, cadmium and lead [20] [21] and then for the action of formaldehyde [15], benzo(a)pyrene and multicomponent combinations including this PAH and mutagenic metals [21]. Such effect suggests reduced carcinogenicity which is associated for at least some metals which are carcinogenesis initiators (for example, for arsenic and chromium) with their genotoxiicity.…”

Section: Theoretical Premises Of Active Biological Prophylaxis and Exmentioning

confidence: 99%

“…We investigated this particular field for a few decades, first of all, in animal experiments modeling chronic or subchronic exposures to silica [3] [6], asbestos [7], monazite [8], lead [9] [10], fluoride [11], chromium, arsenic, manganese, nickel, vanadium [12], nanosilver [13], nanocopper [14], formaldehyde [15], phenol, naphthalene, benzo(a)pyrene, different combinations of these toxics [9] [10] [12].…”

Section: Introductionmentioning

confidence: 99%

Enhancing Population’s Resistance to Toxic Exposures as an Auxilliary Tool of Decreasing Environmental and Occupational Health Risks (a Self-Overview)

Katsnelson¹,

Privalova²,

Gurvich³

et al. 2014

JEP

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Environment chemical pollution can be persistent, and even virtually irremovable. For some chemicals in the workplace environment reliably safe low exposure levels are technically unattainable or presumably nonexistent. As a supplement to decreasing harmful exposures to as low levels as possible, the "biological prophylaxis" aims at enhancing host's protective mechanisms. During over 30 years in animal experiments modeling isolated or combined chronic or subchronic exposures to silica, asbestos, monazite, lead, chromium, arsenic, manganese, nickel, vanadium, nanosilver, nanocopper, formaldehyde, phenol, naphthalene, benzo(a)pyrene we tested so-called "bioprophylatic complexes" (BPCs) comprising innocuous substances with theoretically expected beneficial influence on the toxicokinetics and/or toxicodynamics of those toxics. The BPCs proved protectively effective in animal experiments were then subjected to controlled field trials on restricted groups of volunteers. Once the effectiveness and safety of a BPC was established, it was recommended for practical use, first of all, in the most vulnerable population groups (children, pregnant women) and in the most harmful occupations. At each stage of this work the effectiveness of the bioprophylactic approach to chemical risks management was successfully demonstrated. The BPCs tested up to now proved capable of mitigating systemic toxicity, cytotoxicity, fibrogenicity, and mutagenicity of the above-listed chemicals. B. A. Katsnelson et al.

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Attenuation of subchronic formaldehyde inhalation toxicity with oral administration of glutamate, glycine and methionine

Cited by 22 publications

References 12 publications

Transformation pathways of MeO-PBDEs catalyzed by active center of P450 enzymes: A DFT investigation employing 6-MeO-BDE-47 as a case

Transformation pathways of MeO-PBDEs catalyzed by active center of P450 enzymes: A DFT investigation employing 6-MeO-BDE-47 as a case

Formaldehyde Exposure and Acute Myeloid Leukemia: A Review of the Literature

Enhancing Population’s Resistance to Toxic Exposures as an Auxilliary Tool of Decreasing Environmental and Occupational Health Risks (a Self-Overview)

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