Enhancing Population’s Resistance to Toxic Exposures as an Auxilliary Tool of Decreasing Environmental and Occupational Health Risks (a Self-Overview)

Abstract

Environment chemical pollution can be persistent, and even virtually irremovable. For some chemicals in the workplace environment reliably safe low exposure levels are technically unattainable or presumably nonexistent. As a supplement to decreasing harmful exposures to as low levels as possible, the "biological prophylaxis" aims at enhancing host's protective mechanisms. During over 30 years in animal experiments modeling isolated or combined chronic or subchronic exposures to silica, asbestos, monazite, lead, chromium, arsenic, manganese, nickel, vanadium, nanosilver, nanocopper, formaldehyde, phenol, naphthalene, benzo(a)pyrene we tested so-called "bioprophylatic complexes" (BPCs) comprising innocuous substances with theoretically expected beneficial influence on the toxicokinetics and/or toxicodynamics of those toxics. The BPCs proved protectively effective in animal experiments were then subjected to controlled field trials on restricted groups of volunteers. Once the effectiveness and safety of a BPC was established, it was recommended for practical use, first of all, in the most vulnerable population groups (children, pregnant women) and in the most harmful occupations. At each stage of this work the effectiveness of the bioprophylactic approach to chemical risks management was successfully demonstrated. The BPCs tested up to now proved capable of mitigating systemic toxicity, cytotoxicity, fibrogenicity, and mutagenicity of the above-listed chemicals. B. A. Katsnelson et al.

Some inferences from in vivo experiments with metal and metal oxide nanoparticles: the pulmonary phagocytosis response, subchronic systemic toxicity and genotoxicity, regulatory proposals, searching for bioprotectors (a self-overview)

“…The general concept of such "biological prophylaxis" of different occupational and environmental intoxications, its theoretical premises and general principles along with numerous examples of their realization have been published by us over several decades repeatedly, including, in review articles. 109,110 Now we began to use this experience for trying to protect the organism against the impacts of nanometals.…”

Looking for Biological Protectors against Adverse Health Effects of Some Nanoparticles that Can Pollute Workplace and Ambient Air (A Summary of Authors’ Experimental Results)

“…Although it has already been discussed by us in this Journal [80], we reckon it useful to be briefly presented here.…”

Is it possible to enhance the organism’s resistance to toxic effects of metallic nanoparticles?

“…Although our studies summarized by Katsnelson et al (2014a) demonstrated a high efficiency of the organism's defenses against such nanoparticles' impact, safe levels of the latter should be very low if possible at all, due to these particles' especially high toxicity and seemingly obligatory genotoxicity. Therefore we deemed worthwhile to try and enhance the natural resistance to their adverse health effects with the help of so called bio-protectors.…”