Attenuation of skeletal muscle atrophy via acupuncture, electro-acupuncture, and electrical stimulation

Symons, T. Brock; Park, Jinho; Kim, Joo Hyun; Kwon, Eun Hye; Delacruz, Jesse; Lee, Junghoon; Park, Yoonjung; Chung, Eunhee; Lee, Sukho

doi:10.1016/j.imr.2023.100949

Cited by 4 publications

(1 citation statement)

References 40 publications

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“…GCM and EDL muscles were homogenized in RIPA buffer containing protease/phosphatase inhibitor cocktails and then centrifuged at 12,000 rpm for 1 h at 4°C ( Brock Symons et al ., 2023 ). Proteins (30 µg) were separated using sodium dodecyl sulfate-polyacrylamide gel electrophoresis to measure their expression.…”

Section: Methodsmentioning

confidence: 99%

Aerobic Exercise Ameliorates Muscle Atrophy Induced by Methylglyoxal via Increasing Gastrocnemius and Extensor Digitorum Longus Muscle Sensitivity

Hong

Lee

Park

et al. 2023

Biomol Ther (Seoul)

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Muscle atrophy is characterized by the loss of muscle function. Many efforts are being made to prevent muscle atrophy, and exercise is an important alternative. Methylglyoxal is a well-known causative agent of metabolic diseases and diabetic complications. This study aimed to evaluate whether methylglyoxal induces muscle atrophy and to evaluate the ameliorative effect of moderate-intensity aerobic exercise in a methylglyoxal-induced muscle atrophy animal model. Each mouse was randomly divided into three groups: control, methylglyoxal-treated, and methylglyoxal-treated within aerobic exercise. In the exercise group, each mouse was trained on a treadmill for 2 weeks. On the last day, all groups were evaluated for several atrophic behaviors and skeletal muscles, including the soleus, plantaris, gastrocnemius, and extensor digitorum longus were analyzed. In the exercise group, muscle mass was restored, causing in attenuation of muscle atrophy. The gastrocnemius and extensor digitorum longus muscles showed improved fiber cross-sectional area and reduced myofibrils. Further, they produced regulated atrophy-related proteins ( i.e. , muscle atrophy F-box, muscle RING-finger protein-1, and myosin heavy chain), indicating that aerobic exercise stimulated their muscle sensitivity to reverse skeletal muscle atrophy. In conclusion, shortness of the gastrocnemius caused by methylglyoxal may induce the dynamic imbalance of skeletal muscle atrophy, thus methylglyoxal may be a key target for treating skeletal muscle atrophy. To this end, aerobic exercise may be a powerful tool for regulating methylglyoxal-induced skeletal muscle atrophy.

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Section: Methodsmentioning

confidence: 99%

Aerobic Exercise Ameliorates Muscle Atrophy Induced by Methylglyoxal via Increasing Gastrocnemius and Extensor Digitorum Longus Muscle Sensitivity

Hong

Lee

Park

et al. 2023

Biomol Ther (Seoul)

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Evidence and acupoint combinations in acupuncture for functional dyspepsia: an overview of systematic review and data mining study

Menglong,

Zhuoyu,

Dan

et al. 2023

Digital Chinese Medicine

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Recent Advance of Triboelectric Nanogenerator-Based Electrical Stimulation in Healthcare

Wang,

Nie

et al. 2023

Electronics

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Along with the continuous aging of the population, various diseases have brought a great threat to human health and a large economic burden. The development of advanced medical devices has gained global attention for disease treatment. Electrical stimulation refers to stimulation and treatment of cells by high output voltage, which is an important rehabilitation and therapeutic strategy in medical treatment. Triboelectric nanogenerators (TENGs), which are lightweight and feature high-voltage output and flexible structure, have drawn great attention in the field of disease treatment for health care. The conversion of the body’s mechanical energy into electrical pulses to stimulate cells for health treatment through TENG has promising applications. Using uniquely designed TENGs to convert human mechanical energy into electrical impulses to stimulate cells is considered a promising health treatment. Here, we review the recent progress of TENG-based electrical stimulation for disease treatments, focusing on the structure, materials, and performances of the TENGs used in diverse facets of healthcare. More importantly, we systematically discuss the application of TENG-based electrical stimulation in wound healing, osteoblast proliferation and differentiation, muscle stimulation, nerve stimulation, and pacemakers. Finally, several developmental challenges of and prospective solutions for TENG-based electrical stimulation are discussed and summarized in light of recent advances.

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Attenuation of skeletal muscle atrophy via acupuncture, electro-acupuncture, and electrical stimulation

Cited by 4 publications

References 40 publications

Aerobic Exercise Ameliorates Muscle Atrophy Induced by Methylglyoxal via Increasing Gastrocnemius and Extensor Digitorum Longus Muscle Sensitivity

Aerobic Exercise Ameliorates Muscle Atrophy Induced by Methylglyoxal via Increasing Gastrocnemius and Extensor Digitorum Longus Muscle Sensitivity

Evidence and acupoint combinations in acupuncture for functional dyspepsia: an overview of systematic review and data mining study

Recent Advance of Triboelectric Nanogenerator-Based Electrical Stimulation in Healthcare

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