Attenuation of DMBA/croton oil induced mouse skin papilloma by<i>Apodytes dimidiata</i>mediated by its antioxidant and antimutagenic potential

Divya, Menon Kunnathully; Salini, Sasidharan; Meera, Nair; Lawrence, Lincy; Menon, Seema; Raghavamenon, Achuthan C.; Babu, T. Ramesh

doi:10.3109/13880209.2015.1107747

Cited by 3 publications

(3 citation statements)

References 35 publications

(33 reference statements)

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“…It is likely that NO scavenging ability of AMF may have a contributory role in nephroprotectivity. In an earlier study, NaF-induced imbalance in redox status was found to be regained by AMF administration in mice (Divya et al 2016). Thus, the nitric oxide and other oxygen free radical scavenging phytoconstituents in AMF might be responsible for the nephroprotective effect.…”

Section: Discussionmentioning

confidence: 99%

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Ameliorative effect ofApodytes dimidiataon cisplatin-induced nephrotoxicity in Wistar rats

Divya

Lawrence

Raghavamenon

et al. 2016

Pharmaceutical Biology

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Context Nutraceuticals possessing antioxidant potential have been used to alleviate side effects exerted by many chemotherapeutics, including cisplatin. Since Apodytes dimidiata E. Mey. Ex Arn. (Icacinaceae) shows antioxidant potential, it may possess significant chemoprotective effects. Objectives The study investigated whether A. dimidiata could attenuate cisplatin-induced renal damage. Materials and methods Nephrotoxicity was induced by cisplatin (single i.p., 16 mg/kg b wt.) in Wistar rats. Methanolic leaf extract of A. dimidiata (AMF) was administered at a dose of 250 mg/kg b. wt. orally for 5 consecutive days before/after cisplatin administration. Blood and renal parameters were analysed. Total phenolic and flavonoid content in AMF and its NO scavenging effect was determined. Results Significant protective effect of AMF on cisplatin-induced nephrotoxicity was observed in pre-treated animals. The reduction of urea, creatinine and lipid peroxidation was 58.31%, 42.19% and 60%, respectively, and the increase in haemoglobin and leucocyte count was 28.25% and 42.91%, respectively. The increase calculated for GSH, GP x, SOD and catalase was 35.64%, 18.14%, 74.42% and 35.46%, respectively. Tissue architecture of kidney was almost normal in AMF treated animals. The results were comparable to the standard drug, silymarin. AMF contained high level of polyphenols and flavonoids and was found to scavenge NO radicals (IC 50 121.8 mg/mL). Discussion and conclusion AMF can effectively counteract cisplatin mediated renal acute toxicity possibly by scavenging reactive oxygen and nitrogen species. Accordingly, the study suggests that AMF can ameliorate free radical-induced damage associated with chemotherapeutic drugs. ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 99%

“…The phytochemical screening of leaf acetone extract showed the presence of saponins, tannins, terpenes, steroids and flavonoids (Masoko & Nxumalo 2013). Moreover, in our previous studies, the antitumour (Divya et al 2015) and chemopreventive (Divya et al 2016) effects of A. dimidiata were revealed.…”

Section: Introductionmentioning

confidence: 99%

Ameliorative effect ofApodytes dimidiataon cisplatin-induced nephrotoxicity in Wistar rats

Divya

Lawrence

Raghavamenon

et al. 2016

Pharmaceutical Biology

Self Cite

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“…The level of lipid peroxidation in the skin tissue was determined by measuring the MDA content using the method described by Divya et al 2016 16. Briefly, 0.2 ml of homogenate was mixed with 0.2 ml of sodium dodecyl sulphate (8.1%), 1.5 ml of acetic acid (pH 3.5, 30%) and 1.5 ml of thiobarbituric acid (0.8%).…”

Section: Methodsmentioning

confidence: 99%

Chemomodulatory Potential of Bartogenic Acid Against DMBA/Croton Oil Induced Two-Step Skin Carcinogenesis in Mice

et al. 2016

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Barringtonia racemosa fruits are believed to be useful in cancer treatment in Ayurveda, the Indian system of medicine. In present study, bartogenic acid (BA), a triterpenoid constituent of Barringtonia fruits was evaluated for its cytotoxicity property using the human skin carcinoma cell line (SCC-13) and human peripheral blood mononuclear cells (PBMC). The chemopreventive efficacy of BA was evaluated against the DMBA/Croton oil-induced skin carcinogenesis in mice.BA was orally administered at the doses of 1, 2 or 4 mg/kg/day or applied topically every day for 12 weeks following DMBA application. The in vitro data from cell lines revealed that BA induces cytotoxicity against the SCC-13 cells (IC50=7.5 µM). It was found 4.05 times more selective to exert cytotoxicity against SCC-13 as compared to the PBMC (IC50=30.4 µM). The in vivo datacollected from mice model of DMBA/Croton oil-induced skin carcinogenesis revealed that BA administered orally or applied topically, both reduced the precancerous skin lesions andthe incidence of tumor bearing. The oral doses of BA (2 and 4 mg/kg) and topical treatment significantly reduced the incidence and number of skin papillomas. At these doses, BA also increased the activities of catalase and superoxide dismutase and induced an increase in glutathionecontent and inhibited lipid peroxidation in the skin. These findings reveal the chemopreventive efficacy of BA and also demonstrate that it contributes to the cytotoxic and antioxidative effects of Barringtonia racemosa fruits. The study also validates the traditional claims of Barringtonia fruits and provides a scientific basis of its chemopreventive property.

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Icacinaceae Plant Family: A Recapitulation of the Ethnobotanical, Phytochemical, Pharmacological, and Biotechnological Aspects

Deb

Hazarika

Borah

et al. 2023

CPD

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Icacinaceae, an Angiospermic family comprising 35 genera and 212 accepted species, including trees, shrubs, and lianas with pantropical distribution, is one of the most outshining yet least explored plant families, which despite its vital role as a source of pharmaceuticals and nutraceuticals has received a meagre amount of attraction from the scientific community. Interstingly, Icacinaceae is considered a potential alternative resource for camptothecin and its derivatives, which are used in treating ovarian and metastatic colorectal cancer. However, the concept of this family has been revised many times, but further recognition is still needed. The prime objective of this review is to compile the available information on this family in order to popularize it in the scientific community and the general population and promote extensive exploration of these taxa. The phytochemical preparations or isolated compounds from the Icacinaceae family have been centrally amalgamated to draw diverse future prospects from this inclusive plant species. The ethnopharmacological activities and the associated endophytes and cell culture techniques are also depicted. Nevertheless, the methodical evaluation of the Icacinaceae family is the only means to preserve and corroborate the folkloristic remedial effects and provide scientific recognition of its potencies before they are lost under the blanket of modernization.

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Attenuation of DMBA/croton oil induced mouse skin papilloma byApodytes dimidiatamediated by its antioxidant and antimutagenic potential

Cited by 3 publications

References 35 publications

Ameliorative effect ofApodytes dimidiataon cisplatin-induced nephrotoxicity in Wistar rats

Ameliorative effect ofApodytes dimidiataon cisplatin-induced nephrotoxicity in Wistar rats

Chemomodulatory Potential of Bartogenic Acid Against DMBA/Croton Oil Induced Two-Step Skin Carcinogenesis in Mice

Icacinaceae Plant Family: A Recapitulation of the Ethnobotanical, Phytochemical, Pharmacological, and Biotechnological Aspects

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