Ameliorative effect ofApodytes dimidiataon cisplatin-induced nephrotoxicity in Wistar rats

Abstract

Context Nutraceuticals possessing antioxidant potential have been used to alleviate side effects exerted by many chemotherapeutics, including cisplatin. Since Apodytes dimidiata E. Mey. Ex Arn. (Icacinaceae) shows antioxidant potential, it may possess significant chemoprotective effects. Objectives The study investigated whether A. dimidiata could attenuate cisplatin-induced renal damage. Materials and methods Nephrotoxicity was induced by cisplatin (single i.p., 16 mg/kg b wt.) in Wistar rats. Methanolic leaf extract of A. dimidiata (AMF) was administered at a dose of 250 mg/kg b. wt. orally for 5 consecutive days before/after cisplatin administration. Blood and renal parameters were analysed. Total phenolic and flavonoid content in AMF and its NO scavenging effect was determined. Results Significant protective effect of AMF on cisplatin-induced nephrotoxicity was observed in pre-treated animals. The reduction of urea, creatinine and lipid peroxidation was 58.31%, 42.19% and 60%, respectively, and the increase in haemoglobin and leucocyte count was 28.25% and 42.91%, respectively. The increase calculated for GSH, GP x, SOD and catalase was 35.64%, 18.14%, 74.42% and 35.46%, respectively. Tissue architecture of kidney was almost normal in AMF treated animals. The results were comparable to the standard drug, silymarin. AMF contained high level of polyphenols and flavonoids and was found to scavenge NO radicals (IC 50 121.8 mg/mL). Discussion and conclusion AMF can effectively counteract cisplatin mediated renal acute toxicity possibly by scavenging reactive oxygen and nitrogen species. Accordingly, the study suggests that AMF can ameliorate free radical-induced damage associated with chemotherapeutic drugs. ARTICLE HISTORY

Salvianolic Acid C Protects against Cisplatin-Induced Acute Kidney Injury through Attenuation of Inflammation, Oxidative Stress and Apoptotic Effects and Activation of the CaMKK–AMPK–Sirt1-Associated Signaling Pathway in Mouse Models

“…Experimental and clinical trials have shown that AMF does not alter the antitumor activity of chemotherapy or radiotherapy. AMF is currently recommended for the prevention of cisplatin-induced nephrotoxicity [39][40][41]. In this study, we used AMF and SAC to treat cisplatin-induced AKI were effective in vivo.…”

Protective effect of rutin supplementation against cisplatin-induced Nephrotoxicity in rats

“…The development of renal tubule injury is caused by the oxidative stress induced by cisplatin [9–12]. The reactive oxygen species (ROS) and reactive nitrogen species (RNS) production [13] alter the structure and function of cellular membranes [14]. In addition to their accumulation in kidney and lysosomes [15] explained the mechanisms for CP-induced acute nephropathy [13].…”

A Combination of Rosa Canina Extracts and Gold Complex Favors Apoptosis of Caco-2 Cells by Increasing Oxidative Stress and Mitochondrial Dysfunction

“…Therefore, the use of whole-plant extracts and/or isolated fractions that contain more than one bioactive compound might be a better approach to cancer therapy due to the additive effect of single agents. In line with this thinking, plant extracts have been proposed as promising adjuvants for chemotherapeutic drugs in order to enhance their effectiveness [3,4] as well as to improve its cytotoxicity on healthy tissue [5,6].…”