Attenuation of diabetic nephropathy by Sanziguben Granule inhibiting EMT through Nrf2-mediated anti-oxidative effects in streptozotocin (STZ)-induced diabetic rats

Zhang, Chenxue; Li, Qian; Lai, Sisi; Yang, Lei; Shi, Guoqi; Wang, Qing; Luo, Zhihan; Zhao, Ruizhi; Yu, Yang

doi:10.1016/j.jep.2017.05.009

Cited by 28 publications

(15 citation statements)

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“…Sanziguben Granule ( SZGB ) can restrain EMT through antioxidative stress effects by stimulating the nuclear factor erythroid-2-related factor 2 (Nrf2) signaling pathway, which is a crucial regulator to counteract oxidative stress and regulate intracellular antioxidants. SZGB is a compound prescription made from four kinds of Chinese herbs, namely, Rosa laevigata Michx , Gynostemma pentaphyllum , Phyllanthus emblica , and Fructus Schizandrae [60]. CHM can delay the progression of DKD by reducing AGE and the inflammatory response mediated by ROS, regulating the balance of oxidative stress indicators.…”

Section: The Action Mechanisms Of Chm On Dkdmentioning

confidence: 99%

The Efficacy and Mechanism of Chinese Herbal Medicine on Diabetic Kidney Disease

Zhong

Liu

et al. 2019

Journal of Diabetes Research

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Diabetic kidney disease (DKD) is the most common microvascular complication of diabetes and is one of the main causes of end-stage renal disease (ESRD) in many countries. The pathological features of DKD are the hypertrophy of mesangial cells, apoptosis of podocytes, glomerular basement membrane (GBM) thickening, accumulation of extracellular matrix (ECM), glomerular sclerosis, and tubulointerstitial fibrosis. The etiology of DKD is very complicated and many factors are involved, such as genetic factors, hyperglycemia, hypertension, hyperlipidemia, abnormalities of renal hemodynamics, and metabolism of vasoactive substances. Although some achievements have been made in the exploration of the pathogenesis of DKD, the currently available clinical treatment methods are still not completely effective in preventing the progress of DKD to ESRD. CHM composed of natural products has traditionally been used for symptom relief, which may offer new insights into therapeutic development of DKD. We will summarize the progress of Chinese herbal medicine (CHM) in the treatment of DKD from two aspects. In clinical trials, the Chinese herbal formulas were efficacy and safety confirmed by the randomized controlled trials. In terms of experimental research, studies provided evidence for the efficacy of CHM from the perspectives of balancing metabolic disorders, reducing inflammatory response and oxidative stress, antifibrosis, protecting renal innate cells, and regulating microRNA and metabolism. CHM consisting of different ingredients may play a role in synergistic interactions and multiple target points in the treatment of DKD.

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Section: The Action Mechanisms Of Chm On Dkdmentioning

confidence: 99%

The Efficacy and Mechanism of Chinese Herbal Medicine on Diabetic Kidney Disease

Zhong

Liu

et al. 2019

Journal of Diabetes Research

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“…The first critical event and trigger of the development of atherosclerosis is the chronic injury and activation of endothelial cells through different insults including hyperglycemia, hypertension, hyperlipidemia as well as redox-/ER-stress and inflammation. All those features are characteristic for (type 2) DM and may be counteracted by Nrf2 activation (Dong et al, 2017; Giacco and Brownlee, 2010; Gupte et al, 2013; Shah and Brownlee, 2016; Cheng Zhang et al, 2017a). In particular, the Nrf2 target genes HMOX-1, NQO-1 or metallothioneine have gained interest with regard to potential protection from atherosclerosis or restenosis (Ayer et al, 2016; Calay and Mason, 2014; Chapple et al, 2012; Cominacini et al, 2015; He et al, 2015; Mason, 2016; Miao et al, 2013; Mylroie et al, 2015; Oh et al, 2014).…”

Section: Diabetes-associated Complicationsmentioning

confidence: 99%

Activation of Nrf2 signaling by natural products-can it alleviate diabetes?

Matzinger

Fischhuber

Heiss

2018

Biotechnology Advances

171

105

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Type 2 diabetes mellitus (DM) has reached pandemic proportions and effective prevention strategies are wanted. Its onset is accompanied by cellular distress, the nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor boosting cytoprotective responses, and many phytochemicals activate Nrf2 signaling. Thus, Nrf2 activation by natural products could presumably alleviate DM. We summarize function, regulation and exogenous activation of Nrf2, as well as diabetes-linked and Nrf2-susceptible forms of cellular stress. The reported amelioration of insulin resistance, β-cell dysfunction and diabetic complications by activated Nrf2 as well as the status quo of Nrf2 in precision medicine for DM are reviewed.

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“…The lowering in the body weights might be an indication of a decrease in the rate of protein synthesis coupled with an excessive breakdown of structural proteins as an alternative This article can be downloaded from www.ijlpr.com L-30 source of energy due to the low availability of carbohydrates 19 . Renal hypertrophy may be due to the expansion of extracellular matrices which is prominent in diabetic nephropathy 20 . Administration of CFE and /or PDE appreciably restored the animal body weights and reduced the renal weight in the diabetic treated rat group.…”

Section: Discussionmentioning

confidence: 99%

Rescue of Inflammatory Renal Damage by Medicinal Plant Extracts in Diabetic Rats

Saddiq¹,

Mohamed²

2019

Int J Life Sci Pharm Res

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Diabetic nephropathy (DN) is the most critical diabetic complication that leads to renal failure. The purpose of this research was to explore the anti-diabetic effectiveness of Cucumis melo var. flexuosus and/or Phoenix dactylifera fruit aqueous extracts and their mechanisms in alleviating nephropathy in hyperglycemic rats. Diabetes was promoted in rats by injection (i.p.) of a single dose of streptozotocin (STZ). C. flexuosus and P. dactylifera extracts (CFE and PDE respectively) were ingested to diabetic rats for thirty consecutive days. The data revealed that intake of either plant extract or their combination to diabetic rats, significantly diminished the serum glucose and raised the serum insulin concentration. The plant extracts significantly ameliorated the increases in relative kidney weights as well as in renal tumor necrosis factor (TNF-α), serum C -reactive protein (CRP) and renal vascular endothelial factor (VEGF). Serum kidney function markers (creatinine, uric acid and urea) were also decreased in diabetic rats treated with the plant extracts. Histopathological observation was also carried out to confirm the biochemical results. This study has proven that the current plant extracts have potential hypoglycemic effect and could attenuate diabetic inflammatory renal damage in rats. The combination of the two extracts was synergistically the effective one. This result may help in exploring a novel therapy to manage diabetes and its complications.

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Attenuation of diabetic nephropathy by Sanziguben Granule inhibiting EMT through Nrf2-mediated anti-oxidative effects in streptozotocin (STZ)-induced diabetic rats

Cited by 28 publications

References 50 publications

The Efficacy and Mechanism of Chinese Herbal Medicine on Diabetic Kidney Disease

The Efficacy and Mechanism of Chinese Herbal Medicine on Diabetic Kidney Disease

Activation of Nrf2 signaling by natural products-can it alleviate diabetes?

Rescue of Inflammatory Renal Damage by Medicinal Plant Extracts in Diabetic Rats

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