Attenuation of cocaine-induced elevation of nucleus accumbens dopamine in lead-exposed rats

Nation, Jack R.; Burkey, Robert T.

doi:10.1016/0361-9230(94)90223-2

Cited by 9 publications

(4 citation statements)

References 24 publications

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“…Thus, chronic lead exposure caused cocaine-induced disturbance attenuation in fixed-interval responding (Burkey et al, 1997). In agreement with these data, there are studies showing attenuated cocaine-induced increases in extracellular dopamine levels in the nucleus accumbens region after chronic lead exposure (Nation & Burkey, 1994).…”

Section: Environmental Neurotoxicants and Drug Abusesupporting

confidence: 74%

Interaction Between Exposure to Neurotoxicants and Drug Abuse

Carvajal¹,

Sanchez-Amate²,

Lerma-Cabrera³

et al. 2012

Environmental Health - Emerging Issues and Practice

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Section: Environmental Neurotoxicants and Drug Abusesupporting

confidence: 74%

Interaction Between Exposure to Neurotoxicants and Drug Abuse

Carvajal¹,

Sanchez-Amate²,

Lerma-Cabrera³

et al. 2012

Environmental Health - Emerging Issues and Practice

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“…In addition, in a subsequent investigation of the effects of cocaine on schedule-controlled responding, adult animals exposed to lead were found to be less responsive to the rate-enhancing effects of cocaine (Burkey et al 1997). Consistent with this pattern of diminished behavioral sensitivity to cocaine in the adult lead-exposure case, cocaine-induced elevation of nucleus accumbens dopamine levels is attenuated by chronic lead exposure in the adult (Nation and Burkey 1994). Indeed, given that diminished mesolimbic dopamine synthesis is evident in lead-exposed adults even in the absence of a drug challenge (Lasley and Lane 1988), metal-based antagonism of behavioral responsiveness to cocaine would be expected, at least insofar as dopamine availability and consequent regulatory changes are integral to the development and expression of cocaine effects (Hemby et al 1999;Wise and Bozarth 1987).…”

Section: Discussionmentioning

confidence: 75%

Developmental Lead Exposure Alters the Stimulatory Properties of Cocaine at PND 30 and PND 90 in the Rat

Nation

Miller

Bratton

2000

Neuropsychopharmacology

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The aim of this study was to examine the effects of perinatal lead exposure on locomotor responding following acute and repeated cocaine challenges (sensitization).Lead poisoning continues to present major health concerns nationwide, and this situation is especially problematic among children. Recent sociodemographic data indicate the threat of lead toxicity is especially great among economically disadvantaged, nonwhite, and inner-city children (Goldman and Carra 1994;Pirkle et al. 1994). Along these lines, a 1999 report alarmingly places the "at risk" figure for children suffering from excessive lead exposure at around 70% in major metropolitan areas of the United States (cf., Mielke 1999).The sizable literature on developmental lead poisoning understandably has focused on global disturbances produced by early contaminant exposure that may have an enduring impact on the quality of life. In this sense, the data are compelling with respect to showing that even low-level lead exposure during development can occasion long-lasting neurobehavioral disturbances that compromise adult adaptive abilities and threaten stability. In this regard, functional deficits in cognitive and intellectual processing have been shown to persist well into the adult cycle of humans, rodents, and nonhuman primates (e.g., Bellinger et al. 1987). In addition, it seems that even emotional expression and attendant psychosocial phenomena may be influenced by lead ex- N EUROPSYCHOPHARMACOLOGY 2000 -VOL . 23 , NO . 4 Developmental Lead Exposure and Cocaine 445 posure during early development (Needleman et al. 1996).In the present report, our objective was to investigate interactive relations between developmental lead exposure and drug sensitivity later in the life cycle. This is an especially pertinent issue given that lead uniquely threatens sub-populations where drug abuse is more common, i.e., urban minorities . Clearly, experiential elements, availability, drug history, poverty, etc., must be considered in the list of dispositional factors that determine drug habits in humans. But it also must be considered that other types of environmental events may contribute to the abuse potential of selective drugs. That is, to the extent that lead or any other xenobiotic chemical alters the impact of a set delivery of a drug, motivational features related to drug seeking and taking may be redefined and therein influence maintenance responding and/or the effectiveness of certain pharmacotherapies for drug abuse (Mello et al. 1995).The development of behavioral sensitization during repeated administration of psychomotor stimulants is a well-characterized phenomenon which has received considerable attention because of its proposed relevance to drug addiction (Robinson and Berridge 1993;Wise and Bozarth 1987;Wolf et al. 1995) and psychosis (Post et al. 1992;Segal and Schuckit 1983). Therefore, the procedure was employed here in an effort to determine the effects of lead exposure during lactation and gestation on cocaine-induced changes in locomotor re...

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“…Nation and Burkey () exposed adult rats to lead in drinking water for 2 months and then employed microdialysis in the nucleus accumbens to compare the response of extracellular dopamine in exposed and control animals after 10 mg/kg i.p. cocaine.…”

Section: Microdialysis In Neurotoxicology: Environmental Agentsmentioning

confidence: 99%

“…Furthermore, because of lead's neurobehavioral effects in children resulting from exposure during early development, many studies have utilized widely available analytical methods to investigate biogenic amine and amino acid neurotransmitter function in animals. Nation and Burkey (1994) exposed adult rats to lead in drinking water for 2 months and then employed microdialysis in the nucleus accumbens to compare the response of extracellular dopamine in exposed and control animals after 10 mg/kg i.p. cocaine.…”

Section: Leadmentioning

confidence: 99%

The Use of Intracerebral Microdialysis to Elucidate Environmentally Induced Neurotoxic Mechanisms

Lasley

2019

CP Toxicology

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The technique of microdialysis permits the assessment of neurotransmitter activity and the monitoring of other cellular entities in tissue extracellular fluid. The method is widely used for quantifying biogenic amine and amino acid transmitters, peptides, administered drugs, and other molecules in response to various experimental treatments. This article provides an overview of the manner in which the methodology of intracerebral microdialysis is utilized in the field of neurotoxicology to elucidate the actions of environmental agents. The technique is employed in a variety of creative ways to address specific experimental goals involving myriad toxicants. With appropriate consideration of method parameters, investigators have also been able to address mechanistic issues in their studies. These investigations consist of sampling of neurotransmitters in extracellular fluid after various protocols of environmental metal exposure as well as assessments of blood–brain barrier permeability, the detection of reactive oxygen species, and description of the toxicodynamics of environmental agents. The purpose of this examination is not to review the investigational findings, per se, but to highlight the various approaches utilized with this methodology and the experimental questions that have been addressed. © 2019 by John Wiley & Sons, Inc.

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Attenuation of cocaine-induced elevation of nucleus accumbens dopamine in lead-exposed rats

Cited by 9 publications

References 24 publications

Interaction Between Exposure to Neurotoxicants and Drug Abuse

Interaction Between Exposure to Neurotoxicants and Drug Abuse

Developmental Lead Exposure Alters the Stimulatory Properties of Cocaine at PND 30 and PND 90 in the Rat

The Use of Intracerebral Microdialysis to Elucidate Environmentally Induced Neurotoxic Mechanisms

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