Attenuating Chronic Fibrosis: Decreasing Foreign Body Response with Acellular Dermal Matrix

Liang, Norah E.; Berry, Charlotte E.; Parker, J. M. R.; Downer, Mauricio; Wan, Derrick C.; Longaker, Michael T.

doi:10.1089/ten.teb.2023.0060

Cited by 7 publications

(4 citation statements)

References 80 publications

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“…Previous studies had indicated that the fibrotic capsule around the implants can lead to devices failure and mechanical impairment. 37,38 The formation of the capsule is influenced by several factors, including properties of the implants, surface texture, and implantation site. 27,39 Our descriptive histologic analysis showed thinner fibrotic capsule around implants in omental group when compared with capsule in control group.…”

Section: Discussionmentioning

confidence: 99%

Omental coating attenuates implant-induced foreign body reaction in rats

Guan,

Lu,

Zhang

et al. 2024

J Biomater Appl

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The objective of this study is to clarify whether the omental coating can effectively attenuate foreign body reaction (FBR) induced by implanted materials. Male Sprague-Dawley rats were injected with polydextran particle slurry intraperitoneally to activate the omentum. 7 days later, polyether polyurethane sponge discs were implanted subcutaneously on each side of the rat’s back as the foreign implants to induce FBR. The next day, omental transposition were performed. The disc on the left side of each rat’s back was wrapped with omental flap (omental group); the disc on the right side was untreated (control group). All discs were removed 21 days after implantation and assessed by determining the components of the fibrovascular tissue (angiogenesis, inflammation, foreign body giant cells (FBGCs) aggregation and fibrogenesis). In implants in omental group, micro vessel density (MVD), Hemoglobin (Hb) content and VEGF levels (pro-angiogenic cytokine) were increased when compared with implants from control group. Inflammatory parameters (IL-1β; macrophage accumulation-NAG activity; neutrophil accumulation- MPO levels) were decreased in implants after omental coating. Also, collagen deposition, fibrous capsule thickness, and FBGCs decreased in implants from omental group. However, intra-implant levels of TNF-α and TGF-β1 were not different after omental coating. Our findings showed for the first time that the omental coating around the implants attenuate the adverse FBR, it may be critical in developing new strategies to control FBR and improve the function and performance of the implanted materials.

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Section: Discussionmentioning

confidence: 99%

Omental coating attenuates implant-induced foreign body reaction in rats

Guan,

Lu,

Zhang

et al. 2024

J Biomater Appl

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“…Numerous types of biomaterials-including natural, synthetic, and chimeric materials-have been studied; these materials simulate scaffolds of the ECM of IVD. Although synthetic and chimeric materials can be structurally sturdy, their application in clinical use is likely limited due to the likelihood of foreign body reactions [265].…”

Section: Discussion-highlights Limitations and Future Perspectivesmentioning

confidence: 99%

A Review: Methodologies to Promote the Differentiation of Mesenchymal Stem Cells for the Regeneration of Intervertebral Disc Cells Following Intervertebral Disc Degeneration

Ohnishi,

Homan,

Fukushima

et al. 2023

Cells

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Intervertebral disc (IVD) degeneration (IDD), a highly prevalent pathological condition worldwide, is widely associated with back pain. Treatments available compensate for the impaired function of the degenerated IVD but typically have incomplete resolutions because of their adverse complications. Therefore, fundamental regenerative treatments need exploration. Mesenchymal stem cell (MSC) therapy has been recognized as a mainstream research objective by the World Health Organization and was consequently studied by various research groups. Implanted MSCs exert anti-inflammatory, anti-apoptotic, and anti-pyroptotic effects and promote extracellular component production, as well as differentiation into IVD cells themselves. Hence, the ultimate goal of MSC therapy is to recover IVD cells and consequently regenerate the extracellular matrix of degenerated IVDs. Notably, in addition to MSC implantation, healthy nucleus pulposus (NP) cells (NPCs) have been implanted to regenerate NP, which is currently undergoing clinical trials. NPC-derived exosomes have been investigated for their ability to differentiate MSCs from NPC-like phenotypes. A stable and economical source of IVD cells may include allogeneic MSCs from the cell bank for differentiation into IVD cells. Therefore, multiple alternative therapeutic options should be considered if a refined protocol for the differentiation of MSCs into IVD cells is established. In this study, we comprehensively reviewed the molecules, scaffolds, and environmental factors that facilitate the differentiation of MSCs into IVD cells for regenerative therapies for IDD.

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“…Additionally, both AAM and SIS generate antimicrobial substances during the degradation process, which contributes to their antibacterial capability [ 71 , 72 ]. Regarding immunogenicity, although the precise mechanism by which ADM mitigates chronic fibrosis is not yet fully understood, animal studies have shown its biomimetic properties in reducing periprosthetic inflammation and enhancing host cell integration [ 73 ]. Furthermore, research has indicated that AAM not only minimizes immune rejection of implanted membranes compared to intact amniotic membrane but also enhances cell attachment and differentiation through the retained collagen [ 74 ].…”

Section: Overview Of Sismentioning

confidence: 99%

The application of small intestinal submucosa in tissue regeneration

Zhao,

Peng,

Sun

et al. 2024

Materials Today Bio

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Attenuating Chronic Fibrosis: Decreasing Foreign Body Response with Acellular Dermal Matrix

Cited by 7 publications

References 80 publications

Omental coating attenuates implant-induced foreign body reaction in rats

Omental coating attenuates implant-induced foreign body reaction in rats

A Review: Methodologies to Promote the Differentiation of Mesenchymal Stem Cells for the Regeneration of Intervertebral Disc Cells Following Intervertebral Disc Degeneration

The application of small intestinal submucosa in tissue regeneration

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