The application of small intestinal submucosa in tissue regeneration

Zhao, Yifan; Peng, Hongyi; Sun, Lingxiang; Tong, Jiahui; Cui, Chenying; Bai, Ziyang; Yan, Jingyu; Qin, Danlei; Liu, Yingyu; Wang, Jue; Wu, Xiuping; Li, Bing

doi:10.1016/j.mtbio.2024.101032

Materials Today Bio

2024

DOI: 10.1016/j.mtbio.2024.101032

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The application of small intestinal submucosa in tissue regeneration

Yifan Zhao,

Hongyi Peng,

Lingxiang Sun

et al.

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2024

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Cited by 1 publication

References 169 publications

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EVs from cells at the early stages of chondrogenesis delivered by injectable SIS dECM promote cartilage regeneration

Zhu,

Shi,

Weng

et al. 2024

J Tissue Eng

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Articular cartilage defect therapy is still dissatisfactory in clinic. Direct cell implantation faces challenges, such as tumorigenicity, immunogenicity, and uncontrollability. Extracellular vesicles (EVs) based cell-free therapy becomes a promising alternative approach for cartilage regeneration. Even though, EVs from different cells exhibit heterogeneous characteristics and effects. The aim of the study was to discover the functions of EVs from the cells during chondrogenesis timeline on cartilage regeneration. Here, bone marrow mesenchymal stem cells (BMSCs)-EVs, juvenile chondrocytes-EVs, and adult chondrocytes-EVs were used to represent the EVs at different differentiation stages, and fibroblast-EVs as surrounding signals were also joined to compare. Fibroblasts-EVs showed the worst effect on chondrogenesis. While juvenile chondrocyte-EVs and adult chondrocyte-EVs showed comparable effect on chondrogenic differentiation as BMSCs-EVs, BMSCs-EVs showed the best effect on cell proliferation and migration. Moreover, the amount of EVs secreted from BMSCs were much more than that from chondrocytes. An injectable decellularized extracellular matrix (dECM) hydrogel from small intestinal submucosa (SIS) was fabricated as the EVs delivery platform with natural matrix microenvironment. In a rat model, BMSCs-EVs loaded SIS hydrogel was injected into the articular cartilage defects and significantly enhanced cartilage regeneration in vivo. Furthermore, protein proteomics revealed BMSCs-EVs specifically upregulated multiple metabolic and biosynthetic processes, which might be the potential mechanism. Thus, injectable SIS hydrogel loaded with BMSCs-EVs might be a promising therapeutic way for articular cartilage defect.

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EVs from cells at the early stages of chondrogenesis delivered by injectable SIS dECM promote cartilage regeneration

Zhu,

Shi,

Weng

et al. 2024

J Tissue Eng

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The application of small intestinal submucosa in tissue regeneration

Cited by 1 publication

References 169 publications

EVs from cells at the early stages of chondrogenesis delivered by injectable SIS dECM promote cartilage regeneration

EVs from cells at the early stages of chondrogenesis delivered by injectable SIS dECM promote cartilage regeneration

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