Attenuated mumps virus therapy of carcinoma of the maxillary sinus

Sato, Mitsunobu; Urade, Masahiro; Sakuda, Masayoshi; Shirasuna, Kanemitsu; Yoshida, Hideo; Maeda, Noriaki; Yanagawa, Tetsuo; Morimoto, Manabu; Yura, Yoshiaki; Miyazaki, Tadashi; Okuno, Yoshihiko; Takahashi, Michiaki

doi:10.1016/s0300-9785(79)80020-4

Cited by 8 publications

(8 citation statements)

References 12 publications

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“…Tables I through IV summarize the collective published experience with maxillary and sphenoid benign and malignant tumors according to histopathology and incidence. 7–50 , 51–100 , 101–150 , 151–200 , 201–250 , 251–300 , 301–350 , 351–400 , 401–450 , …”

Section: Resultsmentioning

confidence: 99%

Factors in the Pathogenesis of Tumors of the Sphenoid and Maxillary Sinuses: A Comparative Study

Reino

2000

The Laryngoscope

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Objectives/Hypothesis To explain the processes that lead to the development of tumors in the maxillary and sphenoid sinuses. Study Design A 32‐year review of the world's literature on neoplasms of these two sinuses and a randomized case‐controlled study comparing the normal mucosal architecture of the maxillary to the sphenoid sinus. Methods Analysis of a 32‐year world literature review reporting series of cases of maxillary and sphenoid sinus tumors. Tumors were classified by histological type and separated into subgroups if an individual incidence rate was reported. Histomorphometry of normal maxillary and sphenoid sinus mucosa was performed in 14 randomly selected patients (10 sphenoid and 4 maxillary specimens). Specimens were fixed in 10% formalin, embedded in paraffin, and stained with periodic acid–Schiff (PAS) and hematoxylin. Histomorphometric analysis was performed with a Zeiss Axioscope light microscope (Carl Zeiss Inc., Thornwood, NY) mounted with a Hamamatsu (Hamamatsu Photonics, Tokyo, Japan) color‐chilled 3 charge coupled device digital camera. The images were captured on a 17‐inch Sony (Sony Corp., Tokyo, Japan) multiscan monitor and analyzed with a Samba 4000 Image Analysis Program (Samba Corp., Los Angeles, CA). Five random areas were selected from strips of epithelium removed from each sinus, and goblet and basal cell measurements were made at magnifications ×100 and ×400. Results The literature review revealed that the number and variety of tumors in the maxillary sinus are much greater than those in the sphenoid. The incidence of metastatic lesions to each sinus is approximately equal. No recognized pattern of spread from any particular organ system could be determined. On histomorphometric study there were no statistically significant differences between the sinuses in the concentration of goblet cells, basal cells, or seromucinous glands. Conclusions Factors involved in the pathogenesis of tumors of the maxillary and sphenoid sinuses include differences in nasal physiology, embryology, morphology, and topography. There are no significant histological differences in the epithelium and submucous glands between the two sinuses to explain the dissimilar formation of neoplasms.

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Section: Resultsmentioning

confidence: 99%

Factors in the Pathogenesis of Tumors of the Sphenoid and Maxillary Sinuses: A Comparative Study

Reino

2000

The Laryngoscope

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“…This feature makes MuV a desirable candidate for the treatment of various cancers. Accordingly, different strains of MuV, derived from different isolates, have been examined as OVs (5,(7)(8)(9)(10)(11)(12)(13)(14)(15)(16).…”

Section: Discussionmentioning

confidence: 99%

“…MuV has long been used as an anti-tumor agent in preclinical (7) and uncontrolled clinical trials (8)(9)(10). Limited studies have been recently conducted in this area.…”

Section: Introductionmentioning

confidence: 99%

Intrinsic Oncolytic Activity of Hoshino Mumps Virus Vaccine Strain Against Human Fibrosarcoma and Cervical Cancer Cell Lines

et al. 2020

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Background: The use of oncolytic viruses as therapeutic agents is a promising treatment for various human cancers. Several viruses have been extensively examined to achieve tumor cell death. Objectives: This study aimed at evaluating the natural oncolytic activity of mumps Hoshino vaccine strain against two human cancer cell lines, that is, HT1080 fibrosarcoma and HeLa cervical adenocarcinoma cell lines. Methods: The cytolytic activity of the virus was evaluated using an MTT assay. Apoptosis was detected by Annexin-V/propidium iodide (PI) staining and analyzed via flow cytometry. To indicate viral replication in vivo, nude mice with HeLa heterografts were treated with the Hoshino strain of mumps virus. Results: It was found that human fibrosarcoma and cervical cells were more sensitive to the mumps Hoshino strain, even at a very low multiplicity of infection (MOI) compared to normal human diploid cells. The results also showed that the Hoshino strain induced apoptosis in both cancer cells. A preliminary in vivo study revealed the significant suppression of tumor growth in the group treated with the mumps Hoshino strain compared to the control group. Conclusions: The Hoshino vaccine strain of mumps virus showed promising oncolytic activities against human fibrosarcoma and cervical adenocarcinoma cells.

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“…Retrospectively, the concept of viruses as anti-cancer agents was originated following the historical observ-ations suggesting that the infections of leukemic patient (16) with certain pathogens had beneficial anti-cancer effects, even inducing the remission of the cancer in some cases (43). Such a potential of infectious agents to selectively target and destroy cancerous cells was further supported by the sporadic reports documenting tumor regression in patients with coincidental viral infections such as measles (21,42, reviewed in 28), viral hepatitis (25,50), chicken pox (8), mumps virus (4,47) and many others (reviewed in 28). These observations led to the foundation of modern day cancer virotherapy.…”

Section: Introductionmentioning

confidence: 92%

Reovirus oncolysis: a brief insight on molecular mechanism and immunological aspect

Gujar

Lee

2007

Iran J Virol

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: Reovirus (respiratory enteric orphan virus), a naturally occurring benign human pathogen, has an inherent ability to target transformed and cancerous cells and cause their lysis, while leaving non-transformed cells relatively unaffected. The efficiency of this innate oncolytic activity of reovirus correlates with expression of the ras oncogene. Cells expressing activated Ras and the related Ras/RalGEF/p38 pathway are more permissive to the reovirus infection than that of untransformed counterparts. Ras-transformation orchestrates selective oncolysis of cancerous cells by mediating efficient virus uncoating as well as by enhancing infectivity and subsequent apoptosis-dependent release of nascent virus particles. Different human and murine cell lines derived from naturally occurring tumors also display similar activation of the ras pathway, and thus present selective susceptibility to reovirus oncolysis under in vitro as well as in vivo conditions. This ability of reovirus to selectively target a wide variety of tumors offers a novel anti-cancer therapeutic option. However, the efficiency of reovirus virotherapy in immunocompetent hosts is compromised due to the presence of anti-viral innate and adaptive immune responses. Hence, the success of this highly promising reovirus oncolytic therapy will likely be enhanced by modulating host immunity.

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Attenuated mumps virus therapy of carcinoma of the maxillary sinus

Cited by 8 publications

References 12 publications

Factors in the Pathogenesis of Tumors of the Sphenoid and Maxillary Sinuses: A Comparative Study

Factors in the Pathogenesis of Tumors of the Sphenoid and Maxillary Sinuses: A Comparative Study

Intrinsic Oncolytic Activity of Hoshino Mumps Virus Vaccine Strain Against Human Fibrosarcoma and Cervical Cancer Cell Lines

Reovirus oncolysis: a brief insight on molecular mechanism and immunological aspect

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