Attentional Selection and Suppression in Children With Attention-Deficit/Hyperactivity Disorder

Wang, Encong; Sun, Li; Sun, Mengjun; Huang, Jing; Tao, Ye; Zhao, Xixi; Wu, Zhanliang; Ding, Yulong; Newman, Daniel P.; Bellgrove, Mark A.; Wang, Yufeng; Song, Yan

doi:10.1016/j.bpsc.2016.01.004

Cited by 29 publications

(43 citation statements)

References 41 publications

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“…As in many prior experiments, we anticipated that attention would initially be deployed towards the location of the target, leading to an N2pc in both children and adults (Eimer, ; Luck & Hillyard, , ; Wang et al., ). Besides, we predicted that the N2pc component would be followed by a contralateral positivity (P D ) component (Jannati et al., ; Sawaki et al., ; Wang et al., ), reflecting active suppression that terminates the allocation of attention to the lateral target. In Experiment 1, we used the N2pc and P D components to investigate whether differences exist between children and adults in the ERP marker of attention selection or in the subsequent suppression process.…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, N2pc latency was prolonged in adults with ADHD (Cross‐Villasana et al., ) as well as highly schizotypal adults (Fuggetta, Bennett, & Duke, ). N2pc amplitude was reported to be reduced in children with low working memory capacity (Shimi et al., ), children with ADHD (Wang et al., ) and adults with schizophrenia (Verleger, Talamo, Simmer, Smigasiewicz, & Lencer, ). Taken together, these findings suggest that N2pc is a robust biomarker of attentional selection that is sensitive to normal development, aging, and psychiatric diseases.…”

Section: Discussionmentioning

confidence: 99%

“…The N2pc, an enhanced negative potential that is observed contralateral to the attended target, is a well‐known electrophysiological index of attentional selection that emerges over the posterior scalp 200–300 ms after the appearance of a search array (Eimer, ; Luck & Hillyard, , ). By contrast, the P D is an enhanced positive potential that is observed in the same or later time interval (Hickey, Di, & McDonald, ; Wang et al., ). This positivity is elicited when the selective processing of the eliciting stimulus is to be avoided or terminated (Hilimire & Corballis, ; Hilimire, Mounts, Parks, & Corballis, ; Jannati, Gaspar, & McDonald, ; Kiss, Grubert, Petersen, & Eimer, ; Sawaki, Geng, & Luck, ).…”

Section: Introductionmentioning

confidence: 99%

“…However, relatively little is known about how brain electrophysiological activities associated with target selection and distractor suppression are involved as they develop and become fully functional in visual search. To date, only four studies have examined N2pc in children (Couperus & Quirk, ; Shimi et al., ; Shimi, Nobre, & Scerif, ; Wang et al., ). Evidence from these recent ERP studies revealed that, compared with adults, children aged approximately 10 years old showed significant but delayed N2pc (Couperus & Quirk, ; Shimi et al., ).…”

Section: Introductionmentioning

confidence: 99%

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Attentional selection and suppression in children and adults

Sun

Wang

Huang

et al. 2018

Developmental Science

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The fundamental role of covert spatial attention is to enhance the processing of attended items while simultaneously ignoring irrelevant items. However, relatively little is known about how brain electrophysiological activities associated with target selection and distractor suppression are involved as they develop and become fully functional. The current study aimed to identify the neurophysiological bases of the development of covert spatial attention, focusing on electroencephalographic (EEG) markers of attentional selection (N2pc) and suppression (P ). EEG data were collected from healthy young adults and typically developing children (9-15 years old) as they searched for a shape singleton target in either the absence or the presence of a salient-but-irrelevant color singleton distractor. The ERP results showed that a lateral shape target elicited a smaller N2pc in children compared with adults regardless of whether a distractor was present or not. Moreover, the target-elicited N2pc was always followed by a similar positivity in both age groups. Counterintuitively, a lateral salient-but-irrelevant distractor elicited a large P in children with low behavioral accuracy, whereas high-accuracy children exhibited a small and "adult-like" P . More importantly, we found no evidence for a correlation between the target-elicited N2pc and the distractor-elicited P in either age group. Our results provide neurophysiological evidence for the developmental differences between target selection and distractor suppression. Compared with adults, 9-15-year-old children deploy insufficient attentional selection resources to targets but use "adult-like" or even more attentional suppression resources to resist irrelevant distractors. A video abstract of this article can be viewed at: https://www.youtube.com/watch?v=NhWapx0d75I.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Attentional selection and suppression in children and adults

Sun

Wang

Huang

et al. 2018

Developmental Science

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“…There is evidence that N2pc may not be optimal to detect distractor processing even in adults (Eimer et al, 2009). This, coupled with a wealth of evidence for the viability of the N2pc as a marker of target-based attentional selection that is sensitive to healthy development (Wiegand et al 2017;Shimi et al, 2015), aging (Pagano et al, 2015;Wiegand et al, 2013), as well as mental disorders (Fuggetta et al, 2015;Wang et al, 2016), prevents concluding that the N2pc is suboptimal to detect real-world attentional control. Nonetheless, had our analyses stopped at a canonical N2pc approach, one could have concluded that attentional control processes like TAC and MSE are simply not elicited by goal-irrelevant stimuli (cf.…”

Section: The N2pc As a Marker Of Developing Real-world Attentional Comentioning

confidence: 99%

The development of attentional control mechanisms in multisensory environments

Turoman

Tivadar

Retsa

et al. 2020

Preprint

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AbstractAttentional control outside of the laboratory operates in multisensory settings, but the development of mechanisms subserving such control remains poorly understood. We investigated when, over the course of childhood, adult-like attentional control mechanisms begin to emerge. Children aged five, seven, and nine were compared with adults on behavioural performance in a computer game-like multisensory spatial cueing task, while simultaneous 129-channel EEG was recorded. Markers of attentional control were behavioural spatial cueing effects and the N2pc ERP component (analysed both traditionally and using a novel, multivariate electrical neuroimaging framework). In behaviour, adult-like visual attentional control was present from age 7 onwards, whereas multisensory control was not seen in children. In EEG, multivariate analyses of the activity over the N2pc time-window, revealed stable patterns of brain activity in children. Adult activity patterns linked to visual attentional control were present age 7 onwards, mirroring behaviour. Activity patterns linked to multisensory control were found in 9-year-olds, even though such patterns were not noted in behaviour. By combining rigorous yet naturalistic paradigms with multivariate signal analyses, we provided new insights into the development of visual attentional control skills vis-à-vis multisensory attentional control, thus generating a more complete account of attentional development.HighlightsBehaviourally, visual attentional control, as measured by task-set contingent attentional capture, was found to reach an adult-like state as early as age 7Behaviourally, attentional enhancement from multisensory stimuli was not found in 9-year-olds, but their EEG topographic patterns were different for multisensory vs. purely visual distractorsTraditional visual attentional event-related analyses, such as the N2pc, are not sensitive to detect attentional enhancement for multisensory objects in adults, and visual or multisensory attention in childrenSensitive, multivariate analyses of the event-related potential signal, such as electrical neuroimaging, are adept at revealing the neural underpinnings of attentional control processes over development

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Information‐based multivariate decoding reveals imprecise neural encoding in children with attention deficit hyperactivity disorder during visual selective attention

Luo

Guo

et al. 2022

Human Brain Mapping

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Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in school‐age children. Attentional orientation is a potential clinical diagnostic marker to aid in the early diagnosis of ADHD. However, the underlying pathophysiological substrates of impaired attentional orienting in childhood ADHD remain unclear. Electroencephalography (EEG) was measured in 135 school‐age children (70 with childhood ADHD and 65 matched typically developing children) to directly investigate target localization during spatial selective attention through univariate ERP analysis and information‐based multivariate pattern machine learning analysis. Compared with children with typical development, a smaller N2pc was found in the ADHD group through univariate ERP analysis. Children with ADHD showed a lower parieto‐occipital multivariate decoding accuracy approximately 240–340 ms after visual search onset, which predicts a slower reaction time and larger standard deviation of reaction time. Furthermore, a significant correlation was found between N2pc and decoding accuracy in typically developing children but not in children with ADHD. These observations reveal that impaired attentional orienting in ADHD may be due to inefficient neural encoding responses. By using a personalized information‐based multivariate machine learning approach, we have advanced the understanding of cognitive deficits in neurodevelopmental disorders. Our study provides potential research directions for the early diagnosis and optimization of personalized intervention in children with ADHD.

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Attentional Selection and Suppression in Children With Attention-Deficit/Hyperactivity Disorder

Cited by 29 publications

References 41 publications

Attentional selection and suppression in children and adults

Attentional selection and suppression in children and adults

The development of attentional control mechanisms in multisensory environments

Information‐based multivariate decoding reveals imprecise neural encoding in children with attention deficit hyperactivity disorder during visual selective attention

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