Attachment and proliferation of human osteoblast-like cells (MG-63) on laser-ablated titanium implant material

Györgyey, Ágnes; Ungvári, Krisztina; Kecskeméti, Gabriella; Kopniczky, Judit; Hopp, B.; Oszkó, A.; Pelsoczi, Istvan; Rakonczay, Zoltán; Nagy, Katalin; Turzó, Kinga

doi:10.1016/j.msec.2013.06.020

Cited by 72 publications

(47 citation statements)

References 52 publications

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“…E-beam irradiation on Ti has been found to reduce the roughness and to improve the nanohardness of the material [22], allowing for the deposition of smoother CaP layers [23]. Laser treatments have also been studied in order to improve the properties of Ti surfaces [24][25][26][27]. The main effect of laser radiation on metals, such as Ti, is to produce a localized melting of the material, as a result of the heating produced by the absorption if the high density radiation.…”

Section: Surface Treatmentsmentioning

confidence: 99%

“…Thanks to the very strong absorption of radiation in the metal, the melting process involves only a very thin metal layer under the surface, which is quickly recrystallized after the radiation beam is moved to another portion of the surface, while a TiO 2 layer is formed due to the interaction of solidifying metal with air [24]. Several types of lasers have been used for the modification of metals, including ruby, Nd:YAG, argon ion, CO 2 and excimer lasers [26]; however, Nd:YAG seems to be the most experimented laser for the modification of Ti and its alloys for dental implants [24][25][26][27]. Typical values of the process parameters are scanning speeds of 100-300 mm¨s´1, pulse duration of 10-20 ns and pulse energy in the range 0.2-0.5 mJ [25].…”

Section: Surface Treatmentsmentioning

confidence: 99%

“…Typical values of the process parameters are scanning speeds of 100-300 mm¨s´1, pulse duration of 10-20 ns and pulse energy in the range 0.2-0.5 mJ [25]. The morphology of laser-treated Ti is usually characterized by an increased roughness compared to machined Ti surfaces, with typical R a values of 0.5-2 µm [26,27].…”

Section: Surface Treatmentsmentioning

confidence: 99%

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Surface Treatments and Functional Coatings for Biocompatibility Improvement and Bacterial Adhesion Reduction in Dental Implantology

et al. 2016

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Surface modification of dental implants is a key process in the production of these medical devices, and especially titanium implants used in the dental practice are commonly subjected to surface modification processes before their clinical use. A wide range of treatments, such as sand blasting, acid etching, plasma etching, plasma spray deposition, sputtering deposition and cathodic arc deposition, have been studied over the years in order to improve the performance of dental implants. Improving or accelerating the osseointegration process is usually the main goal of these surface processes, but the improvement of biocompatibility and the prevention of bacterial adhesion are also of considerable importance. In this review, we report on the research of the recent years in the field of surface treatments and coatings deposition for the improvement of dental implants performance, with a main focus on the osseointegration acceleration, the reduction of bacterial adhesion and the improvement of biocompatibility.

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Section: Surface Treatmentsmentioning

confidence: 99%

Section: Surface Treatmentsmentioning

confidence: 99%

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Surface Treatments and Functional Coatings for Biocompatibility Improvement and Bacterial Adhesion Reduction in Dental Implantology

et al. 2016

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“…29,30 It has been reported that the attachment of fibroblasts on the biomaterials is more evident on hydrophilic surfaces than hydrophobic ones. 31 In this study, the nHA/PEEK composite significantly promoted the attachment of the MC3T3-E1 cells compared with PEEK and UHMWPE, which may be due to the composite's increased surface hydrophilicity and roughness.…”

mentioning

confidence: 99%

Preparation, characterization, and in vitro osteoblast functions of a nano-hydroxyapatite/polyetheretherketone biocomposite as orthopedic implant material

Ma¹,

Tang²,

Tan³

et al. 2014

IJN

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A bioactive composite was prepared by incorporating 40 wt% nano-hydroxyapatite (nHA) into polyetheretherketone (PEEK) through a process of compounding, injection, and molding. The mechanical and surface properties of the nHA/PEEK composite were characterized, and the in vitro osteoblast functions in the composite were investigated. The mechanical properties (elastic modulus and compressive strength) of the nHA/PEEK composite increased significantly, while the tensile strength decreased slightly as compared with PEEK. Further, the addition of nHA into PEEK increased the surface roughness and hydrophilicity of the nHA/PEEK composite. In cell tests, compared with PEEK and ultra-high-molecular-weight polyethylene, it was found that the nHA/PEEK composite could promote the functions of MC3T3-E1 cells, including cell attachment, spreading, proliferation, alkaline phosphatase activity, calcium nodule formation, and expression of osteogenic differentiation-related genes. Incorporation of nHA into PEEK greatly improved the bioperformance of PEEK. The nHA/PEEK composite might be a promising orthopedic implant material.

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“…27 In this study, the proliferation of MC3T3-E1 cells on the MWC scaffolds increased with time, and the proliferation of the cells on the MWC scaffolds was significantly higher than that on the WP scaffolds. In addition, the ALP activity of cells on the MWC scaffolds showed significantly higher than that on the WP scaffolds, revealing that the addition of nMP into WP promoted cell differentiation.…”

mentioning

confidence: 51%

Degradability, biocompatibility, and osteogenesis of biocomposite scaffolds containing nano magnesium phosphate and wheat protein both in vitro and in vivo for bone regeneration

Xia¹,

Zhou²,

Wang³

et al. 2016

IJN

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In this study, bioactive scaffold of nano magnesium phosphate (nMP)/wheat protein (WP) composite (MWC) was fabricated. The results revealed that the MWC scaffolds had interconnected not only macropores (sized 400–600 μm) but also micropores (sized 10–20 μm) on the walls of macropores. The MWC scaffolds containing 40 w% nMP had an appropriate degradability in phosphate-buffered saline and produced a weak alkaline microenvironment. In cell culture experiments, the results revealed that the MWC scaffolds significantly promoted the MC3T3-E1 cell proliferation, differentiation, and growth into the scaffolds. The results of synchrotron radiation microcomputed tomography and analysis of the histological sections of the in vivo implantation revealed that the MWC scaffolds evidently improved the new bone formation and bone defects repair as compared with WP scaffolds. Moreover, it was found that newly formed bone tissue continued to increase with the gradual reduction of materials residual in the MWC scaffolds. Furthermore, the immunohistochemical analysis further offered the evidence of the stimulatory effects of MWC scaffolds on osteogenic-related cell differentiation and new bone regeneration. The results indicated that MWC scaffolds with good biocompability and degradability could promote osteogenesis in vivo, which would have potential for bone tissue repair.

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Attachment and proliferation of human osteoblast-like cells (MG-63) on laser-ablated titanium implant material

Cited by 72 publications

References 52 publications

Surface Treatments and Functional Coatings for Biocompatibility Improvement and Bacterial Adhesion Reduction in Dental Implantology

Surface Treatments and Functional Coatings for Biocompatibility Improvement and Bacterial Adhesion Reduction in Dental Implantology

Preparation, characterization, and in vitro osteoblast functions of a nano-hydroxyapatite/polyetheretherketone biocomposite as orthopedic implant material

Degradability, biocompatibility, and osteogenesis of biocomposite scaffolds containing nano magnesium phosphate and wheat protein both in vitro and in vivo for bone regeneration

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