Atropine effects on delayed discrimination performance of rats

Elsmore, Timothy F.; Parkinson, John K.; Leu, John R.; Witkin, Jeffrey M.

doi:10.1016/0091-3057(89)90068-3

Cited by 10 publications

(3 citation statements)

References 29 publications

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“…Acetylcholine for memory and attentional processing may be conserved across species as blocking it impairs memory performance in rats, pigeons, monkeys and humans [11,12,17,28,34]. Based on evidence that the cholinergic system is utilized for visual DMTS, we hypothesize that blocking the cholinergic system with scopolamine hydrochloride (ScHCl), a muscarinic cholinergic receptor antagonist, will impair performance of the auditory DMTS task.…”

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confidence: 99%

Scopolamine impairs auditory delayed matching-to-sample performance in monkeys

Plakke

Poremba

2008

Neuroscience Letters

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Information concerning the major neurotransmitters critical for auditory memory is sparse. One possibility is the cholinergic system, important for performance in some tasks requiring visual short-term memory and attention [T.G. Aigner, M. Mishkin, The effects of physostigmine and scopolamine on recognition memory in monkeys, Behav. Neural. Biol. 45 (1986) 81-87; N. Hironaka, K. Ando, Effects of cholinergic drugs on scopolamine-induced memory impairment in rhesus monkeys, Jpn. J. Psychopharmacol. 16 (1996) 103-108; T.M. Myers, G. Galbicka, M.L. Sipos, S. Varadi, J.L. Oubre, M.G. Clark, Effects of anticholinergics on serial-probe recognition accuracy of rhesus macaques (Macaca mulatta), Pharmacol. Biochem. Behav. 73 (2002) 829-834; H. Ogura, T.G. Aigner, MK-801 Impairs recognition memory in rhesus monkeys: comparison with cholinergic drugs, J. Pharmacol. Exp. Ther. 266 (1993) 60-64; D.M. Penetar, J.H. McDonough Jr., Effects of cholinergic drugs on delayed match-to-sample performance of rhesus monkeys, Pharmacol. Biochem. Behav. 19 (1983) 963-967; M.A. Taffe, M.R. Weed, L.H. Gold, Scopolamine alters rhesus monkey performance on a novel neuropsychological test battery, Cogn. Brain Res. 8 (1999) 203-212]. Five rhesus monkeys were trained to perform an auditory go/no-go delayed matching-to-sample (DMTS) task wherein two acoustic stimuli (500ms), separated by variable memory delays (500ms, 2500ms, or 5000ms), were either identical sound presentations, i.e., match trials, or two different sound presentations, i.e., nonmatch trials. Sound stimuli were chosen semi-randomly from a large set sound set ( approximately 900). After reaching a criterion of 80% correct on the behavioral task, monkeys were injected with saline or doses of scopolamine hydrochloride mixed in saline (3 microg, 5 microg, and 10 microg per 1kg of weight), 30 min before training. Scopolamine impaired performance accuracy on match trials in a dose-dependent manner. Blocking muscarinic receptors with scopolamine did not significantly impair motor responses, food motivation, or responses to rewarded sound. These findings support the hypothesis that the cholinergic system is important for auditory short-term memory.

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confidence: 99%

Scopolamine impairs auditory delayed matching-to-sample performance in monkeys

Plakke

Poremba

2008

Neuroscience Letters

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“…In chapter 2, blocking ACh impaired performance on an auditory recognition/working memory task in a dose dependent manner. Analogous results have been found in multiple species, across a wide array of tasks, when using visual stimuli (Aigner & Mishkin, 1986;Aigner, Walker, & Mishkin, 1991;Elsmore et al, 1989;Flicker et al, 1990;Hironaka & Ando, 1996;Hudzik & Wenger, 1993;Myers et al, 2002;Ogura & Aigner, 1993;Penetar & McDonough, 1983;Pontecorvo, et al, 1991;Pontecorvo & Evans, 1985;Spinelli et al, 2006;Taffe et al, 1999). Chapter 3 investigated the specificity of the effect of blocking ACh by administering an ACh agonist (physostigmine) at the same time as an ACh antagonist (scopolamine).…”

Section: Auditory and Visual Working Memorymentioning

confidence: 74%

“…The use of acetylcholine for memory processing may be conserved across species as blocking it also impairs mainly visual memory performance in rats, pigeons, monkeys and humans (Elsmore et al, 1989;Flicker et al, 1990;Pontecorvo & Evans, 1985;Pontecorvo, et al, 1991;Hudzik & Wenger, 1993;Spinelli et al, 2006). For example, Pontecorvo et al, 1991 used mixed sensory stimuli using a light and tone as stimuli, and levers for responding in a delayed matching-to-sample task (DMTS); wherein rats had to remember which stimuli had been most recently administered and then choose the appropriate lever for matching and nonmatching trials.…”

Section: Dmts Performancementioning

confidence: 99%

Auditory working memory

Anderson¹,

Joy²

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Traditionally, working memory and its neural underpinnings have been studied in the visual domain. A rich and diverse amount of research has investigated the lateral prefrontal cortex (lPFC) as a primary area for visual working memory, while another line of research has found the neurotransmitter acetylcholine (ACh) to be involved. This dissertation used auditory cues and found similar patterns of activity for processing auditory working memory information within a task compared to visual working memory processes. The first two experimental chapters demonstrated that the cholinergic system is involved in auditory working memory in a comparable fashion to its role in visual working memory. In chapter 2, blocking ACh impaired performance on an auditory working memory task in a dose dependent manner. Chapter 3 investigated the specificity of the effect of blocking ACh by administering an ACh agonist (physostigmine) at the same time as an ACh antagonist (scopolamine). When both drugs were administered together performance on the delayed matching-to-sample task (DMTS) task improved compared to performance on scopolamine alone. These results support the hypothesis that ACh is involved in auditory working memory.Chapter 4 investigated the neural correlates of auditory working memory in area 46 and found that this region of the lPFC contains neurons that are responsive to auditory working memory components in a very similar way to how it this region encodes information during visual working memory tasks. Neurons in the lPFC are responsive to visual or auditory cues, the delay portion of tasks, the wait time (i.e. decision making period), response, and reward times. This type of coding provides support for the 2 theories that position the lPFC as a key player in recognition and working memory regardless of modality.Abstract Approved: _______________________________________________________ Thesis Supervisor _______________________________________________________

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Pharmacological studies of a rat spatial delayed nonmatch‐to‐sample task as an animal model of dementia

Deacon¹

1991

Drug Development Research

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Deacon, R.M.J.:Pharmacological studies of a rat spatial delayed nonmatch-to-sample task as an animal model of dementia. Drug Dev. Res. 24:67-79, 1991.A variation of the delayed nonmatch-to-sample task in rats has recently been described in which the spatial positions of retractable levers are used as the sample and response cues. The pharmacology of this task has been investigated, with the aim of developing models relevant to the search for compounds active in dementia, particularly Alzheimer's disease. Scopolamine and atropine decreased the accuracy of responding. This was attenuated by physostigmine and THA. Mecamylamine, 8-OH DPAT, CPP, MK-801, and pentobarbital all produced marked accuracy deficits. Diazepam and sodium valproate affected accuracy rather less. Subthreshold doses of mecamylamine and scopolamine given together produced a significant accuracy deficit. All the drugs tested decreased the total trials performed. Prior satiation experiments demonstrated that this rate decrease in itself did not necessarily cause the decrease in accuracy. CPP and MK-801 appeared to produce the largest decrease in accuracy, with the least effect on rate. This selectivity, combined with the emerging role of the NMDA receptor complex in learning, memory, and dementia, encourages the development of this model or similar models in the search for compounds with the potential to treat dementia.

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Atropine effects on delayed discrimination performance of rats

Cited by 10 publications

References 29 publications

Scopolamine impairs auditory delayed matching-to-sample performance in monkeys

Scopolamine impairs auditory delayed matching-to-sample performance in monkeys

Auditory working memory

Pharmacological studies of a rat spatial delayed nonmatch‐to‐sample task as an animal model of dementia

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