Atrial septal aneurysm and stroke

Background: The superior type of sinus venosus atrial septal defect (SVASD) is a rare form of the atrial septal defect (ASD) in which the upper part of the atrial septum does not exist. The presence of other cardiac anomalies such as anomalous pulmonary venous connections has been reported in this type of congenital heart disease. This study aimed to assess the presence of the patent foramen ovale (PFO) in patients with the superior type of SVASD. Methods: This retrospective case-control study on 387 patients, consisting of 187 patients with a definite SVASD and 200 patients with problems other than the ASD, was conducted in Rajaie Cardiovascular Medical and Research Center between February 2005 and July 2014. Seven patients with inadequate data were excluded from the analysis. The presence/absence of the PFO was also evaluated in the case and control groups. Results: The analyses were performed on 182 male and 198 female patients at a mean age of 39.07±14.41 and 51.01±15.80 years in the case and control groups, respectively. The PFO was significantly more frequent in the patients with the superior type of SVASD than in those without the condition (P<0.001). The persistence of the left superior vena cava was seen in 34 out of 180 patients with SVASD and in 1 out of 200 patients without the condition (18.9% vs 0.5%; P<0.001). Conclusion: This study was the first to highlight the coexistence of the PFO and the superior type of SVASD. Physiological, genetic, or fetal factors may play an important role in the association between the PFO and the SVASD.

show abstract

“…This type of aneurysm is associated with such cardiac abnormalities as the PFO, mitral valve prolapse, the ASD, and atrial arrhythmias. 26 - 28 …”

Section: Discussionmentioning

confidence: 99%

The Presence of Patent Foramen Ovale in the Superior Type of Sinus Venosus Atrial Septal Defect

Samiei

Akiash

Naeini

et al. 2020

JTHC

View full text Add to dashboard Cite

show abstract

“…В остальных клинических примерах [7][8][9][10][11] косвенно продемонстрировано самостоятельное влияние наличия АМПП на возникновение эмболических событий, хотя тромботические массы в аневризме напрямую не были визуализированы. Авторы объясняют это тем, что все другие известные источники эмболии были исключены.…”

Section: Discussionunclassified

Ischemic stroke on the background of probable in situ thrombosis of atrial septal aneurysm in a patient taking hormonal contraceptives

2020

View full text Add to dashboard Cite

Introduction. The independent role of the atrial septal aneurysm in the occurrence of ischemic stroke remains controversial. In addition to the mechanism of paradoxical embolism against the background of a patent foramen ovale associated with an aneurysm, a number of studies have demonstrated that ischemic stroke can develop due to in situ thrombosis in the aneurysm region.Materials and methods. Description of the clinical case of a patient with atrial septal aneurysm and ischemic stroke while taking hormonal contraceptives. Analyzed all available publications in PubMed on this topic.Results and discussion. Among publications suitable for the criteria, in addition to direct visualization of a blood clot in the area of the atrial septal aneurysm, its independent effect on the occurrence of embolic events was demonstrated. In all analyzed cases, anticoagulants were prescribed for secondary prevention, which is justified on the basis of the hypothesis of in situ thrombosis in the aneurysm region.Conclusion. The analysis of scientific publications showed that the knowledge of this problem is still extremely small. There are no clear criteria, in addition to direct visualization of a blood clot, allowing the atrial septal aneurysm to be considered as a direct cause of ischemic stroke. Nevertheless, the presence of this cardiac abnormality and in combination with risk factors or evidence of prothrombotic status make it possible to regard it as an independent cause of stroke, and qualify the stroke as cardioembolic, which justifies the advisability of prescribing anticoagulants for secondary prevention.

show abstract

“…Though usually benign, IASAs have been associated with cryptogenic stroke in younger patients (< 55 years). 3 , 4 They are thought to facilitate thrombus formation via stasis and provocation of atrial arrhythmias. IASAs are also highly associated with PFO, and the combination of the two lesions may increase stroke risk in a synergistic fashion.…”

Section: Discussionmentioning

confidence: 99%

From the Heart: Interatrial Septal Aneurysm Identified on Bedside Ultrasound

Butterfield¹,

Riguzzi²,

Frenkel³

et al. 2014

WestJEM

View full text Add to dashboard Cite

A 61 year-old man presented to the Emergency Department for one day of nonspecific chest pain. Bedside echocardiogram performed by the emergency physician revealed normal systolic cardiac function but also showed a large ( > 10mm) bicornuate interatrial septal aneurysm (IASA) projecting into the right atrium (Figure 1, Video 1). There was no evidence of intraatrial thrombus. A formal echocardiogram performed later that day confirmed the diagnosis and also detected a patent foramen ovale (PFO) with a left-to-right shunt that reversed with Valsalva maneuver.

show abstract

Atrial septal aneurysm and stroke

Cited by 13 publications

References 7 publications

The Presence of Patent Foramen Ovale in the Superior Type of Sinus Venosus Atrial Septal Defect

The Presence of Patent Foramen Ovale in the Superior Type of Sinus Venosus Atrial Septal Defect

Ischemic stroke on the background of probable in situ thrombosis of atrial septal aneurysm in a patient taking hormonal contraceptives

From the Heart: Interatrial Septal Aneurysm Identified on Bedside Ultrasound

Contact Info

Product

Resources

About