Atrial Remodeling in Atrial Fibrillation and Some Related MicroRNAs

Sharma, Deepak; Li, Guangping; Xu, Gang; Liu, Yuzhi; Xu, Yong

doi:10.1159/000334434

Cited by 20 publications

(18 citation statements)

References 184 publications

(123 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the present study, we found that the PD-1 -/group presented atrial electricity remodeling (shorter AERP and increased dAERP) and structural remodeling (atrial myocardial fibrosis). It is generally accepted that AF results from the presence of multiple reentrant circuits originating in the atria (23), and atrial remodeling increases the probability of generating multiple atrial wavelets by dispersion of refractoriness and rapid atrial activation (4). Our findings strongly suggest that the PD-1 -/mice are more likely to develop AF.…”

Section: Discussionsupporting

confidence: 57%

Programmed cell death-1 deficiency results in atrial remodeling in C57BL/6 mice

Cao

Lü

et al. 2012

International Journal of Molecular Medicine

View full text Add to dashboard Cite

Deficiency of the programmed cell death-1 (PD-1) gene enhances T-cell activation and increases inflammation levels. It has been reported that atrial fibrillation (AF) is closely related to inflammation. The aim of the present study was to investigate the role of PD-1 deficiency in the pathogenesis of AF. Two groups of mice were used in our experiment: the C57BL/6 and the C57BL/6-PD-(1-/-) group. The expression of the inflammatory cytokines interleukin (IL)-2, -4, -6, -10, -17, interferon-γ and tumor necrosis factor were detected. Furthermore, the levels of atrial myocyte oxidative stress, the atrial effective refractory period (AERP) and the atrial myocardial fibrosis levels were determined. Compared with the C57BL/6 group, we found that the inflammatory cytokines were significantly increased in the PD-1(-/-) group and the levels of atrial myocyte oxidative stress in the PD-1(-/-) group were also higher. The AERP became shorter and the dispersion of AERP was increased in the PD-1(-/-) group. Moreover, the PD-1(-/-) group presented significant atrial myocardial fibrosis but the C57BL/6 group did not. Our findings strongly suggest that the higher levels of inflammatory cytokines and atrial myocyte oxidative stress were present in the PD-1(-/-) mice and resulted in atrial electricity and structural remodeling. Due to the atrial remodeling, the PD-1(-/-) mice were more likely to develop AF.

show abstract

Section: Discussionsupporting

confidence: 57%

Programmed cell death-1 deficiency results in atrial remodeling in C57BL/6 mice

Cao

Lü

et al. 2012

International Journal of Molecular Medicine

View full text Add to dashboard Cite

show abstract

“…Particularly, the most frequently observed alterations regard increases in inward rectifier K + current (I K1 ) and reduction in inward L-type Ca 2+ current (I CaL ) (210). A shortening of the atrial effective refractory period (ERP), consequent to reduction of the action potential duration, and a loss of rate adaptation lead to arrhythmogenesis and AF (211). Several miRNAs are implicated in electrical remodeling (Table 5).…”

Section: Mirna In Atrial Fibrillationmentioning

confidence: 99%

microRNA in Cardiovascular Aging and Age-Related Cardiovascular Diseases

Lucia

Komici²,

Borghetti

et al. 2017

Front. Med.

View full text Add to dashboard Cite

Over the last decades, life expectancy has significantly increased although several chronic diseases persist in the population, with aging as the leading risk factor. Despite improvements in diagnosis and treatment, many elderlies suffer from cardiovascular problems that are much more frequent in an older, more fragile organism. In the long term, age-related cardiovascular diseases (CVDs) contribute to the decline of quality of life and ability to perform normal activities of daily living. microRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene expression at the posttranscriptional level in both physiological and pathological conditions. In this review, we will focus on the role of miRNAs in aging and age-related CVDs as heart failure, hypertension, atherosclerosis, atrial fibrillation, and diabetes mellitus. miRNAs are key regulators of complex biological mechanisms, representing an exciting potential therapeutic target in CVDs. Moreover, one major challenge in geriatric medicine is to find reliable biomarkers for diagnosis, prognosis, and prediction of the response to specific drugs. miRNAs represent a very promising tool due to their stability in the circulation and unique signature in CVDs. However, further studies are needed to investigate their translational potential in the real clinical practice.

show abstract

“…miRNA targeting pathways associated with the regulation of cardiomyocyte metabolism (miR-208a and miR-223) may alter the provision of energy substrate required to maintain AF [9–11], whereas other miRNAs are thought to play a central role in changes associated with structural (miR-133, miR-590, miR-29b, miR-208, miR-638 and miR-150) and electrical remodelling (miR-328, miR-1 and miR-26) [12]. However, much of the work to date examines miRNA expression in right or left atrial tissue and there remains a paucity of evidence surrounding circulating microRNA in human AF [13, 14].…”

Section: Introductionmentioning

confidence: 99%

Elevated serum microRNA 483-5p levels may predict patients at risk of post-operative atrial fibrillation

Harling

Lambert

Ashrafian

et al. 2016

Eur J Cardiothorac Surg

View full text Add to dashboard Cite

OBJECTIVESPost-operative atrial fibrillation (POAF) is the commonest post-operative cardiac arrhythmia, affecting ∼1 in 3 patients undergoing coronary artery bypass grafting (CABG). Although its aetiology is complex, atrial substrate changes may pre-dispose to its onset. This study aims to ascertain the atrial microRNA signature of POAF and determine the potential for circulating microRNA as a pre-operative biomarker for this arrhythmia.METHODSThirty-four patients undergoing non-emergent, on-pump CABG were prospectively recruited. Right atrial biopsies were taken intra-operatively and snap frozen for RNA extraction. Plasma was obtained at 24 h pre-operatively and at 2 and 4 days post-operatively. POAF was defined by continuous Holter recording. Inter-group comparisons were performed using Student's t-test or analysis of variance as required. Receiver operating characteristic (ROC) analysis was used to determine the diagnostic accuracy of pre-operative serum miRNA as a POAF biomarker.RESULTSSixteen microRNAs were differentially expressed in the atrial myocardium of POAF patients when compared with those maintaining sinus rhythm. miR-208a was the most underexpressed [fold change (FC) = 2.458] and miR-483-5p the most overexpressed (FC = 1.804). miR-483-5p also demonstrated significant overexpression in the pre-operative serum of these patients, with ROC analysis demonstrating an overall predictive accuracy of 78%.CONCLUSIONSThis study provides the first description of atrial myocardial and circulating plasma microRNA in POAF patients. Our findings suggest POAF may be associated with pre-existing atrial substrate differences predisposing to arrhythmogenesis. Moreover, this study highlights the potential for miR-483-5p in biomarker development. Further work must now perform prospective, targeted validation of these results in a larger patient cohort.

show abstract

Atrial Remodeling in Atrial Fibrillation and Some Related MicroRNAs

Cited by 20 publications

References 184 publications

Programmed cell death-1 deficiency results in atrial remodeling in C57BL/6 mice

Programmed cell death-1 deficiency results in atrial remodeling in C57BL/6 mice

microRNA in Cardiovascular Aging and Age-Related Cardiovascular Diseases

Elevated serum microRNA 483-5p levels may predict patients at risk of post-operative atrial fibrillation

Contact Info

Product

Resources

About