Atrial natriuretic peptide and urinary prostaglandins in man.

Benzoni, Daniel; Geoffroy, J; Waeber, Bernard; Hr, Brunner; Biollaz, J.; Sassard, J

doi:10.1111/j.1365-2125.1989.tb03518.x

Cited by 3 publications

(1 citation statement)

References 27 publications

(34 reference statements)

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“…Therefore, the observation that HOWI induces a significant increase in the natriuretic atrial plasma factor and urinary excretion of AQP2 in the absence of an increase in the plasma values of AVP, suggests that ANF may be a trigger for AQP2 expression, as already in part demonstrated by Patil et al [26]with AQP1 on Xenopus oocytes or the effect may be indirect, through the renal biosynthesis of prostaglandins (PGs) [27, 28]. In fact it has been observed in experimental conditions that immersion is followed by an increase in PG secretion, which reflects increased renal PG synthesis [29].…”

Section: Discussionmentioning

confidence: 94%

Water Immersion Increases Urinary Excretion of Aquaporin-2 in Healthy Humans

Buemi

Corica²,

Pasquale³

et al. 2000

Nephron

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Many previous studies have shown that aquaporin-2 (AQP2), the vasopressin-regulated water channel, is excreted in the urine and that the excretion increases in response to vasopressin. Moreover, recently a close correlation between AQP2 excretion in urine and kidney AQP2 expression has been demonstrated, showing that urinary excretion of AQP2 is a reliable indicator for AQP-2 function. As head-out water immersion causes an expansion in the central vascular volume equal to that induced by 2 liters of saline, without modifying plasma composition, we used immersion in water to evaluate if the response to acute expansion of the central vascular volume could involve vasporessin (AVP) and AQP2. In healthy subjects, concentrations of plasma atrial natriuretic factor (ANF) and AVP, and urinary AQP2 were measured during a 2-hour immersion period. In all subjects, immersion caused a prompt and marked increase in immunoreactive ANF (23.0 ± 2.12 pg/ml at second hour vs. 2.17 ± 0.42 pg/ml at baseline) and in urinary excretion of AQP2 (23.9 ± 2.69 pmol/mg creatinine at second hour vs. 4.42 ± 0.14 pmol/mg creatinine at baseline), while a significant decrease was found in plasma AVP. Recovery was associated with a prompt return to pre-study levels. These findings demonstrate that heat-out water immersion stimulates urinary excretion of AQP2 in absence of an increase in plasma AVP.

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Section: Discussionmentioning

confidence: 94%

Water Immersion Increases Urinary Excretion of Aquaporin-2 in Healthy Humans

Buemi

Corica²,

Pasquale³

et al. 2000

Nephron

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The renal excretory activity of atrial natriuretic factor is independent of renal prostaglandins in humans

Castellani¹,

Rosso²,

Chen³

et al. 1991

Prostaglandins, Leukotrienes and Essential Fatty Acids

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Nocturnal polyuria in monosymptomatic nocturnal enuresis refractory to desmopressin treatment

Kamperis¹,

Rittig²,

Jørgensen³

et al. 2006

American Journal of Physiology-Renal Physiology

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The transition from day to night is associated with a pronounced decline in diuresis with reductions in the amount of excreted water, electrolytes, and other end products of our metabolism. Failure to do so leads to a large urine output at night, a condition known as nocturnal polyuria, encountered in a large proportion of children with nocturnal enuresis. The aim of this study was to clarify the mechanisms responsible for the nocturnal polyuria seen in enuretics with inadequate response to desmopressin (dDAVP). Forty-six enuretics (7-14 yr of age) and fifteen age-matched controls were admitted for a 24-h protocol with standardized fluid and sodium intake, comprising urine collections, blood sampling, and blood pressure monitoring. We included patients with severe enuresis (5 +/- 1 wet nights/wk) showing <50% reduction in wet nights on dDAVP. We characterized the patients on the basis of their nocturnal urine production. The children with nocturnal polyuria excreted larger amounts of sodium and urea at night than nonpolyurics and controls. Solute-free water reabsorption as well as urinary arginine vasopressin and aquaporin-2 excretion were normal in polyurics, and no differences were found in atrial natriuretic peptide, angiotensin II, aldosterone, and renin levels. Urinary prostaglandin E2 (PGE2) excretion was significantly higher in polyurics. The nocturnal polyuria in children with dDAVP-resistant nocturnal enuresis seems to be the result of augmented sodium and urea excretion. The high urinary PGE2 levels found in these children point toward a role for increased prostaglandin synthesis in the pathogenesis of enuresis-related polyuria.

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Atrial natriuretic peptide and urinary prostaglandins in man.

Cited by 3 publications

References 27 publications

Water Immersion Increases Urinary Excretion of Aquaporin-2 in Healthy Humans

Water Immersion Increases Urinary Excretion of Aquaporin-2 in Healthy Humans

The renal excretory activity of atrial natriuretic factor is independent of renal prostaglandins in humans

Nocturnal polyuria in monosymptomatic nocturnal enuresis refractory to desmopressin treatment

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