Atrial Flutter Versus Atrial Fibrillation in a General Population: Differences in Comorbidities Associated With Their Respective Onset

Mareedu, Ravi K.; Abdalrahman, Ihab B.; Dharmashankar, Kodlipet; Granada, Juan F.; Chyou, Po‐Huang; Sharma, Param P.; Smith, Peter N.; Hayes, John J.; Greenlee, Robert T.; Vidaillet, Humberto

doi:10.3121/cmr.2009.851

Cited by 24 publications

(21 citation statements)

References 25 publications

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“…In contrast with AF, flutter compared to referents was not associated with body mass index, diabetes or hypertension. Our findings expand on previously reported flutter predictors from the Marshfield Epidemiologic Study Area 6,20 which found sex, HF and chronic pulmonary disease as risk factors for flutter and no association with diabetes or hypertension.…”

Section: Discussionsupporting

confidence: 86%

Atrial flutter: Clinical risk factors and adverse outcomes in the Framingham Heart Study

et al. 2016

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Background Few epidemiological cohort studies have evaluated atrial flutter (flutter) as an arrhythmia distinct from atrial fibrillation (AF). Objective To examine the clinical correlates of flutter and its associated outcomes to distinguish them from those associated with AF in the Framingham Heart Study. Methods We reviewed and adjudicated electrocardiograms previously classified as flutter or AF/flutter and another 100 electrocardiograms randomly selected from AF cases. We examined the clinical correlates of flutter by matching up to 5 AF and 5 referents to each flutter case using a nested case-referent design. We determined the 10-year outcomes associated with flutter with Cox models. Results During mean follow-up of 33.0±12.2 years, 112 participants (mean age 72±10 years, 30% women) developed flutter. In multivariable analyses, smoking (odds ratio [OR] 2.84; 95% confidence interval [CI], 1.54 to 5.23), increased PR interval (OR 1.28 per SD; 95% CI, 1.03 to 1.60), myocardial infarction (OR 2.25; 95% CI, 1.05 to 4.80) and heart failure (OR 5.22; 95% CI, 1.26 to 21.64) were associated with incident flutter. In age- and sex-adjusted models, flutter (vs. referents) was associated with 10-year increased risk of AF (hazard ratio [HR] 5.01; 95% CI, 3.14 to 7.99), myocardial infarction (HR 3.05; 95% CI, 1.42 to 6.59), heart failure (HR 4.14; 95% CI, 1.90 to 8.99), stroke (HR 2.17; 95% CI, 1.13 to 4.17), and mortality (HR 2.00; 95% CI, 1.44 to 2.79). Conclusions We identified the clinical correlates associated with flutter and observed that flutter was associated with multiple adverse outcomes.

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Section: Discussionsupporting

confidence: 86%

Atrial flutter: Clinical risk factors and adverse outcomes in the Framingham Heart Study

et al. 2016

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“…The mean age of AFL and AF cohorts were 70 and 72 years, respectively (P=NS). [54] Although many predisposing factors are shared between AFL and AF (with many patients affected by both arrhythmias), subjects with AFL without concurrent AF were more likely to have had a history of obstructive lung disease (25% vs 12%, P=0.006) and heart failure (28% vs 17%, P=0.05), while hypertension was more common (63% vs 47%, P=0.01) in the cohort with AF without concurrent AFL. [54]…”

Section: Tachyarrhythmiasmentioning

confidence: 99%

Epidemiology of Arrhythmias and Conduction Disorders in Older Adults

Chow

Marine

Fleg

2012

Clinics in Geriatric Medicine

131

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Normal aging is associated with a multitude of changes in the cardiovascular system, including decreased compliance of blood vessels, mild concentric left ventricular hypertrophy, an increased contribution of atrial contraction to left ventricular filling, and a higher incidence of many cardiac arrhythmias, both bradyarrhythmias and tachyarrhythmias. Conduction disorders also become more common with age, and may either be asymptomatic, or cause hemodynamic changes requiring treatment. The epidemiology of common arrhythmias and conduction disorders in the elderly is reviewed.

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“…Remark: Cerebral amyloid angiopathy should be diagnosed using validated clinico-radiological criteria. 39. In patients with AF and symptomatic carotid stenosis (> 50%), we suggest carotid revascularization with endarterectomy or stenting in addition to OAC as indicated (Weak recommendation, moderate quality evidence).…”

mentioning

confidence: 99%