Atrial fibrillation is independently associated with senile, vascular, and Alzheimer's dementia

Bunch, T. Jared; Weiss, J. Peter; Crandall, Brian G.; May, Heidi T.; Bair, Tami L; Osborn, Jeffrey S.; Anderson, Jeffrey L.; Muhlestein, Joseph B; Horne, Benjamin D.; Lappé, Donald; Day, John D.

doi:10.1016/j.hrthm.2009.12.004

Cited by 322 publications

(288 citation statements)

References 43 publications

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“…4 Coronary artery disease (CAD), peripheral arterial disease (PAD), chronic kidney disease, and low cardiac output have all been associated with cognitive impairment and dementia ( figure 1). An increased risk of VaD has been reported for CAD, 5 AF, 146 chronic kidney disease, 153 and PAD. 151 PAD and low cardiac output was furthermore found to be associated with AD.…”

Section: Concomitant Clinical Vascular Diseasementioning

confidence: 98%

Prevention of Vascular Cognitive Impairment

Dichgans

Zietemann²

2012

Stroke

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Section: Concomitant Clinical Vascular Diseasementioning

confidence: 98%

Prevention of Vascular Cognitive Impairment

Dichgans

Zietemann²

2012

Stroke

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“…Several different kinds of observational works-such as meta-analyses [12][13][14], reviews [15,16], and cross-sectional [17][18][19], cohort and longitudinal [20][21][22][23][24][25] studies-confirm an independent association between AF and cognitive decline at differing grades of severity.…”

Section: Introductionmentioning

confidence: 99%

Alteration of cerebrovascular haemodynamic patterns due to atrial fibrillation: an in silico investigation

Scarsoglio

Saglietto

Anselmino

et al. 2017

J. R. Soc. Interface.

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There has recently been growing evidence that atrial fibrillation (AF), the most common cardiac arrhythmia, is independently associated with the risk of dementia. This represents a very recent frontier with high social impact for the number of individuals involved and for the expected increase in AF incidence in the next 40 years. Although a number of potential haemodynamic processes, such as microembolisms, altered cerebral blood flow, hypoperfusion and microbleeds, arise as connecting links between the two pathologies, the causal mechanisms are far from clear. An in silico approach is proposed that combines in sequence two lumped-parameter schemes, for the cardiovascular system and the cerebral circulation. The systemic arterial pressure is obtained from the cardiovascular system and used as the input for the cerebral circulation, with the aim of studying the role of AF on the cerebral haemodynamics with respect to normal sinus rhythm (NSR), over a 5000 beat recording. In particular, the alteration of the haemodynamic (pressure and flow rate) patterns in the microcirculation during AF is analysed by means of different statistical tools, from correlation coefficients to autocorrelation functions, crossing times, extreme values analysis and multivariate linear regression models. A remarkable signal alteration, such as a reduction in signal correlation (NSR, about 3 s; AF, less than 1 s) and increased probability (up to three to four times higher in AF than in NSR) of extreme value events, emerges for the peripheral brain circulation. The described scenario offers a number of plausible cause-effect mechanisms that might explain the occurrence of critical events and the haemodynamic links relating to AF and dementia.

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“…12 Although a higher prevalence of dementia in patients with AF and without a history of stroke or transient ischemic attack suggests that silent thromboembolism may have long-term ramifications, 13 the significance of silent cerebral embolism detected by MRI the day after a catheter ablation procedure is uncertain. Although thrombus is the likely offender, air or tissue fragments may also embolize.…”

Section: Article See P 1667mentioning

confidence: 99%

Silent Cerebral Embolism During Catheter Ablation of Atrial Fibrillation

Michaud

2010

Circulation

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Atrial fibrillation is independently associated with senile, vascular, and Alzheimer's dementia

Cited by 322 publications

References 43 publications

Prevention of Vascular Cognitive Impairment

Prevention of Vascular Cognitive Impairment

Alteration of cerebrovascular haemodynamic patterns due to atrial fibrillation: an in silico investigation

Silent Cerebral Embolism During Catheter Ablation of Atrial Fibrillation

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