Atrial fibrillation in obstructive sleep apnea

Goyal, Sandeep; Sharma, Abhishek

doi:10.4330/wjc.v5.i6.157

Cited by 47 publications

(48 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Polymorphisms in ARDB1 are associated with differences in resting hemodynamics and response to positive airway pressure therapy in those with OSA 21,22 and also track with a higher prevalence of OSA in hypertensive individuals. 23 Our findings provide additional support for a link between OSA and ADRB1 polymorphisms.…”

Section: Discussionmentioning

confidence: 99%

Severity of Obstructive Sleep Apnea Influences the Effect of Genotype on Response to Anti-Arrhythmic Drug Therapy for Atrial Fibrillation

Goyal¹,

Wang²,

Upender

et al. 2014

Journal of Clinical Sleep Medicine

View full text Add to dashboard Cite

Study Objectives: To examine the impact of genotype on the relationship between obstructive sleep apnea (OSA) and antiarrhythmic drug (AAD) effi cacy in atrial fi brillation (AF). Design: Registry based. Setting: Clinic-based. Participants: Eighty-four individuals from Vanderbilt AF registry who had polysomnography, genotyping, and serial comprehensive evaluations of AF status. Interventions: None. Measurements and Results: Response to AADs was defi ned as a decrease in AF burden score by ≥ 75% or the combination of sinus rhythm on follow-up EKGs, stable AAD therapy for at least 6 months, objective AF burden below an established threshold, and the absence of non-pharmacologic therapies. Participants were genotyped for common AF susceptibility alleles at chromosomes 4q25 (near PITX2), 16q22 (in ZFHX3), and 1q21 (in KCNN3), and common SNPs in the β1-adrenergic receptor (ARDB1). Wild-type status for rs10033464 at 4q25 was associated with increased success of AAD therapy in patients with no or mild OSA (odds ratio: 10.0, 95% confi dence interval: 1.03 to 97.5; p < 0.05), but did not infl uence response to AAD therapy in those with moderate-severe OSA. A similar trend was observed for rs1801252 on ARDB1. Conclusion:In this hypothesis-generating pilot study of predominantly Caucasian men, the effect on AF response to AAD therapy of rs10033464 at 4q25 varied based on OSA status. The impact of genotype on AAD effi cacy may be greatest in mild OSA and attenuated in more severe disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Severity of Obstructive Sleep Apnea Influences the Effect of Genotype on Response to Anti-Arrhythmic Drug Therapy for Atrial Fibrillation

Goyal¹,

Wang²,

Upender

et al. 2014

Journal of Clinical Sleep Medicine

View full text Add to dashboard Cite

show abstract

“…Entre las investigaciones realizadas posteriormente, se destaca una cohorte del SHHS, en la que se observó que los pacientes con SAHOS tenían un riesgo relativo indirecto de 4,0 de sufrir fibrilación auricular 43 .…”

Section: Arritmias Cardíacasunclassified

Síndrome de apnea/hipopnea obstructiva del sueño y su asociación con las enfermedades cardiovasculares

Barashi¹,

Ruíz²,

Marín³

et al. 2015

Revista Colombiana de Cardiología

View full text Add to dashboard Cite

Recibido el 3 de abril de 2014; aceptado el 4 de agosto de 2014 Disponible en Internet el 21 de abril de 2015 PALABRAS CLAVE Sueño; Factores de riesgo cardiovascular; Enfermedades cardiovasculares; Síndrome metabólico ResumenIntroducción: El síndrome de apnea/hipopnea obstructiva del sueño, es una entidad que ha cobrado importancia en los últimos años, con una prevalencia estimada en adultos de edad media cercana al 4 y al 2% en hombres y mujeres, respectivamente, y que por su frecuencia constituye un problema de salud pública. Objetivo: Exponer, tras un análisis exhaustivo de la literatura disponible, la asociación entre el síndrome de apnea/hipopnea obstructiva del sueño y las enfermedades cardiovasculares. Método: Se hizo una revisión narrativa a partir de la literatura encontrada en las bases de datos más reconocidas. Se incluyeron 59 estudios publicados en los últimos treinta años y se excluyeron reportes y series de casos. Conclusiones: El síndrome de apnea/hipopnea obstructiva del sueño se reconoce hoy en día como un problema de salud pública mundial. En Latinoamérica, más específicamente en Colombia, se requieren estudios prospectivos de cohorte que sirvan de pauta para la población del continente e indiquen posibles diferencias respecto a la comunidad internacional en cuanto a su tratamiento y diagnóstico oportunos, así como acerca del impacto de estos en lo concerniente a los desenlaces cardiovasculares de los pacientes.

show abstract

“…The growing prevalence of obesity and the increasing population body mass index has created major public health challenges [11] . Obstructive sleep apnea has been independently linked with hypertension, atrial fibrillation, cardiac disease, worsening of diabetes, insulin resistance, peri-operative and postoperative complications and coronary artery disease (CAD), to name the few [12][13][14][15][16] .…”

Section: Obstructive Sleep Apneamentioning

confidence: 99%

Diabetes, sleep apnea, obesity and cardiovascular disease: Why not address them together?

Surani

2014

WJD

View full text Add to dashboard Cite

Obesity, sleep apnea, diabetes and cardiovascular diseases are some of the most common diseases encountered by the worldwide population, with high social and economic burdens. Significant emphasis has been placed on obtaining blood pressure, body mass index, and placing importance on screening for signs and symptoms pointing towards cardiovascular disease. Symptoms related to sleep, or screening for sleep apnea has been overlooked by cardiac, diabetic, pulmonary and general medicine clinics despite recommendations for screening by several societies. In recent years, there is mounting data where obesity and obstructive sleep apnea sit at the epicenter and its control can lead to improvement and prevention of diabetes and cardiovascular complications. This editorial raises questions as to why obstructive sleep apnea screening should be included as yet another vital sign during patient initial inpatient or outpatient visit.

show abstract

Atrial fibrillation in obstructive sleep apnea

Cited by 47 publications

References 67 publications

Severity of Obstructive Sleep Apnea Influences the Effect of Genotype on Response to Anti-Arrhythmic Drug Therapy for Atrial Fibrillation

Severity of Obstructive Sleep Apnea Influences the Effect of Genotype on Response to Anti-Arrhythmic Drug Therapy for Atrial Fibrillation

Síndrome de apnea/hipopnea obstructiva del sueño y su asociación con las enfermedades cardiovasculares

Diabetes, sleep apnea, obesity and cardiovascular disease: Why not address them together?

Contact Info

Product

Resources

About