Atractyloside and 5-hydroxydecanoate block the protective effect of puerarin in isolated rat heart

Gao, Qin; Pan, Hongyang; Qiu, Shuang; Lü, Yuan; Bruce, Iain C.; Luo, Jianhong; Xia, Qiang

doi:10.1016/j.lfs.2005.12.040

Cited by 39 publications

(31 citation statements)

References 25 publications

(28 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The protective effect was attenuated by the administration of 5-hydroxydecanoate (100 mol/L, mitochondrial-specific ATP-sensitive potassium channel antagonist) and atractyloside (20 mol/L, mitochondrial permeability transition pore opener). Indeed, pretreatment of puerarin in isolated cardiac myocytes noticeably prevented ischaemia-induced cell death (49.2 ± 3.4%) and depolarisation of the mitochondrial membrane (Gao et al, 2006). In an in vitro study, administration of paxillin (1 mol/L, calcium-activated potassium channel) deprived the cardioprotective effect of puerarin in isolated rat hearts.…”

Section: Anti-ischaemiamentioning

confidence: 95%

Kudzu root: Traditional uses and potential medicinal benefits in diabetes and cardiovascular diseases

Wong

et al. 2011

Journal of Ethnopharmacology

312

212

View full text Add to dashboard Cite

Section: Anti-ischaemiamentioning

confidence: 95%

Kudzu root: Traditional uses and potential medicinal benefits in diabetes and cardiovascular diseases

Wong

et al. 2011

Journal of Ethnopharmacology

312

212

View full text Add to dashboard Cite

“…At the beginning of perfusion, the left ventricular end-diastolic pressure (LVEDP) was adjusted to 4-8 mm Hg. 28 The heart was allowed to equilibrate for 20 minutes and then was subjected to global ischemia for 30 minutes and reperfusion for 120 minutes. 28 Left ventricular developed pressure, LVEDP, heart rate, and rate pressure product (RPP = left ventricular developed pressure · heart rate) were monitored throughout the experimental period.…”

Section: Preparation Of I/r Model In Isolated Rat Heartmentioning

confidence: 99%

Cardioprotective Effects of Luteolin on Ischemia/Reperfusion Injury in Diabetic Rats Are Modulated by eNOS and the Mitochondrial Permeability Transition Pathway

Yang

Qian

Zhang

et al. 2015

Journal of Cardiovascular Pharmacology

View full text Add to dashboard Cite

Myocardial ischemia/reperfusion (I/R) injury in diabetes is associated with oxidative stress, endothelial nitric oxide synthase (eNOS) dysfunction, and mitochondrial collapse, whereas luteolin is known to protect the cardiovascular system against diabetes and I/R injury. Here, we investigated whether luteolin pretreatment diminishes myocardial I/R injury in diabetic rats by affecting eNOS and the mitochondrial permeability transition pore (mPTP). After diabetic rats were produced by streptozotocin treatment (65 mg/kg) for 3 weeks, luteolin (100 mg·kg·d) or L-NAME (25 mg·kg·d) was administered intragastrically for 2 weeks. Hearts were then isolated and subjected to 30 minutes of global ischemia followed by 120 minutes of reperfusion. Pretreatment with luteolin significantly improved left ventricular function and coronary flow throughout reperfusion, increased cardiac tissue viability and manganese superoxide dismutase (MnSOD) activity, and reduced coronary lactate dehydrogenase release, and the myocardial malonaldehyde level in diabetic I/R rat hearts. All these improving effects of luteolin were significantly attenuated by L-NAME. Luteolin also significantly upregulated eNOS expression in diabetic rat hearts after I/R. Ca-induced mPTP opening and mitochondrial inner membrane potential reduction were significantly inhibited in ventricular myocytes isolated from luteolin-treated diabetic rats, and this effect was attenuated by L-NAME. These findings indicate that luteolin protects the diabetic heart against I/R injury by upregulating the myocardial eNOS pathway, and downstream effects include the enhancement of MnSOD and inhibition of mPTP.

show abstract

“…Lorenz et al found that the green tea component EGCG activates cardiac Na + /H + and Na + /Ca 2+ exchangers, thereby modulating myocardial contractility [89]. The multichannel inhibitor puerarin has been shown to also inhibit the mitochondrial permeability transition pore opening and activate the mitochondrial ATP-sensitive potassium channel, thereby possibly reducing ischemia and reperfusion injury [90].…”

Section: Miscellaneous Effectsmentioning

confidence: 99%

Cardiovascular Ion Channels as a Molecular Target of Flavonoids

Scholz

Zitron

Katus

et al. 2010

Cardiovascular Therapeutics

View full text Add to dashboard Cite

SUMMARYFlavonoids are a class of naturally occurring polyphenols abundant in edibles and beverages of plant origin. Epidemiological studies consistently associate high flavonoid intake with a reduced risk for the development of cardiovascular diseases. So far these beneficial effects have been mainly attributed to nonspecific antioxidant and antiinflammatory properties. However, there is an increasing body of evidence that flavonoids specifically target molecular structures including cardiovascular ion channels. Playing a pivotal role in the regulation of vascular tone and cardiac electric activity, ion channels represent a major target for the induction of antihypertensive and cardioprotective effects. Thus, pharmacological properties of flavonoids on cardiovascular ion channels, ion currents and tissue preparations are being increasingly addressed in experimental studies. Whereas it has become clear that cardiovascular ion channels represent an important molecular target of flavonoids, the published data have not yet been systematically reviewed.

show abstract

Atractyloside and 5-hydroxydecanoate block the protective effect of puerarin in isolated rat heart

Cited by 39 publications

References 25 publications

Kudzu root: Traditional uses and potential medicinal benefits in diabetes and cardiovascular diseases

Kudzu root: Traditional uses and potential medicinal benefits in diabetes and cardiovascular diseases

Cardioprotective Effects of Luteolin on Ischemia/Reperfusion Injury in Diabetic Rats Are Modulated by eNOS and the Mitochondrial Permeability Transition Pathway

Cardiovascular Ion Channels as a Molecular Target of Flavonoids

Contact Info

Product

Resources

About