Atractylone in the Atractylodes macrocephala Rhizoma Essential Oil and Its Anti-Inflammatory Activity

Li, Ling; He, Yihao; Wang, Nan; Li, Yuting; Du, Yaoyao; He, Ning; Wang, Bing; Zhang, Tong

doi:10.3390/molecules28217340

Cited by 3 publications

(1 citation statement)

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“…Tang T J et al [20] reported that glycyrrhizin can promote AMPK phosphorylation and SIRT1 protein expression and inhibit the phosphorylation of nuclear factor NF-κB p65 to protect H9c2 cells from H 2 O 2 -induced cell damage. Li L et al [21] reported that Atractylodes inhibited the expression of pro-inflammatory cytokines such as IL-6 and TNF-α and down-regulated the PI3K-AKT signaling pathway, thereby helping to enhance the repair of intestinal epithelial barrier function and alleviate colon damage in mouse colitis models. Shi K et al [22] reported that Atractylodes lancea rhizome attenuates oxidative stress and inflammation through the TLR4/NF-κB and Keap1/Nrf2 signaling pathways, thereby alleviating LPS-induced acute lung injury.…”

Section: Introductionmentioning

confidence: 99%

Effects of Crude Extract of Glycyrrhiza Radix and Atractylodes macrocephala on Immune and Antioxidant Capacity of SPF White Leghorn Chickens in an Oxidative Stress Model

Zhang,

Wang,

Han

et al. 2024

Antioxidants

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The natural edible characteristics of Chinese herbs have led more and more people to study them as an alternative product to antibiotics. In this study, crude extracts of Glycyrrhiza radix and Atractylodes macrocephala (abbreviated as GRAM) with glycyrrhizic acid content not less than 0.2 mg/g were selected to evaluate the effects of GRAM on the immune and antioxidant capacity of model animals. Thirty 21-day-old male Leghorn chickens were weighed and randomly assigned to one of three groups of ten animals each. The treatments comprised a control group (CON), in which saline was injected at day 31, day 33, and day 35, an LPS-treated group (LPS), in which LPS (0.5 mg/kg of BW) was injected at day 31, day 33, and day 35, and finally a GRAM and LPS-treated group, (G-L) in which a GRAM-treated diet (at GRAM 2 g/kg) was fed from day 21 to day 35 with LPS injection (0.5 mg/kg of BW) at day 31, day 33, and day 35. The results of diarrhea grade and serum antioxidant measurement showed that the LPS group had obvious diarrhea symptoms, serum ROS and MDA were significantly increased, and T-AOC was significantly decreased. The oxidative stress model of LPS was successfully established. The results of immune and antioxidant indexes showed that feeding GRAM significantly decreased levels of the pro-inflammatory factors TNF-α, IL-1β, and IL-6 (p < 0.05) and significantly increased levels of the anti-inflammatory factors IL-4 and IL-10 and levels of the antioxidant enzymes GSH-Px and CAT (p < 0.05). GRAM resisted the influence of LPS on ileum morphology, liver, and immune organs and maintained normal index values for ileum morphology, liver, and immune organs. In summary, this study confirmed the antidiarrheal effect of GRAM, which improved the immune and antioxidant capacity of model animals by regulating inflammatory cytokine levels and antioxidant enzyme activity in poultry.

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Section: Introductionmentioning

confidence: 99%