A comprehensive pharmacological review of Atractylodes Macrocephala: Traditional uses, phytochemistry, pharmacokinetics, and therapeutic potential

Singh, Kuldeep; Singh, Geetanjali; Bhushan, Bharat; Kumar, Shivendra; Dhurandhar, Yogita; Dixit, Prakhar

doi:10.1016/j.prmcm.2024.100394

Pharmacological Research - Modern Chinese Medicine

2024

DOI: 10.1016/j.prmcm.2024.100394

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A comprehensive pharmacological review of Atractylodes Macrocephala: Traditional uses, phytochemistry, pharmacokinetics, and therapeutic potential

Kuldeep Singh,

Geetanjali Singh,

Bharat Bhushan

et al.

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Cited by 3 publications

References 47 publications

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Exploring the ancient wisdom and modern relevance of Chinese medicine: A comprehensive review

Singh,

Gupta,

Jain

et al. 2024

Pharmacological Research - Modern Chinese Medicine

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Exploring the ancient wisdom and modern relevance of Chinese medicine: A comprehensive review

Singh,

Gupta,

Jain

et al. 2024

Pharmacological Research - Modern Chinese Medicine

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Enhancement of Rhizoma Atractylodis Quality, Soil Nutrients, and Microbial Characters of Vermicompost Preparations from Spent Mushroom and Cow Dung

Sun,

Wang,

Zhang

et al. 2024

Agronomy

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Organic fertilizers produced from agricultural waste materials using earthworms have many advantages. The impact of vermicompost bio-organic fertilizer (VcF) prepared from waste mushroom bran on the quality of Chinese herbal medicine and soil health deserves attention. We conducted a field experiment to explore the quality of Rhizoma atractylodis and soil, using chemical fertilizer and VcF at dosages of 30 t·ha−1 and 40 t·ha−1. The results demonstrated that VcF significantly increased the contents of atractylenolide II, β-eudesmol, atractylenol, and atractylenolone by 34%, 175%, 72%, and 24%, respectively, along with a 70% increase in yield compared to the control. VcF significantly increased the available phosphorus content and the activity of the soil enzymes (α-Galactosidase, β-Galactosidase, and peroxidase), while reducing the nitrate nitrogen content. The addition of vermicompost did not change the soil bacterial diversity, while it significantly increased the soil fungal diversity. VcF improved the soil fungal diversity and significantly enhanced the relative abundance of the bacterial phylum Actinobacteriota and WPS-2, as well as the fungal phylum Ascomycota. Vermicompost significantly increased the relative abundance of bacteria phylum Actinobacteriota and WPS-2, as well as the fungi phylum Ascomycota. Actinobacteria mainly participate in the decomposition of detritus and the heterotrophic nutrient cycle. A Principal Coordinates Analysis of the soil bacterial and fungi communities suggested a significant impact of vermicompost application on the community structure of the soil bacteria. Conversely, no significant variance was detected in the bacterial community composition across the two levels of vermicompost. This study contributes to the enhancement of fertilization strategies for Atractylodes macrocephala, broadens the application scope of vermicompost, and advances the growth of organic agriculture.

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Phytochemical Composition and Bioactivities of Some Hydrophytes: Antioxidant, Antiparasitic, Antibacterial, and Anticancer Properties and Mechanisms

Alharthi,

Althagafi,

Jafri

et al. 2024

Plants

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Few researches have explored the production of pharmaceuticals from aquatic plants. Therefore, this study explored, for the first time, the phytochemical composition and bioactivities of ten aquatic plants. Aquatic plant shoots from various Nile River canals were collected, dried, and ground for aqueous extract preparation. Phytochemical composition and antioxidant capacity were assessed using DPPH assays. Extracts were tested for antiparasitic, antibacterial, anti-biofilm, and anticancer activities through standard in vitro assays, measuring IC50 values, and evaluating mechanisms of action, including cell viability and high-content screening assays. The results showed that the aquatic plants were rich in pharmaceutical compounds. The antioxidant capacity of these extracts exceeded that of vitamin C. The extracts showed promising antiparasitic activity against pathogens like Opisthorchis viverrini and Plasmodium falciparum, with IC50 values between 0.7 and 2.5 µg/mL. They also demonstrated low MICs against various pathogenic bacteria, causing DNA damage, increased plasma membrane permeability, and 90% biofilm inhibition. In terms of anticancer activity, extracts were effective against a panel of cancer cell lines, with Ludwigia stolonifera exhibiting the highest efficacy. Its IC50 ranged from 0.5 µg/mL for pancreatic, esophageal, and colon cancer cells to 1.5 µg/mL for gastric cancer cells. Overall, IC50 values for all extracts were below 6 µg/mL, showing significant apoptotic activity, increased nuclear intensity, plasma membrane permeability, mitochondrial membrane permeability, and cytochrome c release, and outperforming doxorubicin. This study highlights the potential of aquatic plants as sources for new, safe, and effective drugs with strong antiparasitic, antibacterial, and anticancer properties.

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A comprehensive pharmacological review of Atractylodes Macrocephala: Traditional uses, phytochemistry, pharmacokinetics, and therapeutic potential

Cited by 3 publications

References 47 publications

Exploring the ancient wisdom and modern relevance of Chinese medicine: A comprehensive review

Exploring the ancient wisdom and modern relevance of Chinese medicine: A comprehensive review

Enhancement of Rhizoma Atractylodis Quality, Soil Nutrients, and Microbial Characters of Vermicompost Preparations from Spent Mushroom and Cow Dung

Phytochemical Composition and Bioactivities of Some Hydrophytes: Antioxidant, Antiparasitic, Antibacterial, and Anticancer Properties and Mechanisms

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