Atractylenolides, essential components of Atractylodes-based traditional herbal medicines: Antioxidant, anti-inflammatory and anticancer properties

Bailly, Christian

doi:10.1016/j.ejphar.2020.173735

Cited by 49 publications

(36 citation statements)

References 159 publications

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“…Sesquiterpenoids including hinesol, βeudesmol, atractylon, elemol, guaiol, β-caryophyllene, and (5R,7R,10S)−3-hydroxylisopterocarpolo-ne-3-O-βsesquiterpenoids [7,8], as well as polyacetylenes including atractylodin, (6E,12E)-tetradeca-6,12-dien-8,10-diyne-1,3diol, and (1,3Z,11E)-tridecatriene-7,9-diyne-5-hydroxyl-6-O-β-glucopyranoside [9,10], have been isolated. The pharmacological activities of A. lancea include antiangiogenic, antioxidant, anti-inflammatory, anti-cancer, and anti-ulcer effects, as well as the inhibition of gastric acid secretion [11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Comparative analysis in different organs and tissue‐specific metabolite profiling of Atractylodes lancea from four regions by GC–MS and laser microdissection

et al. 2022

J of Separation Science

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Traditional Chinese medicine is made from the rhizome of Atractylodes lancea (Thunb.) DC. (Compositae), known as Cangzhu. In this study, gas chromatography‐mass spectrometry was used to identify and quantify the volatile oils of different organs of A. lancea from four regions of China: Jiangsu, Anhui, Henan, and Hubei provinces. The volatile oils of A. lancea were qualitatively and quantitatively characterized using gas chromatography‐mass spectrometry combined with laser microdissection. The results identified 21 components in A. lancea, the majority of the components were found in the rhizomes, followed by the fibrous roots, flowers, leaves, and stems. According to the contents of volatile oils in A. lancea, it was divided into Dabieshan (mainly includes hinesol and β‐eudesmol) and Maoshan types (mainly includes atractylon and atractylodin), and the ratios of hinesol:β‐eudesmol:atractylon:atractylodin were 17.06:4.55:0:1, 12.66:11.71:0.99:1, 7.43:6.23:0:1, and 0.13:0.16:1.52:1 in A. lancea from AH, HN, HB, and JS, respectively. Tissue‐specific study indicated that Dabieshan type mainly includes elemol, hinesol, and β‐eudesmol in the periderm and secretory cavities of A. lancea, whereas Maoshan type mainly includes atractylon, atractylodin, little hinesol, and β‐eudesmol in the secretory cavities. Conversely, no volatile oils were detected in the cortex, phloem, xylem, vascular ray, or pith. This study provides a foundation for further evaluation and utilization of A. lancea.

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Section: Introductionmentioning

confidence: 99%

Comparative analysis in different organs and tissue‐specific metabolite profiling of Atractylodes lancea from four regions by GC–MS and laser microdissection

et al. 2022

J of Separation Science

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“…Atractylenolides, isolated from the rhizomes of Atractylodes species, as well as Mist Antiaris, a monoherbal decoction prepared from the stem bark of Antiaris Africana , could be examples of such agents. The former two has been observed to possess neuroprotective, antioxidative and anti-inflammatory traits, thus making them a potentially interesting option to be reviewed in the future [ 165 ]. The effects of the latter are less understood, nevertheless it has been observed to alleviate symptoms of neuropathy [ 166 ].…”

Section: Discussionmentioning

confidence: 99%

Dietary Supplements in Chemotherapy-Induced Peripheral Neuropathy: A New Hope?

Szklener

Michalski

et al. 2022

Nutrients

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Chemotherapy-induced peripheral neuropathy (CIPN) is one of the main and most prevalent side effects of chemotherapy, significantly affecting the quality of life of patients and the course of chemotherapeutic treatment. Nevertheless, despite its prevalence, the management of the CIPN is considered particularly challenging, with this condition often being perceived as very difficult or even impossible to prevent with currently available agents. Therefore, it is imperative to find better options for patients diagnosed with this condition. While the search for the new agents must continue, another opportunity should be taken into consideration—repurposing of the already known medications. As proposed, acetyl-L-carnitine, vitamins (group B and E), extracts of medical plants, including goshajinkigan, curcumin and others, unsaturated fatty acids, as well as the diet composed of so-called “sirtuin-activating foods”, could change the typical way of treatment of CIPN, improve the quality of life of patients and maintain the continuity of chemotherapy. This review summarizes currently available data regarding mentioned above agents and evaluates the rationale behind future research focused on their efficacy in CIPN.

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“…For example, it was reported that the proteins in R isatidis could eliminate the damage of free radicals, showing a strong antioxidant effect in vivo ( Xiao et al, 2019 ). Furthermore, ingredients, such as white peony polyphenols, isolated from R. paeoniae alba ( Zhou et al, 2019 ) and atractylenolides isolated from Atractylodes macrocephalae ( Bailly, 2020 ) are also effective antioxidants. Studies have shown that polysaccharides from Codonopsis pilosula can protect the intestinal mucosal immune barrier, potentially maintaining the intestinal microbiota by stimulating the growth of Lactobacillus ( Fu et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that the extract of R. isatidis showed the antioxidant and anti-inflammatory effects in vitro ( Xiao et al, 2014 ). As the active ingredients of Atractylodes macrocephala , Atractylenolides contain the antioxidant and anti-inflammatory properties ( Bailly, 2020 ). Studies have shown that R. paeoniae alba contains a large number of pharmacological properties including anti-inflammatory, antioxidation, improving immunity ( Li et al, 2011 ; Su-Hong et al, 2015 ), and hepatoprotective effect ( Zhao et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Mixture of Five Fermented Herbs (Zhihuasi Tk) Alters the Intestinal Microbiota and Promotes the Growth Performance in Piglets

Sun

Hong

et al. 2021

Front. Microbiol.

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To explore the feasibility of using fermented Chinese herbal mixture Zhihuasi Tk (Z. Tk) supplementation to increase the swine production, the protective effect of dietary supplementation with Z. Tk on the intestinal oxidative stress model and the regulation of both growth performance and intestinal microbiota of weaned piglets were investigated in vitro. Our results showed that the addition of Z. Tk increased the cell viability, prevented the decrease of glutathione peroxidase, and significantly increased the total antioxidant capacity and reduced the damage caused by H2O2 to the tight junction proteins of the porcine small intestinal epithelial cell line (IPEC-J2). Furthermore, weaned piglets supplemented with either 2 kg/ton zinc oxide (ZnO) or 4 kg/ton of Z. Tk in the diet increased body weight as well as average daily feed intake and daily gain, while the feed conversion rate and diarrhea rate decreased within 0–35 days. Results of the taxonomic structure of the intestinal microbiota showed that, in 21 days after weaning, the Firmicutes/Bacteroidetes ratio in experimental group was increased, while the abundance of beneficial bacteria such, as Lactobacillus, was increased by Z. Tk, showing inhibitory effect on pathogenic bacteria such as members of Proteobacteria. In summary, dietary supplementation with Z. Tk maintained the intestinal microbiota in a favorable state for the host to effectively reduce the abnormal changes in the intestinal microbial structure and improved growth performance of weaned piglets. Therefore, Z. Tk may potentially function as a substitute for ZnO in feed additives for weaned piglets in modern husbandry.

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Atractylenolides, essential components of Atractylodes-based traditional herbal medicines: Antioxidant, anti-inflammatory and anticancer properties

Cited by 49 publications

References 159 publications

Comparative analysis in different organs and tissue‐specific metabolite profiling of Atractylodes lancea from four regions by GC–MS and laser microdissection

Comparative analysis in different organs and tissue‐specific metabolite profiling of Atractylodes lancea from four regions by GC–MS and laser microdissection

Dietary Supplements in Chemotherapy-Induced Peripheral Neuropathy: A New Hope?

Mixture of Five Fermented Herbs (Zhihuasi Tk) Alters the Intestinal Microbiota and Promotes the Growth Performance in Piglets

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