“…Swelling-induced adenosine triphosphate (ATP) release has been widely reported in different cell types (Wang et al, 1996;Roman et al, 1999a,b;Sabirov et al, 2001;Shinozuka et al, 2001;Boudreault and Grygorczyk, 2002;Hisadome et al, 2002;Jans et al, 2002;Darby et al, 2003;van der Wijk et al, 2003;Evanko et al, 2004;Gatof et al, 2004;Ito et al, 2004;Ollivier et al, 2006), as well as in in vivo studies in rat cerebral cortex (Phillis and O'Regan, 2002;Phillis, 2004). However, controversy still exists about the mechanism of its release, which has been reported mediated by either exocytosis (Boudreault and Grygorczyk, 2002;van der Wijk et al, 2003;Gatof et al, 2004), a transporter (Roman et al, 1997;Braunstein et al, 2001Braunstein et al, , 2004Darby et al, 2003;Reigada and Mitchell, 2005), or a channel (Wang et al, 1996;Roman et al, 1999a;Sabirov et al, 2001;Hisadome et al, 2002;Ito et al, 2004;Okada et al, 2004;Sabirov and Okada, 2004).…”