Atorvastatina Atenua o Remodelamento Vascular em Camundongos com Síndrome Metabólica

Carvalho, Karine Ferreira da Silva; Ferreira, Amanda Araújo Marques; Barbosa, Nayara Carvalho; Alves, Juliano; Costa, Rafael Menezes da

doi:10.36660/abc.20200322

Cited by 4 publications

(1 citation statement)

References 58 publications

(71 reference statements)

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“…Statins also reduced the levels of inflammatory biomarkershigh-sensitivity C reactive protein, interleukin-6, interleukin-8, and sCD14 and the secretion of monocyte chemoattractant protein-1. It led to a decreased recruitment of leukocytes during inflammation, which was associated with a decrease in the content of remodeling markers as well as with a significant decrease in metabolic disorders and levels of pro-inflammatory cytokines [25,26]. We obtained data on higher clinical efficiency in patients of the IA subgroup who received vitamin D in addition to background therapy, which was confirmed by an increase in the level of BA control compared to that in patients of the B (p = 0.01) and C (p = 0.037) subgroups.…”

Section: Groupmentioning

confidence: 99%

Effectiveness of Complex Treatment of Patients With Early-Onset and Late-Onset Bronchial Asthma Associated With Obesity

Kachkovska,

Kovchun,

Dudchenko

et al. 2024

EUMJ

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The objective of the study was a comparative assessment of the clinical effectiveness of atorvastatin and vitamin D effect on proteolytic activity in obese patients with BA depending on the age of BA onset. Materials and Methods. We examined 195 patients with BA and obesity and 95 apparently healthy individuals. The patients were divided into 2 groups with regard to the age of BA onset: Group I included 100 patients with early-onset asthma, and Group II included 95 patients with late-onset asthma. Patients with complete BA control at baseline and those having achieved BA control after background therapy adjustment were excluded from further study. Patients of Groups I (n = 65) and II (n = 68) were divided into subgroups A, B, and C: patients of IA (n = 23) and IIA (n = 22) subgroups received background treatment in combination with vitamin D; patients of IB (n = 20) and IIB (n = 25) subgroups – in addition to background treatment received atorvastatin; patients of IC (n = 22) and IIC (n = 21) subgroups received only background treatment. To measure TIMP-1, MMP-1, and MMP-9 levels, IBL International GMBH enzyme-linked immunosorbent assay kits (Hamburg, Germany) were used. Asthma control was assessed using ACQ-5 (Asthma Control Questionnaire-5). The study was approved by the Bioethics Committee of the Academic and Research Medical Institute of Sumy State University. The obtained results were statistically processed using the SPSS–17 program. The results of the study showed that MMP-1, MMP-9, and TIMP-1 levels in obese patients with late-onset BA were significantly higher vs. patients with early-onset BA. Background therapy and its combination with vitamin D or with atorvastatin contributed to a statistically significant decrease in the level of MMP-1, MMP-9, and TIMP-1 in patients of IA, IB, and IC subgroups. MMP-1 level decreased significantly in patients with late-onset BA in all subgroups, but it was significantly lower in patients of IIB subgroup vs. IIA subgroup (p = 0.001) and IIC subgroup (p = 0.001). MMP-9 level decreased significantly in patients of IIA and IIB subgroups, but it was significantly lower in patients of IIB subgroup vs. IIA subgroup (p = 0.001) and IIC subgroup (p = 0.001). This suggested that atorvastatin contributed to a more significant decrease in MMP‑9 level vs. background therapy and background therapy + vitamin D. TIMP-1 level decreased significantly only in patients of IIB subgroup and was lower vs. IIA subgroup (p = 0.001) and IIC subgroup (p = 0.001). We demonstrated higher clinical treatment efficiency in patients of the IA subgroup who received vitamin D in addition to background therapy, which was confirmed by an increase in the level of BA control compared to that in patients of the B (p = 0.01) and C (p = 0.037) subgroups. In patients with late-onset BA (IIB subgroup), atorvastatin contributed to a better BA control compared to patients of IIA and IIC subgroups. The maximum improvement of respiratory function in patients with early-onset BA was achieved with the combination of background therapy + vitamin D, while in patients with late-onset BA – with atorvastatin. Conclusions. The use of atorvastatin has a more significant impact on the level of remodeling markers, BA control, and respiratory function in obese patients with late-onset BA vs. early-onset BA. Better BA control and maximum improvement of respiratory function in obese patients with early-onset BA were achieved with the combination of background therapy + vitamin D.

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Section: Groupmentioning

confidence: 99%

Effectiveness of Complex Treatment of Patients With Early-Onset and Late-Onset Bronchial Asthma Associated With Obesity

Kachkovska,

Kovchun,

Dudchenko

et al. 2024

EUMJ

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hsa-mir-(4328, 4422, 548z and -628-5p) in diabetic retinopathy: diagnosis, prediction and linking a new therapeutic target

et al. 2023

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Effects of Long-Term Intervention with Losartan, Aspirin and Atorvastatin on Vascular Remodeling in Juvenile Spontaneously Hypertensive Rats

et al. 2023

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Hypertension in adolescents is associated with adverse cardiac and vascular events. In addition to lowering blood pressure, it is not clear whether pharmacological therapy in early life can improve vascular remodeling. This study aimed to evaluate the effects of long-term administration of losartan, aspirin, and atorvastatin on vascular remodeling in juvenile spontaneously hypertensive rats (SHRs). Losartan, aspirin, and atorvastatin were administered via gavage at doses of 20, 10, and 10 mg/kg/day, respectively, on SHRs aged 6–22 weeks. Paraffin sections of the blood vessels were stained with hematoxylin-eosin (H&E) and Sirius Red to evaluate the changes in the vascular structure and the accumulation of different types of collagen. The plasma levels of renin, angiotensin II (Ang II), aldosterone (ALD), endothelin-1 (ET-1), interleukin-6 (IL-6), and neutrophil elastase (NE) were determined using ELISA kits. After the 16-week treatment with losartan, aspirin, and atorvastatin, the wall thickness of the thoracic aorta and carotid artery decreased. The integrity of the elastic fibers in the tunica media was maintained in an orderly manner, and collagen deposition in the adventitia was retarded. The plasma levels of renin, ALD, ET-1, IL-6, and NE in the SHRs also decreased. These findings suggest that losartan, aspirin, and atorvastatin could improve vascular remodeling beyond their antihypertensive, anti-inflammatory, and lipid-lowering effects. Many aspects of the protection provided by pharmacological therapy are important for the prevention of cardiovascular diseases in adults and older adults.

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Atorvastatina Atenua o Remodelamento Vascular em Camundongos com Síndrome Metabólica

Cited by 4 publications

References 58 publications

Effectiveness of Complex Treatment of Patients With Early-Onset and Late-Onset Bronchial Asthma Associated With Obesity

Effectiveness of Complex Treatment of Patients With Early-Onset and Late-Onset Bronchial Asthma Associated With Obesity

hsa-mir-(4328, 4422, 548z and -628-5p) in diabetic retinopathy: diagnosis, prediction and linking a new therapeutic target

Effects of Long-Term Intervention with Losartan, Aspirin and Atorvastatin on Vascular Remodeling in Juvenile Spontaneously Hypertensive Rats

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